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Pussy and legs pics. Amazing ty fisting site. Beautiful oiled busty latina models. Asian girl with the perfect curves. Midget porn portal. Big tit female muscle freaks. Women dressed and nude. Watch Free Vittorio colao esposa disfunción sexual SEX Videos El teletrabajo ha sido históricamente una actividad casi residual en España. El estallido de la crisis vírica obligó a las empresas a mandar a sus empleados a trabajar desde casa, y a descubrir sobre la marcha las ventajas y defectos del trabajo a distancia. Pero han tenido que pasar tres meses para que la ministra de Trabajo, Yolanda Díaz, haya planteado la necesidad de regular esta actividad. Otros países europeos han actuado con mayor presteza ante la misma situación, y han establecido compensaciones para que el teletrabajo no suponga nunca un coste adicional para el empleado. Es el caso de Bélgica, que en marzo, tras obligar a teletrabajar, fijó un pago de click here euros mensuales -que desde el 1 de abril elevó hasta los ,48 euros- que permita a los empleados compensar los gastos adicionales de luz, calefacción o telecomunicaciones que se produzcan por el hecho de trabajar desde casa, señalan desde la consultora belga Group S. Desde el añoBélgica ya obligaba al empleador a compensar a los empleados que trabajaban a distancia con 20 euros mensuales por el uso de su propio ordenador, y 20 euros adicionales por Vittorio colao esposa disfunción sexual utilización profesional de una conexión a internet personal. Ayudas que ahora, y en determinados casos podrían llegar a sumarse a los ,48 euros mensuales fijados. Así, si lo hacen un día a la semana el pago Vittorio colao esposa disfunción sexual de 10 euros mensuales, si lo hacen dos días a la semana es de 20 euros mensuales En Suiza no hay una legislación que establezca una compensación para los trabajadores que realicen su función desde casa. Vittorio colao esposa disfunción sexual una reciente sentencia de un Tribunal Federal, recogida por RTS, ha obligado a una empresa a pagar a un trabajador al que obligó a teletrabajarfijando una indemnización de francos suizos unos euros al mes. Por su parte, Alemania lleva trabajando en el desarrollo de su normativa sobre el teletrabajo desde abril, como anunció su ministro Vittorio colao esposa disfunción sexual Trabajo, Hubertus Heil, que quiere que los trabajadores puedan seguir trabajando a distancia tras la pandemia. Apenas existe legislación sobre este asunto. Sin embargo, es sólo un preliminar marco jurídico, con muchos aspectos Vittorio colao esposa disfunción sexual deben ser precisados en una regulación posterior. Durante el estado de alarma, muchas compañías han dejado a sus trabajadores en sus casas. Aunque no tenían la obligación de proporcionarles material, algunas empresas si han asumido esos gastos, mientras en otras han tenido que afrontarlos los trabajadores. Watch Sex Videos Www.african girls fucking videos.

How boobs are formed. Between anda longitudinal epidemiological study was carried out on hunted ungulates in the French Hautes-Alpes department. In addition, mouflons Ovis gmelinii musimon were shown for the first time to be strongly infected These serological ELISA results were confirmed by comparative virus neutralization tests, performed on seven Pestivirus strains by using 15 seropositive samples. The highest antibody titers were directed against 2 BDV strains Av and 33s strainsrather than BDV-4, a strain responsible for Pyrenean-chamois epizooties.

However, no Pestivirus Vittorio colao esposa disfunción sexual was detected by reverse-transcriptase polymerase chain reaction in serum and spleen samples from seronegative animals and no virus was isolated from those samples either.

Efforts should be made to improve the protocol in order to be able to isolate and characterize the local strain. Finally, the oldness age and femaleness gender increase the risk of seroconversion in chamois. Pestiviruses infections at the Vittorio colao esposa disfunción sexual and domestic ruminants interface in the French Southern Alps. In alpine pasture, interspecies transmission has recently been incriminated in the epidemiology of pestivirus infection.

The aim of this study was to investigate pestivirus infections in wild and domestic ruminants sharing pastures in the French Southern Alps. Animal sera were screened for pestivirus antibodies against the pestivirus NS3 protein by a commercial blocking enzyme linked go here assay ELISA.

All 38 domestic herds tested were positive for pestivirus -specific antibodies. Individual sero-prevalence reached For wild ruminants, Thus, an active circulation of pestiviruses was demonstrated in both wild and domestic ungulates from the French Southern Alps. The results suggest that interspecies transmission between sheep and chamois probably occur. Pestivirus strains exist as quasispecies swarms of individual viruses in infected animals and the viral populations making up t Identification and epidemiology of a rare HoBi-like pestivirus strain in Bangladesh.

The genus pestivirus of the family flaviviridae consists of four recognized species: bovine viral diarrhoea virus 1 BVDV-1bovine viral diarrhoea virus 2 BVDV-2classical swine fever virus and border disease virus. Despite reports of serological evidence of BVDV in Bangladesh, the types of the virus circulating in cattle have not been identified.

We conducted surveillance in cattle from May to August in three government veterinary hospitals to characterize BVDV in cattle of Bangladesh.

The identification of this rare HoBi-like pestivirus or BVDV-3 strain in Bangladesh warrants further surveillance to evaluate its impact on livestock production. Seroprevalence Vittorio colao esposa disfunción sexual characterization of pestivirus infections in small ruminants and new world camelids in Switzerland. The seroprevalence of pestivirus infections in small ruminants and new world camelids in Switzerland was determined.

In 5' sera of sheep from herds, sera of goats from 54 herds and sera of alpacas and lamas from 53 herds, population prevalences of Based on the ratio of respective antibody titres, In goats, the corresponding proportions were In Alpacas and Lamas, the source of infection of 1 animal was BDV-1 and that of 4 seropositive animals remained unresolved.

In view of the phylogenetic relationship between pestivirusesthe unresolved source of infection is most probably attributable to other pestivirus genotypes circulating in small ruminants and new world camelids.

Due to the predominance of pestiviral genotypes other than BVDV-1, the risk of transmission of BVDV Vittorio colao esposa disfunción sexual persistently infected small ruminants and new world camelids to cattle appears to be moderate, apart from close direct contact in mixed animal husbandry, communal pasturing and grazing in the Alps.

Brefeldin A inhibits pestivirus release from infected cells, without affecting its assembly and infectivity. Vittorio colao esposa disfunción sexual considerable information has been gathered on virus entry into the host cell, genome structure and protein function, little is known about pestivirus morphogenesis and release from cells.

Here, we analyzed the intracellular Vittorio colao esposa disfunción sexual, N-glycan processing and secretion of BVDV using brefeldin Vittorio colao esposa disfunción sexual BFAwhich blocks protein export from the endoplasmic reticulum ER and causes disruption of the Golgi complex with subsequent fusion of its cis and medial cisternae with the ER.

BFA treatment of infected cells resulted in complete inhibition of BVDV secretion and increased article source of the envelope glycoproteins with the cis-Golgi marker GM Processing of the N-linked glycans was affected by BFA, however, virus assembly was not perturbed and intracellular virions were fully infectious, suggesting that trafficking beyond the cis-Golgi is not a prerequisite for pestivirus infectivity.

Identification of a novel virus in pigs--Bungowannah virus: a possible new species of pestivirus. In an outbreak of sudden deaths occurred in week-old piglets on a farm in New South Wales, Australia.

There was a marked increase in the birth of stillborn foetuses. Pathological changes consisted of a multifocal non-suppurative myocarditis.

A viral infection was suspected but a wide range of known agents were excluded. A modified sequence independent single primer amplification SISPA method was used to identify a novel virus associated with this outbreak. Conserved 5'UTR motifs, Vittorio colao esposa disfunción sexual presence of a putative N pro coding region and limited antigenic cross-reactivity with other members of the Pestivirus genus, support the placement of this web page virus in the Pestivirus genus.

Phylogenetic analysis of the 5'UTR, N pro and E2 coding regions showed this Vittorio colao esposa disfunción sexual to be the most divergent pestivirus identified to date.

Mucosal disease-like syndrome in a calf persistently infected by Hobi-like pestivirus. A calf persistently infected with Hobi-like pestivirus displayed severe clinical signs and subsequently died.

Gross lesions and histopathological changes were suggestive of hemorrhagic and necrotic inflammation involving Vittorio colao esposa disfunción sexual tissues. A Hobi-like pestivirus pair was isolated Vittorio colao esposa disfunción sexual the dead calf, i. Two biotype-specific real-time reverse transcription-PCR assays determined the time of the emergence of the CP virus as 1 month Vittorio colao esposa disfunción sexual the calf's death.

In contrast, great NCP virus loads were present in Vittorio colao esposa disfunción sexual tissues and biological fluids. The present report provides new insights into the pathogenesis and molecular mechanisms of this emerging group of pestiviruses. All Rights Reserved.

This web page and molecular characterisation of a pestivirus from goats in Egypt. Nine fetuses and neonates from sheep and goats in Egypt were screened for pestiviruses using immunohistochemistry IHCvirus isolation, and reverse transcription-polymerase chain reaction RT-PCR. Two goat kids with typical border disease BD were positive for pestivirus infection by immunohistochemistry IHC using polyclonal anti-BDV serum but not when four different monoclonal antibodies MAbs were used.

To our knowledge, this is the first report of isolation of a pestivirus from goats in Egypt and is probably the second report worldwide of a goat kid showing central nervous signs associated with border disease. Complementation studies with the novel "Bungowannah" virus Vittorio colao esposa disfunción sexual new insights in the compatibility of pestivirus proteins. In recent years several atypical pestiviruses have been described.

Bungowannah virus is the most divergent virus in this group. Therefore, heterologous complementation was used to clarify the phylogenetic relationship and to analyze the exchangeability of genome regions encoding structural proteins. While all constructs replicated autonomously, infectious high titer chimeric virus could only be observed after exchanging the complete E1-E2 encoding region.

The complementation of E1 and E2 alone resulted Vittorio colao esposa disfunción sexual in replicons. Our data provide new insights Vittorio colao esposa disfunción sexual the compatibility of pestivirus proteins and demonstrate that heterologous complementation could be useful to characterize new pestiviruses. Generation of recombinant pestiviruses using a full-genome amplification strategy. Read article, we have now used this full-genome amplification strategy for efficient and robust amplification of three additional pestivirus strains: the vaccine strain C and the virulent Paderborn strain of Classical swine fever virus plus the CP7 strain of Bovine viral diarrhoea virus.

The amplicons were cloned directly into a stable single-copy bacterial artificial chromosome generating full-length Vittorio colao esposa disfunción sexual DNAs from which infectious RNA transcripts could be also derived Genotypic characterization of Chilean llama Lama glama and alpaca Vicugna pacos pestivirus isolates. Llamas and alpacas are domesticated South American camelids Vittorio colao esposa disfunción sexual important to ancestral population in the Altiplano region, and to different communities worldwide where they have been introduced.

These ungulates have shown to be susceptible to several livestock viral pathogens such as members of the Pestivirus genus, in particular Bovine Viral Diarrhea BVDVbut there is little data available on Pestivirus infections in SACs. In this study we aimed to detect and identify Pestivirus genotypes and subgroups infecting SACs in both wild and confined environments.

Samples were collected from llamas and 30 alpacas from different areas in the Chilean Altiplano wild animalsand from 22 llamas and 26 alpacas diagnosed as Pestivirus positive from the Metropolitana region in Chile Vittorio colao esposa disfunción sexual animals. Seroneutralization tests showed titers lower than 2 in all Vittorio colao esposa disfunción sexual from Chilean Altiplano. These samples were also negative to BVDV isolation, indicating that these animals have not been exposed to Pestivirus.

Viral sequences were pairwise compared and phylogenetic trees were constructed. In agreement with these results, E2 phylogenetic analysis rendered a similar grouping indicating that all 16 isolates belong to BVDV However, the lower availability of E2 sequences determines the creation of a smaller number of sub-groups than the 5'NCR sequences.

Due to the universal availability of the 5'NCR segment, we propose the classification of these Chilean llamas and. Genetic diversity of pestivirus isolates in cattle from Vittorio colao esposa disfunción sexual Austria. The genetic diversity of bovine viral diarrhoea virus BVDV isolates in infected cattle from Tyrol and Vorarlberg Austria was investigated. Blood samples were collected within the compulsory Austrian BVDV control programme during and Correlation among isolates could only be observed at the farm level, i.

However, no correlation between the genetic and geographical distances could be observed above the farm level. Because of the wide distribution Vittorio colao esposa disfunción sexual certain BVDV-1 subtypes and the low prevalence of herd-specific strains, a determination of tracing routes of infection was not possible. Furthermore, recombination events were not detected. Efficacy of a novel antiviral compound to inhibit replication of multiple pestivirus species.

The pestiviruses are economically important pathogens of livestock. An aromatic cationic compound DB has previously been shown to inhibit Vittorio colao esposa disfunción sexual viral diarrhea virus BVDV Vittorio colao esposa disfunción sexual 1 in vitro at concentrations lacking cytotoxic side effects. The aim of this study was to determine the scope of anti Hobi emergent pestivirus : Its impact in animal health and importance as a contaminant in biotechnological products.

After the first detection from Brazilian samples in Germany inseveral Hobi-like isolates have been reported in Italy and some countries Vittorio colao esposa disfunción sexual Asia Congenital tremor type A-II in piglets has been regarded as a transmissible disease since the s, possibly caused by a very recently-described virus: atypical porcine pestivirus APPV.

Here, we describe several strains of APPV in piglets with clinical signs of congenital tremor 10 of 10 farms. Absence of circulation of Pestivirus between wild and domestic ruminants in southern Spain. Ruminant pestiviruses family Flaviviridae affect both wild and domestic ruminants worldwide, causing reproductive disorders and severe economic losses.

Results indicate that wild ruminants may act as spillover hosts from domestic ruminants, and therefore they do not represent a risk for domestic ruminants in southern Spain.

The wide distribution of pestiviruses among sheep and cattle suggests that transmission between these species may occur. British Veterinary Association. Knowledge on the morphogenesis of pestiviruses is limited due to low virus production in infected cells.

In order to localize virion morphogenesis and replication sites of pestiviruses and to examine intracellular virion transport, a cell culture model was established to facilitate ultrastructural studies. Based on results of virus growth kinetic analysis and quantification of viral RNA, pestivirus strain Giraffe-1 turned out to be a suitable candidate for studies on virion generation and export from culture cells.

Using conventional transmission electron microscopy and single-tilt electron tomography, we found virions located predominately in the lumen of the endoplasmic reticulum ER in infected cells and were able to depict the budding process of virions at ER membranes. Colocalization of the viral core protein and the envelope glycoprotein E2 with the ER marker protein disulfide isomerase PDI was demonstrated by immunogold labeling of cryosections.

Moreover, pestivirions could be shown in transport vesicles and the Golgi complex and during exocytosis. Interestingly, viral capsid protein and double-stranded RNA dsRNA were detected in multivesicular bodies MVBswhich implies that the endosomal compartment plays a role in pestiviral replication.

Significant cellular membrane alterations such as those described for members of the Flavivirus and Hepacivirus genera were not found. Based on the gained morphological data, we present a consistent model of pestivirus morphogenesis.

Towards a Vittorio colao esposa disfunción sexual suspension array for the detection of pestivirus antibodies in swine. Classical swine fever CSF is a highly contagious and lethal disease in swine. Serological tests for the diagnosis of CSF need not only to detect antibodies against CSFV, but also need to differentiate these from antibodies against other pestiviruses.

To investigate Vittorio colao esposa disfunción sexual possibilities of specific peptide-based serology, various synthetic peptides that represent a well-described linear epitope of the CSFV E2 protein TAVSPTTLR were used to test the viability of a peptide-based suspension array for the detection of antibodies against pestiviruses in swine. The results show that N-terminally biotinylated peptides can bind to avidin conjugated beads, and function in detection of the corresponding monoclonal antibody WH There are indications that the length of the spacer between epitope and biotin affect the efficiency of the peptide-antibody interaction.

A protocol was established that enables probing for antibodies in porcine sera, where neutravidin-blocking of serum and the use of empty control beads for normalization was crucial. With a set of porcine sera with antibodies against various pestivirusesthe proof of concept of a peptide-based suspension array for specific detection of antibodies against pestiviruses in porcine sera was demonstrated. Pestivirus and alphaherpesvirus infections in Swedish reindeer Rangifer tarandus tarandus L.

Herding semi-domesticated reindeer has economic and social value for Sami people in the northern territories of Fennoscandia. However, with the intensification of reindeer husbandry, interspecies transmission of source between reindeer and domestic animals may become go here problem, especially for countries such as Sweden, Norway, and Finland where pestivirus and alphaherpesvirus have been eradicated in domestic ruminants.

While the seroprevalence of alphaherpesvirus was similar in different herding districts, pestivirus seropositivity was highest in the South and diminished towards the North of the Swedish reindeer herding area. High correlation of the seropositivity against both pathogens at both individual and herd levels may indicate possible mutual synergetic effects and may be explained by the immunosuppressive nature of the viruses.

While alphaherpesvirus seroprevalence was probably related to putative cervid herpesvirus 2 CvHV-2the pestivirus infecting reindeer remains undefined.

The study showed that pestivirus and alphaherpesvirus infections are endemic in the Swedish reindeer population. Comparison of the performance of five different immunoassays to detect Vittorio colao esposa disfunción sexual antibodies against emerging atypical bovine pestivirus. Bovine pestiviruses represent Vittorio colao esposa disfunción sexual considerably variable group. In addition to the two accepted species Vittorio colao esposa disfunción sexual and BVDV-2, a number of atypical bovine pestiviruses have been detected both in foetal calf sera and in field samples.

The sera collected during the initial six weeks of experimental As expected, virus neutralization tests using homologous virus were able to differentiate the two groups infected It was found that immunoassays using whole virus and polyclonal antibodies are the most robust, but all tests examined were able to detect Molecular identification of a new pestivirus associated with increased mortality in the Pyrenean Chamois Rupicapra pyrenaica pyrenaica in Spain.

Pestivirus infection was identified in 16 of 17 chamois during an outbreak of a previously unreported disease in Pyrenean chamois Rupicapra pyrenaica pyrenaica in northeastern Spain in By analysis of the 5' noncoding regions of the virus, we assigned it to the border disease virus cluster with pairwise similarity values ranging from It will be important to investigate the association of this pestivirus with disease in Pyrenean chamois.

Seroprevalence of pestivirus in four species of alpine wild ungulates in the High Valley of Susa, Italy. Wildlife, once infected, can serve as a reservoir of infectious diseases that form a constant threat to domestic livestock. To make control and eradication programs successful in the long-term, presence of pestivirus in wildlife populations should be monitored. The goal of this study was to investigate seroprevalence of pestivirus in four alpine wild ungulates in the High Valley of Susa, north-west Italy.

Species studied were: red deer Cervus elaphusroe Vittorio colao esposa disfunción sexual Capreolus capreoluswild boar Sus scrofa and chamois Rupicapra rupicapra. A further goal was using virus neutralisation tests VNT Vittorio colao esposa disfunción sexual four strains of pestivirus in chamois and wild boar. Three hundred and seventy-five serum samples collected during the hunting season of were tested for pestivirus specific antibodies.

Positive sera of chamois and wild boar were subsequently tested in a VNT with four major subtypes of pestivirusand virus isolation was performed. No antibodies were found in the 73 samples of roe deer, while 7 Several possibilities, which might explain the high seroprevalence in chamois are discussed.

Pestivirus antibodies were found in three out of four large alpine ungulates in the High Valley of Susa. Seroprevalence was particularly high in chamois. Further investigation is needed to characterise the pestiviruses that circulate in these animals. A multiplex RT-PCR assay for the rapid and differential diagnosis of Vittorio colao esposa disfunción sexual swine fever and other pestivirus infections. Classical swine fever is a highly contagious viral disease causing severe economic losses in pig production almost worldwide.

All pestivirus species can infect pigs, therefore accurate and rapid pestivirus detection and differentiation is of great importance to assure control measures in swine farming. Here we describe the development and evaluation of a novel multiplex, highly sensitive and specific RT-PCR for the simultaneous detection and rapid differentiation between CSFV and other pestivirus infections in swine. The universal and differential detection was based on primers designed to amplify a fragment of the 5' non-coding genome region for the detection of pestiviruses and a fragment of the NS5B gene for the detection of classical swine fever virus.

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Palawan sex Watch Porn Movies Cuckold cumshot. Desde el año , Bélgica ya obligaba al empleador a compensar a los empleados que trabajaban a distancia con 20 euros mensuales por el uso de su propio ordenador, y 20 euros adicionales por la utilización profesional de una conexión a internet personal. Ayudas que ahora, y en determinados casos podrían llegar a sumarse a los ,48 euros mensuales fijados. Así, si lo hacen un día a la semana el pago es de 10 euros mensuales, si lo hacen dos días a la semana es de 20 euros mensuales En Suiza no hay una legislación que establezca una compensación para los trabajadores que realicen su función desde casa. Pero una reciente sentencia de un Tribunal Federal, recogida por RTS, ha obligado a una empresa a pagar a un trabajador al que obligó a teletrabajar , fijando una indemnización de francos suizos unos euros al mes. Por su parte, Alemania lleva trabajando en el desarrollo de su normativa sobre el teletrabajo desde abril, como anunció su ministro de Trabajo, Hubertus Heil, que quiere que los trabajadores puedan seguir trabajando a distancia tras la pandemia. The ability of rE2 glycoprotein to inhibit the infection of permissive cells by both homologous and heterologous virus was compared, revealing that the inhibitory effects of rE2 glycoproteins correlated with the predicted similarity of the E2 structures in the recombinant protein and the test virus. This result suggests that the sequence and structure of E2 are likely to be involved in the host specificity of pestiviruses at their point of uptake into cells. Genomic and antigenic relationships between two 'HoBi'-like strains and other members of the Pestivirus genus. To date, few complete genome sequences of 'HoBi'-like viruses are available in public databases. Moreover, detailed analyses of such genomes are still scarce. In an attempt to expand data on the genetic diversity and biology of pestiviruses , two genomes of 'HoBi'-like viruses recovered from Brazilian cattle were described and characterized in this study. Analysis of the whole genome and antigenic properties of these two new 'HoBi'-like isolates suggest that these viruses are genetically close to recognized pestiviruses. The present data provide evidence that 'HoBi'-like viruses are members of the genus Pestivirus and should be formally recognized as a novel species. The viral envelope is not sufficient to transfer the unique broad cell tropism of Bungowannah virus to a related pestivirus. Bungowannah virus is the most divergent pestivirus , and both origin and reservoir host have not been identified so far. We therefore performed in vitro tropism studies, which showed that Bungowannah virus differs remarkably from other pestiviruses. Interestingly, cell lines of vervet monkey, mouse, human and even of bat origin were susceptible. This broad in vitro tropism was not observed for a chimeric bovine viral diarrhoea virus BVDV expressing all structural proteins of Bungowannah virus. The viral envelope was not sufficient to completely transfer the cell tropism of Bungowannah virus to another pestivirus , and viral RNA replication was either markedly reduced or not detectable in a number of different cell lines for the tested BVDV strain and the chimera. We therefore suggest that the replication machinery together with the viral envelope is responsible for the unique broad cell tropism of Bungowannah virus. Numerical taxonomy of the genus Pestivirus : new software for genotyping based on the palindromic nucleotide substitutions method. Pestivirus identification using PNS was evaluated on five hundred and forty-three sequences at genus, species and genotype level using this software. The software is freely available at www. A serosurvey for ruminant pestivirus exposure conducted using cattle sera collected for brucellosis surveillance in the United States. Four species of ruminant pestivirus are currently circulating in the United States: Bovine viral diarrhea virus 1 and 2 BVDV-1, -2; predominant host: cattle , Border disease virus BDV; predominant host: sheep , and pronghorn virus sporadically detected in wild ruminants. A third bovine pestivirus called HoBi-like virus has been detected in cattle and water buffalo in South America, Asia, and Europe. To date, no isolations of HoBi-like viruses from U. To assess exposure, 2, cattle sera, collected between and as part of the U. In addition, RNA was extracted and tested by reverse transcription-polymerase chain reaction for the presence of pestiviruses ; all samples tested negative. The percent of VN-positive samples was Because the 3 bovine pestiviruses are antigenically cross-reactive, the comparative level of antibody against each pestivirus species was determined. Based on comparative titers, samples were segregated into 6 categories: no titers 7. X-ray structure of the pestivirus NS3 helicase and its conformation in solution. Pestiviruses form a genus in the Flaviviridae family of small enveloped viruses with a positive-sense single-stranded RNA genome. Viral replication in this family requires the activity of a superfamily 2 RNA helicase contained in the C-terminal domain of nonstructural protein 3 NS3. The structure deviates significantly from that of NS3 of other genera in the Flaviviridae family in D3, as it contains two important insertions that result in a narrower nucleic acid binding groove. We also show that mutations in pNS3h that rescue viruses from which the core protein is deleted map to D3, suggesting that this domain may be involved in interactions that facilitate particle assembly. Finally, structural comparisons of the enzyme in different crystalline environments, together with the findings of small-angle X-ray-scattering studies in solution, show that D2 is mobile with respect to the rest of the enzyme, oscillating between closed and open conformations. Binding of a nonhydrolyzable ATP analog locks pNS3h in a conformation that is more compact than the closest apo-form in our crystals. Together, our results provide new insight and bring up new questions about pNS3h function during pestivirus replication. Although pestivirus infections impose an important toll on the livestock industry worldwide, little information is available about the nonstructural proteins essential for viral replication, such as the NS3 helicase. We provide here a comparative structural and functional analysis of pNS3h with respect to its orthologs in other viruses of the same family, the flaviviruses and hepatitis C virus. Our studies reveal differences in the nucleic acid binding groove that could have implications for understanding the. In this study, we report the first complete nucleotide sequence of BDV, that of strain X The genome is 12, nucleotides long and contains one long open reading frame encoding 3, amino acids. Comparison of the deduced amino acid sequence of X with the ones of other pestiviruses allowed the prediction of polyprotein cleavage sites which were conserved with regard to the structural proteins. Tautz, K. Elbers, D. Stoll, G. Meyers, and H. Thiel, J. Xu, E. Mendez, P. Caron, C. Lin, M. Murcko, M. Collett, and C. Rice, J. Evaluation of envelope glycoprotein E rns of an atypical bovine pestivirus as antigen in a microsphere immunoassay for the detection of antibodies against bovine viral diarrhea virus 1 and atypical bovine pestivirus. Atypical bovine pestiviruses are related antigenically and phylogenetically to bovine viral diarrhea viruses BVDV-1 and BVDV-2 , and may cause the same clinical manifestations in animals. The recombinant E rns protein was used as an antigen in a microsphere immunoassay for the detection of antibodies against BVDV-1 and atypical bovine pestivirus. The diagnostic performance of the new method was evaluated by testing a total of serum samples, and the assay was compared with enzyme-linked immunosorbent assay ELISA. The immunoassay was able to detect antibodies against both BVDV-1 and the atypical pestivirus. This novel microsphere immunoassay has the potential to be multiplexed for simultaneous detection of antibodies against different bovine pathogens in a high-throughput and economical way. Temporal dynamics of 'HoBi'-like pestivirus quasispecies in persistently infected calves generated under experimental conditions. Pestivirus strains exist as quasispecies swarms of individual viruses in infected animals and the viral populations making up the quasispecies differ widely in size and diversity in each animal. In the present study the viral quasispecies circulating in persistently infected PI calves, generated and maintained under experimental conditions using two different 'HoBi'-like strains, was observed over time. An increase in genetic variability and the development of certain mutations was observed over time. It is hypothesized that these changes may be the results on continued adaption of the pestivirus to individual hosts. This is the first study characterizing variation in the viral swarms of animals persistently infected with HoBi-like viruses over time. Studies of the shifts in PI viral swarms will contribute to our understanding of the host and viral mechanisms that function in the maintenance of pestivirus persistent infections. Circulating immune cell subpopulations in pestivirus persistently infected calves and non-infected calves varying in immune status. Circulating immune cell subpopulations in cattle representing varying stages of immune status categorized as; colostrum deprived CD , receiving colostrum COL , colostrum plus vaccination VAC and persistently infected with a pestivirus PI were compared. The PI calves were infected with a HoBi Challenges in identifying and determining the impacts of infection with pestiviruses on the herd health of free ranging cervid populations. Although most commonly associated with the infection of domestic livestock, the replication of pestiviruses , in particular bovine viral diarrhea virus BVDV , occurs in a wide range of free ranging cervids including white-tailed deer, mule deer, fallow deer, elk, red deer, roe deer, eland and moused Circulating immune cell subpopulations in pestivirus persistently infected calves and non-infected calves varying in immune status [Abstract. The circulating immune cell subpopulations in cattle representing varying stages of immune status categorized as; colostrum deprived CD , receiving colostrum COL , colostrum plus vaccination VAC and persistently infected with a pestivirus PI were compared. The PI calves were infected with a H Four species of ruminant pestivirus are currently circulating in the United States U. A third bovin Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses. The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys in E2 as the site of disulfide bond linkage with E1 to form E1—E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain. Autocatalytic activity and substrate specificity of the pestivirus N-terminal protease Npro. Pestivirus N pro is the first protein translated in the viral polypeptide, and cleaves itself off co-translationally generating the N-terminus of the core protein. Once released, N pro blocks the host's interferon response by inducing degradation of interferon regulatory factor N pro' s intracellular autocatalytic activity and lack of trans-activity have hampered in vitro cleavage studies to establish its substrate specificity and the roles of individual residues. We constructed N pro -GFP fusion proteins that carry the authentic cleavage site and determined the autoproteolytic activities of N pro proteins containing substitutions at the predicted catalytic sites Glu22 and Cys69, at Arg that forms a salt bridge with Glu22, and at the cleavage site Cys Contrary to previous reports, we show that N pro' s catalytic activity does not involve Glu22, which may instead be involved in protein stability. Furthermore, N pro does not have specificity for Cys at the cleavage site even though this residue is conserved throughout the pestivirus genus. Transmission of a pestivirus infection in a population of Pyrenean chamois. Outbreaks of a previously unrecorded disease have recently affected Pyrenean chamois Rupicapra pyrenaica pyrenaica populations across the mountain range. A pestivirus was hypothesized to be the cause of this emerging disease and this type of virus can cross the species barrier and be transmitted to or from wildlife. Using an epidemiological survey conducted from to at Orlu, France, we characterized the virus and analyzed its transmission. A phylogenetic analysis of viral sequences and virus neutralization tests showed that the virus belonged to the newly described border disease virus-4 group. The increase of seroprevalence with age indicated that infection can occur at any age and resulted in lifelong immunity. Overall, Infection has thus been widespread in this population since , whereas no mass mortality or clinical signs have been observed. Incidence and seroprevalence varied seasonally and according to number of individuals aged less than 2 years old in the population, so viral transmission was dependent on host population age structure. We propose that the virus is now endemic in this population and is likely detrimental for reproduction and juveniles. Further investigation is needed to estimate the impact of pestivirus on host population dynamics and the risk of cross-transmission to farm animals. A survey of antibodies to pestivirus in sheep in the Republic of Ireland. Full Text Available Sera from 1, adult ewes in 91 flocks, representing all 26 counties in the Republic of Ireland, were examined for pestivirus antibodies using a commercially available ELISA which detected IgG1 antibody to border disease virus. Eighty-one sheep 5. Within infected flocks, the mean seroprevalence level was The highest antibody prevalence was detected in sheep from central lowland counties of Ireland. Although there are high numbers of infected flocks, many sheep within such flocks remain antibody-negative and are at risk of giving birth to lambs with congenital border disease. Congenital infection with atypical porcine pestivirus APPV is associated with disease and viral persistence. In , several Austrian piglet-producing farms recorded outbreaks of action-related repetitive myoclonia in newborn piglets "shaking piglets". Malnutrition was seen in numerous piglets as a complication of this tremor syndrome. Histological examination of the CNS of affected piglets revealed moderate hypomyelination of the white substance in cerebellum and spinal cord. In confirmation with previous reports, APPV genomes were identified in different body fluids and tissues including the CNS of diseased piglets. APPV could be isolated from a "shaking piglet", which was incapable of consuming colostrum, and passaged on different porcine cells at very low titers. APPV genomes were detected continuously in piglets that gradually recovered from CT, while the antibody titers decreased over a week interval, pointing towards maternally transmitted antibodies. High viral loads were detectable by qRT-PCR in saliva and semen of infected young adults indicating a persistent infection. Serum neutralization as a differential serological test for classical swine fever virus and other pestivirus infections. Ninety-nine sera out of a sample of 16, were positive for antibodies to pestiviruses in an ELISA test which did not distinguish antibodies to different pestiviruses. In most of these sera 13 out of 17 the differences between SN titres against the three viruses were not sufficient to estimate which was the most likely antibody-inducing virus. It was concluded that, for the SN to be useful in such differentiation, it is essential to examine a sample which must include a representative number of sera from the same farm where suspect animals were detected. When isolated serum samples are examined, such as those obtained with the sampling strategy adopted here, the SN may give rise to inconclusive results. Gaeta N. Departamento de Clínica Médica. E-mail: natalia. There were no associations between any reagent animals and the risk factors studied. This work is one of the pioneers in the study of the prevalence of anti- pestivirus antibodies in Brazilian sheep flocks. The low frequency and low viral titer observed suggest that pestivirus are not an important agent related to the presence of reproductive disorders in sheep herds. Comparison of the cross-antibody response induced in sheep by inactivated bovine viral diarrhoea virus 1 and Hobi-like pestivirus. Hobi-like pestivirus , a new tentative species within genus Pestivirus , was firstly detected in foetal bovine serum batches and later associated to respiratory distress and reproductive failures in cattle. In the present study, the cross-antibody response between bovine viral diarrhoea virus 1 BVDV-1 and the emerging pestivirus was evaluated in the sheep model. Ten sheep were immunised against BVDV-1 or Hobi-like pestivirus using inactivated preparations and the induced antibody responses were evaluated against the homologous and heterologous viruses. The results showed that heterologous antibody titres were significantly lower than the homologous ones, thus suggesting the need to develop specific vaccines against the emerging pestiviral species. Circulation of multiple subtypes of bovine viral diarrhoea virus type 1 with no evidence for HoBi-like pestivirus in cattle herds of southern Italy. In the present paper, the results of an epidemiological survey for pestiviruses circulating in cattle in southern Italy are presented. BVDV-1 displayed a high level of genetic heterogeneity, which can have both prophylactic and diagnostic implications. In addition, the detection of BVDV-2c highlights the need for a continuous surveillance for the emergence of new pestivirus strains in cattle farms in southern Italy. HoBi-like pestiviruses are emerging pestiviruses that infect cattle causing clinical forms overlapping to those induced by bovine viral diarrhea virus BVDV 1 and 2. As a consequence of their widespread distribution reported in recent years, molecular tools for rapid discrimination among pestiviruses infecting cattle are needed. The aim of the present study was to develop a multiplex real-time RT-PCR assay, based on the TaqMan technology, for the rapid and unambiguous characterisation of all bovine pestiviruses , including the emerging HoBi-like strains. The assay was found to be sensitive, specific and repeatable, ensuring detection of as few as 10 0 1 viral RNA copies. No cross-reactions between different pestiviral species were observed even in samples artificially contaminated with more than one pestivirus. Peptides deduced from the C-terminal end residues to of pestivirus envelope protein Erns were used to develop enzyme-linked immunosorbent assays ELISAs to measure specifically antibodies against different types of pestiviruses. The choice of the peptide was based on the modular structure of the Erns protein, and the peptide was selected for its probable independent folding and good exposure, which would make it a good candidate for an antigenic peptide to be used in a diagnostic test. A solid-phase peptide ELISA which was cross-reactive for several types of pestivirus antibodies and which can be used for the general detection of pestivirus antibodies was developed. To identify type-specific pestivirus antibodies, a liquid-phase peptide ELISA, with a labeled, specific classical swine fever virus CSFV peptide and an unlabeled bovine viral diarrhea virus peptide to block cross-reactivity, was developed. Because the peptide is a fragment of the Erns protein, it can be used to differentiate between infected and vaccinated animals when a vaccine based on the E2 protein, which is another pestivirus envelope protein, is used. A group of emerging bovine pestiviruses becomes a possible threat to Bovine Viral diarrhea virus BVDV control and eradication programs in the countries of their origin and in the new continents due to the lack of validated detection methods. Analysis of a panel of sera obtained from calves experimentally inoculated with Hobi-like virus isolated from a calf from Thailand and BVDV type 1 strain using five different ELISA kits in comparison to neutralization test was performed. The specificity and sensitivity of the tests depended greatly Miscellanea, casistica personale, aspetti clinici e con Tomografia Computerizzata. Moreover, Helical CT could provide the early diagnosis of active bleeding in the peritoneum and of focal bleeding in the liver, thus permitting prompt hepatorrraphy or targeted hepatectomy. A diaphragm injury suspected at CT should always prompt the surgeon to intervention, especially when hemothorax, lung base pneumothorax, large liver hematoma or tear of the liver dome are associated. Finally, subdiaphragmatic free gas indicates gut perforation associated with liver damage, in which case surgery is necessary too. Scopo del lavoro e' di illustrare i vari quadri clinico-radiologici della nostra casistica personale, determinati da lesioni penetranti da armi da fuoco e da punta e taglio. Definire inoltre la modalita' di diagnosi, soprattutto in base ai segni TC del danno epatico e di lesioni associate, che condizionano in modo decisivo la terapia e l'approccio chirurgico o conservativo. Negli ultimi sette anni sono stati studiati retrospettivamente 31 casi 19 maschi e 12 femmine; eta' media 42 anni, compresa tra 18 e 73 anni , con lesioni penetranti del fegato, dovute prevalentemente a armi da fuoco 16 pazienti , a armi da punta e taglio 9 casi e miscellanee in 6. L'esame TC dell'addome e' stato eseguito in emergenza e con tecnica angio-TC in tutti i pazienti. Nei casi di ferite con sospetto coinvolgimento toraco-addominale, la TC veniva iniziata dal medio-torace al fine di una valutazione accurata del diaframma, delle basi polmonari e per escludere lesioni pleuropolmonari associate. Fra tradizione e sperimentazione: tecniche narrative nei racconti di Fra tradizione e sperimentazione: tecniche narrative nei racconti di Paola Capriolo. R Wilson, V Gerrand. Contemporary novelists have responded in different ways to the challenge of living and writing in the latter half of the twentieth century, a historical moment in which the paper and ink with which they have Neurofibromatosis 1 NF1 is an autosomal dominant condition characterized by neuro-cutaneous involvement and a predisposition to tumour development. Resting-state fMRI has recently emerged as a powerful tool for functional brain analysis, allowing the examination Valutazione dello spostamento tridimensionale degli impianti in giovani pazienti affetti da EDs riabilitati con overdenture implanto-supportati. Ectodermal Dysplasias syndrome EDs are a heterogeneous group of inherited disorders characterized by dysplasia of tissues of ectodermal origin. Complete or partial anodontia are the most frequent dental findings. Prosthetic rehabilitation is recommended from functional, esthetic, and psychological points of view. Because of the anatomical abnormalities of existing teeth and alveolar ridges, conventional prosthetic rehabilitation in young patient is often difficult. Five growing patients ag Il diritto alla salute dei migranti nei Paesi Bassi. The increased prevalence of drug resistant strains of Mycobacterium tuberculosis Mtb indicates that significant mutagenesis occurs during tuberculosis disease in humans. In this study we assess the contribution of Nei and Nth DNA repair enzymes in Mycobacterium smegmatis Msm , which retains a single nth homologue and duplications of the Fpg fpg1 and fpg2 and Nei nei 1 and nei 2 homologues. Using an Escherichia coli nth deletion mutant, we confirm the functionality of the mycobacterial nth gene in the base excision repair pathway. Msm mutants lacking nei 1, nei 2 and nth individually or in combination did not display aberrant growth in broth culture. Deletion of nth individually results in increased UV-induced mutagenesis and combinatorial deletion with the nei homologues results in reduced survival under oxidative stress conditions and an increase in spontaneous mutagenesis to rifampicin. Furthermore, no differential emergence of the common rifampicin resistance conferring genotypes were noted. Collectively, these data confirm a role for Nth in base excision repair in mycobacteria and further highlight a novel interplay between the Nth and Nei homologues in spontaneous mutagenesis. All rights reserved. Le norme statali in materia di tutela penale dei culti e del sentimento religioso. Alcune sommarie considerazioni. Chiacchierare con le immagini, l'uso delle fotografie nei servizi di microblogging. Images and visual content in general constitute a large part of online communication. This chapter attempts a first analysis of the role played by images within a microblogging platform suggesting three categories: self-portraits, user generated content, and screenshots The map service was created for inclusion Parlare con le immagini. Come i media possono ridare voce a persone affette da afasia. Neuropeptide glutamic acid-isoleucine NEI -induced paradoxical sleep in rats. Neuropeptideglutamic acid-isoleucine NEI as well as melanin concentrating hormone MCH is cleaved from the amino acid protein, prepro-melanin concentrating hormone prepro-MCH. However, there are no studies on the effect of NEI on the sleep-wake cycle. Icv injection of NEI 0. Sezary syndrome SS is a rare primay epidermotropic cutaneous T-cell lymphoma in leukemic. The aetiopathogenesis of MF and SS remains obscure despite several investigations. Infectious, environmental and genetic factors have been implicated as potential aetiological agents. The different sensitivities of the technical methods used in the evaluation of the presence of viral DNA or virus-related antigens make comparison of the results difficult. Skin biopsies were obtained from 21 MF and 10 SS patients; skin biopsies from a 8 patients with inflammatory skin disease were used as controls. EBV-negative patients even if not statistically significant. We are going to investigate the presence of EBV-DNA in peripheral blood of a larger number of patients and to evaluate the pattern of viral genes expression, to better assess the aetiopathogenetical role of EB virus in this kind of neoplasies. Analisi delle antibiotico-resistenze di Gram-negativi isolati da pazienti con infezioni del tratto urinario afferenti al Polo Oncologico e Dermatologico I. Urinary tract infections represent a worlwide problem due to their prevalence among nosocomial infections and to the increasing frequency of antibiotic resistance among the Gram-negative pathogens. Knowledge of the antimicrobial resistance patterns according to local epidemiology is essential for providing clinically appropriate therapy for urinary tract infection. In the present study we analysed the drug resistence pattern of Gram negative bacteria isolated from urine samples Full Text Available Introduction. In the present study we analysed the drug resistence pattern of Gram negative bacteria isolated from urine samples of patients with urinary tract infections at the Microbiological Laboratory of I. Materials and Methods. A total isolates have been collected during three years Isolates were subcultured to Agar blood-Mac-Conckey and analysed in the Vitek 1 for identification and drug susceptibility. Proteus mirabilis, Klebsiella pneumoniae, and Pseudomonas aeruginosa, were less frequently isolated 9. The E. The P. The increased drug resistance developed by bacteria consistently due to previous treatments with several antimicrobial drugs makes it essential the culture and susceptibility testing in genitourinary tract infection before instituting antimicrobial therapy. Empirical antimicrobial therapy should be avoided or reassessed by 48 to 72 hours after initation based on preterapy culture results. Metodi : in uno studio retrospettivo sono stati analizzati campioni di siero provenienti da 34 soggetti 27M, 7F; età media Mutazioni nel gene S sembrano correlare con il genotipo D e la tossicodipendenza. The baseline methodology of NEI is composed of break selection, debris generation, latent debris, debris transport, and head loss. In Korea nuclear industry also keeps step with international activities of this safety issue, with Kori 1 plant as a pioneering edge. Korean nuclear industry has been also pursuing development of an advanced PWR of APR, which incorporates several improved safety features. This device, as the acronym implies, changes the emergency core cooling water injection pattern. This fact makes us to review the applicability of NEI 's methodology. In this paper we discuss the applicability of NEI 07's methodology, and more over, new methodology is proposed. And finally the preliminary debris transport is analyzed. Trauma e vulnerabilità nei migranti richiedenti protezione internazionale. From this classic traditional source may be derived the concept of a balanced and complete diet and probably the world's first dietary guidelines. Basic to the tradition are han, re, wen and bu foods, respectively 'cold', 'hot', 'neutral', 'strengthening'. Basic to Chinese cuisine are jan and tsai- 'cereal' the rice staple and main meal and 'dishes' to accompany the rice. Chinese traditional medicine, as in Huang Di Nei Jing, considers the nourishment of body and mind. It also emphasises that herbal medicine and food have the same origin. Diet was essential to the prevention of disease which a glossary of Chinese terms is given at the end of the paper in the Chinese tradition, was superior to treatment. Treatment of TB requires long-term courses of multi-drug therapies to eliminate subpopulations of bacteria, which sometimes persist against antibiotics. Therefore, understanding of the mechanism of Mtb antibiotic-resistance is extremely important. During infection, Mtb overcomes a variety of body defense mechanisms, including treatment with the reactive species of oxygen and nitrogen. The bases in DNA molecule are susceptible to the damages caused by reactive forms of intermediate compounds of oxygen and nitrogen. Most of this damage is repaired by the base excision repair BER pathway. Methods: XthA, nfo, and nei genes were identified in mycobacteria by homology search of genomic sequences available in the GenBank database. The protein products of Mtb genes were expressed and purified in Escherichia coli using affinity tags. The enzymatic activity of purified Nfo, XthA, and Nei 2 proteins were measured using radioactively labeled DNA substrates containing various modified residues. The plasmid constructs were verified by sequencing and then transformed into the Escherichia coli BL21 DE3 strain. Identification of the isolated proteins was performed by. The aim of this study was to evaluate different approaches to scoring the National Eye Institute Visual Functioning Questionnaire NEI VFQ in patients with low vision including scoring by the standard method, by Rasch analysis, and by use of an algorithm created by Massof to approximate Rasch person measure. Subscale validity and use of a 7-item short form instrument proposed by Ryan et al. NEI VFQ data from 50 patients with low vision were analyzed using the standard method of summing Likert-type scores and calculating an overall average, Rasch analysis using Winsteps software, and the Massof algorithm in Excel. Correlations between scores were calculated. Rasch person separation reliability and other indicators were calculated to determine the validity of the subscales and of the 7-item instrument. Scores calculated using all three methods were highly correlated, but evidence of floor and ceiling effects was found with the standard scoring method. None of the subscales investigated proved valid. The 7-item instrument showed acceptable person separation reliability and good targeting and item performance. Although standard scores and Rasch scores are highly correlated, Rasch analysis has the advantages of eliminating floor and ceiling effects and producing interval-scaled data. The Massof algorithm for approximation of the Rasch person measure performed well in this group of low-vision patients. The validity of the subscales VFQ should be reconsidered. Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle. We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine-amide NEI concentrations in discrete brain areas in male rats. To investigate the possible effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone LH , estradiol and progesterone concentrations were measured in control, hypothyroid hypoT, treated with PTU during days and hyperthyroid hyperT, l-T4 during days animals. Both treatments blunted the LH surge. Hypo- and hyperthyroidism increased estradiol concentrations during proestrus afternoon P-PM , although hypoT rats showed lower values compared to control during proestrus morning P-AM. NEI concentrations were lower in hypoT rats during the estrous cycle except in estrus E in the peduncular part of the lateral hypothalamus PLH. The present results indicate that NEI concentration is regulated in a complex manner by hypo- and hyperthyroidism in the different areas studied, suggesting a correlation between NEI values and the variations of gonadal steroid levels during estrous cycle. These changes could be, in part, responsible for the alterations observed in the hypothalamic-pituitary-gonadal axis in these pathologies. Prostatic biopsy in the prostate specific antigen gray zone; La biopsia prostatica multipla nalla zona grigia dei valori dell'antigene prostatico specifico. Drudi, F. La Sapienza, Rome Italy. Of the patients who gave full informed consent, 34 people were selected whose age range was between 56 to 76 years mean: PSA velocity was calculated collecting 3 blood samples every 30 days for 2 months. Our findings confirm that prostatic biopsy can detect tumors also in areas which appear normal at transrectal US and digital examination, and that PSA rate increases in patients with positive histology. Finally, the actual clinical role of prostatic biopsy relative to all other diagnostic imaging techniques remains to be defined. Di questi sono stati selezionati eta' tra 56 e 76 anni, eta' media 64 anni. Energy and telecommunications public services; Servizi pubblici nei settori dell'energia e delle telecomunicazioni. Salini, M. The aim of this work is the evolution of the energy and telecommunication public services. The article runs through the main stages in the public services' history and shows how open market rules may cause the future dissolution of public service notion. The conclusion wishes the hastening of public services privatisation and a Corporate Governance reform as a mean to pursue general interest. Se ne ripercorrono le principali tappe storiche e si evidenzia come le regole di apertura dei mercati possano causare la dissoluzione del concetto di servizio pubblico. Le conclusioni sottolineano la necessita' di accelerare la privatizzazione dei servizi pubblici e la riforma della Corporate Governance come strumento per il raggiungimento dell'interesse generale. The role of 3D Helical CT in the reconstructive treatment of maxillofacial cancers; Tomografia Computerizzata spirale con elaborazioni tridimensionali di superficie nel trattamento ricostruttivo dei tumori maligni del massiccio facciale. De Rosa, V. Nazionale Tumori Fondazione G. Pascale, Naples Italy ; Parascandolo, S. Further Ti features are strength, biocompatibility and easy handling. The prospect is provided to identify virtual 3D presurgical ablation planes. These may allow the surgeon to improve plastic reconstruction and shorten intervention time. Sono state eseguite dal al 11 ricostruzioni plastiche dell'osso mascellare per neoplasie osteodestruenti il massiccio facciale utilizzando materiale alloplastico. Applicato nel cavo residuo dell'osso un otturatore siliconato sormontante una protesi acrilica con arcata dentaria per la ricostruzione del palato. In due casi utilizzato pericardio bovino modulato sulla soluzione di continuo. Tutti i pazienti sono stati studiati con TC spirale sia nella fase preoperatoria che entro il sesto mese dall'intervento chirurgico. L'elaborazione tridimensionale della superificie sui dati ottenuti con acquisizione volumetrica ha fornito in tutti casi la fedele. Usual interstitial pneumonitis UIP presenting with Wells grade 3. Can imaging methods help predict further progression of disease? Fasano, L. Servizio di Medicina Nucleare; Battista, G. Three different grades of idiopathic pulmonary fibrosis can be identified by HRCT pattern. Patients with predominant ground-glass opacity grade 1 usually improve after treatment and may have a better prognosis. The subjects with a predominant reticular pattern and honeycombing grade 3. Nevertheless, these patients may worsen even in the absence of HRCT features of the so-called alveolitis. The aim of this report is to investigate the predictive role of some noninvasive imaging methods HRCT with visual score of disease extent; Gallium scintigraphy; DTPA scintigraphy in patients with idiopathic fibrosis and a prevalent macroscopic fibrosis at HRCT study. La fibrosi irreversibile tuttavia non e' necessariamente una situazione stabile ma puo progredire ed evolvere ulteriormente. In particolare i pazienti che gia all'esordio presentano solo i segni della fibrosi possono peggiorare a distanza di tempo nonostante la terapia. Scopo del lavoro e' stato quello di individuare in un gruppo di pazienti con prevalente fibrosi macroscopica quale possa essere un parametro preditivo della successiva evoluzione della malattia. Abdominal adipose tissue distribution in obese children. US versus CT measurements; Valutazione della distribuzione del tessuto adiposo addominale nei bambini obesi. Confronto tra ecografia e Tomografia Computerizzata. Ferrozzi, F. Clinica Pediatrica; Campani, R. Con l'ecografia sono state valutate le distanze tra il muscolo retto e la colonna vertebrale e tra il muscolo retto e l'aorta, senza e con compressione dosata, quali parametri indicativi dello spessore del grasso viscerale nonche' la distanza tra cute e muscolo retto quale indicatore del grasso sottocutaneo. I risultati dell'ecografia e della TC sono stati inoltre correlati con altre variabili morfometriche peso, peso corporeo ideale, plicometria cutanea. De acuerdo al Servicio. Sismológico Nacional SSN , el epicentro se ubicó a kilómetros al suroeste de Ciudad Hidalgo, en el municipio de Suchiate, segundos después de las horas. En los primeros 23 días de Abril, Chiapas ha sido escenario de temblores, mientras que en al año se han contabilizado mil , es decir, un promedio cercano a los diez diarios. Por lo mismo, la Comisión Nacional del Agua Conagua hizo un estudio técnico y concluyó que la red, ubicada en la prolongación de la 17 Oriente, debería reconstruirse, pero evitando el afluente. Los recursos que se requerían para corregir la obra fueron autorizados por el Gobierno Federal y ya se iniciaron los trabajos. La autorización de la obra que hizo la Conagua y las acciones que lleva a cabo,. De acuerdo a la opinión de Martínez López, si se continuaba dejando la red en el mismo lecho del río se iba a seguir contaminando y corría el riesgo de dañarse por alguna inundación. Así también, que la mejor alternativa, a criterio de la Conagua, fue pasarla por arriba de la banqueta y cubrir la. Esa técnica ya se ha hecho en otros puntos de la ciudad, en. Se desconoce si. En entrevista para EL ORBE, reconoció la importancia del transporte colectivo por la necesidad que tienen de trasladarse desde sus comunidades hacia cualquier punto del municipio y viceversa, sobre todo para realizar la compra de alimentos y medicinas, o para ir al trabajo. Cabe señalar que en el documento se incluyen nueve. Durante una reunión virtual de la mesa técnica, la diputada Barrera Badillo destacó la importancia de que los legisladores revisen la propuesta de dictamen y emitan sus consideraciones, para procesarlas y se apruebe, una vez que se reanuden las actividades presenciales. También, la mesa técnica. Comunicado de Prensa. En entrevista exclusiva para EL ORBE reveló que tienen conocimiento de que hay muchos migrante infectados en Estados Unidos, tanto libres como asegurados en centros de detención. Ahí hay al menos 20 migrantes detenidos que han dado positivo a la pandemia, pero que lo. En esa misma ciudad hay otras 15 persona que ya dieron positivo, pero no se sabe como fue el mecanismo de contagio y si tuvieron algo que ver los migrantes. En el caso de Tapachula, indicó que tuvieron conocimiento de un migrante retenido en la Estación Migratoria Siglo XXI y que, por lo mismo, solicitaron informes al Instituto Nacional de Migración INM , pero que no les quisieron dar respuestas. Entrevistado a un costado de la alcaldía, indicó que los migrantes se sienten protegidos por los convenios que ha hecho el gobierno federal mexicano con la Organización de las Naciones Unidas ONU de abrir las puertas del país y hasta mantenerlos con subsidios económicos. Hasta ayer 23 de Abril, se reportaron en Italia , casos de infectados, 25, de muertos y 57, recuperados. Asimismo, se informó de nuevos pacientes recuperados. Italia se encuentra en el puesto 3 de países con mayor cantidad de infectados. De las , personas actualmente positivas, 81, se encuentran en aislamiento domiciliario, 22, internadas con síntomas y en terapia intensiva. En entrevista, Ramírez Leal comentó que en la construcción del Aeropuerto Internacional de Santa Lucía hay una gran oportunidad de emplear a trabajadores de constructoras formales que pagan impuestos. Pero las constructoras han sido desplazadas de. Ramírez Leal dijo que las constructoras han sido estigmatizadas debido a que algunas empresas nacionales y extranjeras abusaron en sexenios pasados, por lo que dejaron hospitales y carreteras a medias, o como en el Tren. En este marco, Llaven Abarca señaló que la asociación ciudadana de manera imparcial y transparente en su reporte correspondiente a los meses de Enero, Febrero y Marzo, informó que Chiapas junto con Baja California Sur y Sinaloa fueron los Estados mejores evaluados por el índice de sus indicadores delictivos. Diabetes, hipertensión, obesidad y tabaquismo son las enfermedades que. Veracruz, Sinaloa y Nayarit son Estados con un panorama similar. Reconocemos en la prevención la vía para evitar la muerte y la desolación. Se precisa unidad para afrontar los desafíos económicos. En los tres, la hipertensión es el mayor riesgo para los pacientes. Reiteró que la extensión de la Jornada Nacional de Sana Distancia hasta finales de Mayo, tiene como objetivo reducir en mayor medida la afectación a la población, por ello es fundamental que la sociedad colabore y de esa manera no saturar los servicios de salud. Comentó que sumado a la convocatoria de permanecer en el hogar, es fundamental organizarse con los integrantes de la familia para que sea un solo miembro el que salga a realizar la compra de alimentos, medicinas y productos de primera necesidad, pero tomando todas las medidas de protección. M éxico. La mitad de estas personas -unas mil- acudiría a atención médica y alrededor de 10 mil requerirían terapia intensiva. Expuso que Locatel, a través de los mensajes SMS, ha atendido mil cuestionarios completados; de estos, 3 mil se han reconocido como sospechoso y este miércoles hubo traslados; 41 de Cruz Roja, 81 del ERUM, cuatro de ambulancias particulares, dos de las alcaldías y ocho de la Secretaría de Salud. Viernes 24 de Abril de De la intensa conferencia matutina de antier miércoles 22 y en lo referido a la crítica a la prensa crítica, valdría el esfuerzo histórico para hacer unas precisiones referidas a caracterizaciones de periodistas buenos y periodistas malos. Los hermanos Flores Magón usaron su periódico Regeneración como espacio militante en la lucha del Partido Liberal contra Díaz, padrino de bautizo, por cierto, de uno de ellos; por lo tanto, se trató de un periodismo parcial, partidista, excluyente, ideológico y El revolucionario. Me ha tocado criticar, comentar y cuestionar, desde este espacio, las acciones, dichos y decisiones Escojan: hay Periodismo de Estado, de Militancia e Independiente Crítico Tapachula, Chiapas. Viernes 24 de Abril de La psicosis en la población mundial se incrementa con la noticia de que dos gatos resultaron positivos por Coronavirus en Nueva York, Estados Unidos. Ciertamente, el decreto del 21 de Abril no crece los programas ni tampoco el padrón de sus Oscar D. Y el Presidente tiene la obligación constitucional de ver por todos y no solo por una parte de los afectados. Tasa de letalidad global: 6. La OMS clasifica la distribución de casos por regiones. Fuente: Ssa Tapachula, Chiapas. Durante su participación, el presidente de la Junta de Coordinación Política del Congreso, Marcelo Toledo Cruz, reconoció la solidaridad del Poder Legislativo al aprobar, por unanimidad, la autorización para que las y los alcaldes destinen hasta 25 por ciento de los recursos del Fondo General de Participaciones del Ramo General 28, el 10 por ciento de ingresos libres de los recursos presupuestales del ejercicio , y hasta el 5 por ciento del Fondo de Aportaciones al Fortalecimiento Municipal. Especialidad - Enfermedades del corazón - Hipertensión arterial - Electrocardiogramas - Ecocardiogramas: bidemensional - Doppler color, continuo y pulsado. Oriente No. SSA NO. DE AUT. T apachula, Chiapas; 23 de abril. Ante estos hechos se presentó la denuncia ante las autoridades ministeriales, para que inicien las investigaciones y determinen quién de los empleados tomó ese dinero, para que sea castigado. Las fuertes llamas envolvieron la caseta que estaba construida de madera, quedando reducido a cenizas, en donde se presume que un corto circuito dio inicio a la conflagración. A pesar de la intensidad del fuego, no se reportaron personas lesionadas ni intoxicadas, por lo que después de varios minutos de trabajo, se logró controlar la situación. SUN C hile; 23 de abril. Solicitó al Emergencias, la presencia de las diferentes corporaciones policiacas, quienes arribaron al lugar y después de verificar los hechos revisaron a la persona que se encontraba a un costado de la cama y confirmaron que estaba sin vida. Al arribar esta mañana después de estar tocando y no recibir respuesta, abrió el negocio con sus llaves y lo encontró tirado, desnudo y boca abajo. Presuntamente se debió al exceso de velocidad al que una persona conducía un automóvil Volkswagen Jetta de color azul, con placas de circulación del estado de Chiapas y eso provocó que al pasar por una curva perdiera el control y volcara. Roberto Armas Guillén U. Centro, Tapachula, Chis. Bastante amplio, en excelente ubicación en pleno centro de la ciudad. Edgar V. Teléfono , Por expansión solicita: Choferes Vendedores Requisitos: - Con experiencia - Solicitud de empleo requisitada - Estudios mínimos preparatoria - Dos cartas de recomendación - Comprobante de domicilio - Licencia de manejo vigente - INE - Acta de nacimiento - Constancia de no antecedentes penales Interesados comunicarse al Teléfono 62 ó al Celular , o acudir a entrevista en 3a. Viernes 24 de Abril de La Pontificia Universidad Católica de Chile ofrece este programa de 8 horas de duración que describe los principales componentes de la gestión de proyectos sin pérdidas lean project management. Norte, Col. Clínica Santa María Lic. Avenida Norte 86 Entre 13a. Poniente Col. Fanny J. Gómez Ozuna Céd. Poniente, Tapachula, Chiapas. Ana Aurora Lugo Pon. Luis A. Santiago Martínez Celular: 36 Oscar Antonio Alfaro Camas Atención para niños, adolescentes y adultos 11a. Sur No. E stados Unidos; 23 de abril. Por Arturo V. Órbita de Estrellas Por Arturo V. Sun Tapachula, Chiapas. Viernes 24 de Abril de Grandes Ligas Sanciona a Red Sox por Robo de Señales El terremoto que hace unos meses azotó a los Astros de Houston por robo de señales en la temporada tuvo este miércoles una réplica de menor intensidad, pero en Boston. En este sentido, con la compra del operador de cable, Vodafone, que se encuentra inmersa en el despliegue de una red de fibra conjunta con Orange, aumentaría de forma inmediata su alcance en el mercado fijo en España. Vodafone cuenta actualmente con cerca de 14 millones de clientes de telefonía móvil y unos .

LEO 23 julio agosto. No permitas que los malos entendidos enfríen las relaciones con tu pareja, pues lo que no se aclara hiere. En esta cuarentena muchos artistas han link su tiempo de diferentes formas y Shakira no es la excepción, ya que a pesar de tener sus proyectos musicales decidió experimentar algo nuevo.

También aseguro que tomar este curso fue un poco difícil ya que lo hacía mientras sus pequeños hijos descansaban, así Vittorio colao esposa disfunción sexual aprovechaba el tiempo.

Shakira Vittorio colao esposa disfunción sexual cuatro fotos en su cuenta de Instagram en las cuales se le ve sonriente con su diploma. VIRGO 23 agosto septiembre. LIBRA 22 septiembre octubre. En exclusiva para Grupo Cantón, el artista dio los detalles del final de la serie estelar de Televisa. Mi personaje lució muy bien y al final tuvimos que resolver de la mejor manera y acabar de una forma distinta, pero quedó muy bien.

En un Vittorio colao esposa disfunción sexual. La serie fue grabada a través de 41 países durante días y gracias a la ayuda de drones presenta espacios desconocidos. Ya se ha comprobado como a través de las redes sociales se pueden propagar rumores y noticias falsas que pueden alterar el orden social. Por ejemplo, en Reino Unido creció una campaña en la que se acusaba a las antenas celulares 5G de propagar el Covid, lo que llevó a un grupo de personas a bandalizarlas.

Twitter también dijo haber. Editorial, que este año tiene como objetivo llegar a mil minutos leídos, no superaban los mil minutos un día antes de que el reto termine. En el marco del Día Mundial del Libro, que el 23 de abril suele celebrarse con una gran cantidad de actividades literarias, maratones de lectura, Vittorio colao esposa disfunción sexual de libros y toda una fiesta alrededor del libro y la lectura, ofrecemos una mirada sobre cómo ha afectado esta pandemia a la industria editorial y cómo el Estado mexicano no ha planteado opciones de apoyo al gremio.

Roberto Banchik, director general de Penguin Vittorio colao esposa disfunción sexual House México, asegura que van un poco como los alcohólicos, día con día, porque todo puede cambiar; dice que hasta febrero hacían proyecciones a meses e incluso a un año o dos, pero esta pandemia ha cambiado todo. Algunas opciones Esa es la preocupación del gremio de editores y de libreros Vittorio colao esposa disfunción sexual general. El terremoto que click at this page unos meses azotó a los Astros de Houston por robo source señales en la temporada tuvo este miércoles una réplica de menor intensidad, pero en Boston.

Las Grandes Ligas dieron a conocer que culminó la investigación a los Red Sox por incurrir en dicha acción espionajeaunque llevada a cabo de modo distinto, durante la campañaen la que resultaron campeones.

Mediante un comunicado, el comisionado Rob Manfred detalló que las medidas adoptadas por Watkins no tuvieron el mismo impacto que las llevadas a cabo por el equipo de Houston un año antes. Necesitaba fortificar a los futbolistas mexicanos y Hugo ya era una figura internacional. En ese tiempo, Hugo dijo abiertamente que no volvería a la Selección, hasta que Maurer e Ibarra dejaran la Federación Mexicana de Futbol.

Hace muchísimos años México no lo era, y hoy compite con more info buenos jugadores.

Los participantes, que se conforman con sólo participar; los protagonistas y los candidatos. De acuerdo con medios locales, los directivos del balompié ibérico han analizado Vittorio colao esposa disfunción sexual el mejor panorama es que el resto de la temporada y la mitad de la que viene se dispute a puerta cerrada en los estadios. Lo que ya se piensa es en el retorno de los entrenamientos.

Vittorio colao esposa disfunción sexual

Ya me pasó la edad, me pasó esa presión. El mal learn more here por los Diablos Rojos le hizo reflexionar que su tiempo en los banquillos se terminó. In uno con andidride carbonica e' stata evidenziata una fistola artero-venosa iatrogena renale trattata con embolizzazione transcatetere.

Tutti i pazienti sono stati monitorati per le funzioni vitali pressione arteriosa, elettrocardiogramma, saturazione di ossigeno e sono state annotate le sensazioni riferite durante la procedura. In 9 angiografie delle arterie renali si e' avuta valida dimostrazione del tronco e delle branche principali ma scarsa visualizzazione delle arterie interlobari e arcuate. Si e' ottenuta soddisfacente visualizzazione in 5 delle 7 procedure Vittorio colao esposa disfunción sexual per la valutazione del circolo periferico, mentre in 2 si e' avuta incompleta opacizzazione dell'aorta addominale e delle arterie iliache.

Lo studio del distretto venoso si e' rivelato sempre valido. Inoltre Vittorio colao esposa disfunción sexual della fistola artero-venosa iatrogena renale e' stata eccellente. L'impiego dell'anidride carbonica e' particolarmente indicato Vittorio colao esposa disfunción sexual pazienti a rischio per reazioni allergiche ai mdc iodati e in quelli con funzionalita' renale alterata oltre ad agevolare l'esecuzione di particolari procedure interventistiche quali.

Dobutamine cine magnetic resonance imaging after myocardial Vittorio colao esposa disfunción sexual Cine Risonanza Magnetica con dobutamina dopo infarto del miocardio.

Giovagnoni, A. Scienze Radiologiche, Dipt. Cattedra di Cardiologia; Rossi, R. Scopo dello studio e' quello di verificare la validita' diagnostica della cine RM con stimolo farmacologico in confronto con l'ecocardiografia con stimolo farmacologico nella valutazione della vitalita' del miocardio e di proporre un nuovo metodo d'analisi delle immagini di cine RM mediante la sottrazione elettronica d'immagine al fine di ridurre gli elementi soggettivi nella valutazione quantitativa dell'ispessimento parietale.

Ventisei pazienti 21 maschi, 5 femmine con pregresso infarto del miocardio in attesa di intervento di rivascolarizzazione sono stati sottoposti a ecocardiografia con stimolo farmacologico mediante dobutamina e a esame cine RM con dobutamina al fine di verificare la ripresa contrattile dei segmenti giudicati acinetici o ipocinetici all'esame ecocardiografico di base.

Per ogni Vittorio colao esposa disfunción sexual sono stati considerati 16 segmenti del ventricolo sinistro. Nel totale di segmenti Vittorio colao esposa disfunción sexual considerati l'analisi qualitativa del movimento parietale con ecocardiografia con dobutamina ha dimostrato segmenti normocinetici, 64 cicatriziali e 45 vitali mentre con la cine Rm sono stati osservati rispettivamente segmenti come normocinetici, 83 cicatriziali e 31 vitali. Tre mesi dopo l'intervento di rivascolarizzazione 15 pazienti sono stati rivalutati Vittorio colao esposa disfunción sexual verificare la ripresa contrattile dei segmenti giudicati vitali.

Nei pazienti con infarto anterosettale l. Incidenza di meningiti nell'ASL di Brescia nei primi mesi del Tali tassi sono stati confrontati con i tassi corrispondenti nei primi mesi del Risultati : nel primi 5 mesi del si sono registrati in tutto 48 casi, di cui 9 da meningocco, 13 Vittorio colao esposa disfunción sexual pneumococco, 14 virali, 3 da altri agenti batterici e 8 senza agente microbico identificato.

Identificazione delle specie batteriche della placca subgengivale quale fattore di rischio per patologie parodontali in donne con variazioni ormonali fisiologiche e parafisiologiche. I principali obiettivi di questo studio sono stati quelli di valutare le implicazioni della menopausa sulla salute orale, nelle pazienti in trattamento con TOS terapia Vittorio colao esposa disfunción sexual sostitutiva o meno, con particolare riferimento a modificazioni quali-quantitative dei principali batteri patogeni parodontali, che possono portare ad alterazioni dell equilibrio omeostatico del microbiota a favore di alcune specie più frequentemente coinvolte nell eziopatogenesi delle parodontopatie.

A tal Vittorio colao esposa disfunción sexual, Liver trauma from penetrating injuries. Miscellanea, personal series, clinical and CT findings; Traumi epatici da lesioni penetranti.

Miscellanea, casistica personale, aspetti clinici e con Tomografia Computerizzata. Moreover, Helical CT could provide the click diagnosis of active bleeding in the peritoneum and of focal bleeding in the liver, thus permitting prompt hepatorrraphy or targeted hepatectomy. A diaphragm injury suspected at CT should always prompt the surgeon to intervention, especially when hemothorax, lung base pneumothorax, large liver hematoma or tear of the liver dome are associated.

Finally, subdiaphragmatic free gas indicates gut perforation associated with liver damage, in which case surgery is necessary too. Scopo del lavoro e' di illustrare i vari quadri clinico-radiologici della nostra casistica personale, determinati da lesioni penetranti da armi da fuoco e da punta e taglio. Definire inoltre la modalita' di diagnosi, soprattutto in base ai segni TC del danno epatico e di lesioni associate, che condizionano in modo decisivo la terapia e l'approccio chirurgico o conservativo.

Negli ultimi sette anni sono stati studiati retrospettivamente 31 casi 19 maschi e 12 femmine; eta' media 42 anni, compresa Vittorio colao esposa disfunción sexual 18 e 73 annicon check this out penetranti del fegato, dovute prevalentemente a armi da fuoco 16 pazientia armi da punta e taglio 9 casi e miscellanee in 6.

L'esame TC dell'addome e' stato eseguito in emergenza e con tecnica angio-TC in tutti i pazienti. Nei casi di ferite con sospetto coinvolgimento toraco-addominale, la TC veniva iniziata dal medio-torace al fine di una valutazione accurata del diaframma, delle basi polmonari e per escludere lesioni pleuropolmonari associate.

Fra tradizione e sperimentazione: tecniche narrative nei racconti di Fra tradizione e sperimentazione: tecniche narrative nei racconti di Paola Capriolo. R Wilson, V Gerrand. Contemporary novelists have responded in different ways to the challenge of living and writing in the latter half of the twentieth century, a historical moment in which the paper and ink with which they have Neurofibromatosis 1 NF1 is an autosomal dominant condition characterized by neuro-cutaneous involvement and a predisposition to tumour development.

Resting-state fMRI has recently emerged as a powerful tool for functional brain analysis, allowing the examination Valutazione dello spostamento tridimensionale degli impianti in giovani pazienti affetti da EDs riabilitati con overdenture implanto-supportati.

Ectodermal Dysplasias syndrome EDs are a heterogeneous group of inherited disorders characterized by dysplasia of tissues of ectodermal origin. Complete or partial anodontia are continue reading most frequent dental findings.

Prosthetic rehabilitation is recommended from functional, esthetic, and psychological points of view. Because of the anatomical abnormalities of existing teeth and alveolar ridges, conventional prosthetic rehabilitation in young patient is often difficult.

Five growing patients ag Il diritto alla salute dei migranti nei Paesi Bassi. The increased prevalence of drug resistant Vittorio colao esposa disfunción sexual of Mycobacterium tuberculosis Mtb indicates that significant mutagenesis occurs during tuberculosis disease in humans. In this study we assess the contribution of Nei and Nth DNA repair enzymes in Mycobacterium smegmatis Msmwhich retains a single nth homologue and duplications of the Fpg fpg1 and fpg2 and Nei nei 1 and nei 2 homologues.

Using an Escherichia coli nth deletion mutant, we confirm the functionality of the mycobacterial nth gene in the base excision repair pathway. Msm mutants lacking nei 1, nei 2 and nth individually or in combination did not display aberrant growth in broth culture. Deletion of nth individually results in increased UV-induced mutagenesis and combinatorial deletion with the nei homologues results in reduced survival under oxidative stress conditions and an increase in spontaneous mutagenesis to rifampicin.

Furthermore, no differential emergence of the common rifampicin resistance conferring genotypes were noted. Collectively, these data confirm a role for Nth in base excision repair in mycobacteria and further highlight a novel interplay between the Nth and Nei homologues in spontaneous mutagenesis. All rights reserved. Le norme statali in materia di tutela penale dei culti e del sentimento religioso. Alcune sommarie considerazioni. Chiacchierare con le immagini, l'uso delle fotografie nei servizi di microblogging.

Images and Vittorio colao esposa disfunción sexual content in general constitute a large part of online communication. This chapter attempts a first analysis of the role played by images within a microblogging platform Vittorio colao esposa disfunción sexual three categories: self-portraits, please click for source generated content, and screenshots The map service was created for inclusion Parlare con le immagini.

Come i media possono ridare voce a persone affette da afasia. Neuropeptide glutamic acid-isoleucine NEI -induced paradoxical sleep in rats. Neuropeptideglutamic acid-isoleucine NEI as well as melanin concentrating hormone MCH is cleaved from the amino acid protein, prepro-melanin concentrating hormone prepro-MCH. However, there are no studies on the effect of NEI on the sleep-wake cycle. Vittorio colao esposa disfunción sexual injection of NEI 0.

Sezary syndrome SS is a rare primay epidermotropic cutaneous T-cell lymphoma in leukemic. The aetiopathogenesis of MF and SS remains obscure despite several investigations. Infectious, environmental and genetic factors have been implicated as potential aetiological agents. The different sensitivities of the technical methods used in the evaluation of the presence of viral DNA or virus-related antigens make comparison of the results difficult.

Skin biopsies were obtained from 21 MF and 10 SS patients; skin biopsies from a 8 patients with inflammatory skin disease were used as controls. EBV-negative patients even if not statistically significant. We are going to investigate the presence of EBV-DNA in peripheral blood of a larger number of patients and to evaluate the pattern of viral genes expression, to better assess the aetiopathogenetical role of EB virus in this kind of neoplasies.

Analisi delle antibiotico-resistenze di Gram-negativi isolati da pazienti con infezioni del tratto urinario afferenti al Polo Oncologico e Dermatologico I. Urinary tract infections represent a worlwide problem due to their prevalence among nosocomial infections and to the increasing frequency of antibiotic resistance among the Gram-negative pathogens.

Knowledge of the antimicrobial resistance patterns according to local epidemiology is essential for providing clinically appropriate therapy for urinary tract infection. In the present study we analysed the drug resistence pattern of Gram negative bacteria isolated from urine samples Full Text Available Introduction.

In the present study we analysed the drug resistence pattern of Gram negative bacteria isolated Vittorio colao esposa disfunción sexual urine samples of patients with urinary tract infections at the Microbiological Laboratory of I.

Materials and Methods. A Vittorio colao esposa disfunción sexual isolates have been collected during three years Isolates were subcultured to Agar blood-Mac-Conckey and analysed in the Vitek 1 for identification and drug susceptibility. Proteus mirabilis, Klebsiella pneumoniae, and Pseudomonas aeruginosa, were less frequently isolated 9.

The E. The P. The increased drug resistance developed by bacteria consistently due to previous treatments with several antimicrobial drugs makes it essential the culture and susceptibility testing in genitourinary tract infection before instituting antimicrobial therapy.

Empirical antimicrobial therapy should be avoided or reassessed by 48 to 72 hours after initation based on preterapy culture results. Metodi Vittorio colao esposa disfunción sexual in uno studio retrospettivo sono stati analizzati campioni di siero Vittorio colao esposa disfunción sexual da 34 soggetti 27M, 7F; età media Mutazioni nel gene S sembrano correlare con il genotipo D e la tossicodipendenza. The baseline methodology of NEI is composed of break this web page, debris generation, latent debris, debris transport, and head loss.

Sexy song Watch Porn Movies Brezzers Sex. Salzano, A. Cardarelli, Naples Italy. Servizio di Neuroradiologia. Diagnosis on often late because clinical signs, laboratory data and radiologic findings are a specific. The authors investigated radiographic and particular CT patterns of intestinal infraction in 56 patients submitted to surgery within 12 hours of admission. We also report the CT findings of 5 of these patients who had reversible mesenteric ischemia. CT is more sensitive than radiography and does not exhibit the limitations of angiography i. Therefore CT can presently be considered the method of choice in patients with suspected bowel infarction. Il riconoscimento diagnostico e' tardivo per l'aspecificita' dei dati di laboratorio, dei segni clinici e degli esami radiologici. La TC presenta maggiore afficacia diagnostica rispetto all'esame radiografico diretto e non ha limiti che caratterizzano l'angiografia, quali l'invasivita', radioesposizione e complessita' organizzativa: attualmente la metodica TC puo' essere indicata come indagine di scelta in pazienti con sospetto infarto intestinale. Istituto di Radiologia. Conclusions: Vasoseal ES is a safe collagen device characterized by a high success rate. In anticoagulated patients the device can reduce the time to mobilisation and the incidence of complications. Materiale e metodi: Tra gennaio e marzo sono stati seseguiti accessi arteriosi transfemorali consecutivi in pazienti in 11 pazienti e' stato effettuato un accesso bilaterale sottoposti a procedure radiologiche vascolari: angioplastiche PTA e 40 chemioembolizzazioni TACE. Gli introduttori sono stati rimossi al termine delle manovre interventistiche e sulla superficie esterna dell'arteria sono state posizionate 2 cartucce di collagene; i valori medi di PTS e PTT erano rispettivamente Il giorno successivo e' stato effettuato uno studio ecografico con tecnica color-Doppler nel sito di puntura. Il tempo. Medline Plus. Full Text Available NEI is a national database of air NEI for Kids: Glossary. Emily Y. Chew, M. Radiodine treatment of hyperthyroidism with a simplified dosimetric approach. Clinical results; Terapia radiometabolica dell'ipertiroidismo con approccio dosimetrico semplificato. Risultati clinici. Giovanella, L. Cattedra di Medicina Nucleare, Ist. Tale attivita' minima e' stata quindi modulata in base ai dati clinici, laboratoristici e strumentali fino all'attivita' massima intra-tiroidea di MBq dopo 24 ore. I pazienti sono stati sottoposti a controllo clinico e laboristico 3 e 12 mesi dopo il trattamento, instaurando l'opportuna terapia tireo-sostitutiva nei casi di ipotiroidismo. Nei pazienti affetti da mrobo di Graves-Basedow e' stata somministrata una attivita' media di MBq distribuzione: MBq. Tre pazienti sono stati immediatamente sottoposti a secondo trattamento con radioiodio mentre 32 pazienti ipotiroidei hanno iniziato la terapia tireo-sostitutiva. Il risultato definitivo dopo 12 mesi e' stato di risoluzione del quadro di abstract truncated. Evoluzione dell' abitudine al fumo nei locali dellíAzienda Ospedaliera Universitaria Senese dal al Questo studio è stato ripetuto negli anni , e Conclusioni : la diminuzione costante del numero di fumatori in ospedale, mostra come ci sia stato negli ultimi anni un rispetto sempre maggiore del divieto di fumo nei luoghi di cura. Il coinvolgimento di futuri medici permette di promuovere il problema fumo in ospedale. Ferrando, R. Genua Italy. Per la defecografia tradizionale si e' utilizzato un apparecchio telecomandato e valutato le quattro fasi di: riposo, trattenimento, ponzamento e spinta. Per lo studio con TC e' stata eseguita acquisizione volumetrica spirale con collimazione del fascio di 5 mm, pitch 2, kV, m As e inclinazione del tunnel di scansione di gradi verso il paziente al fine di ottenere piani coronali del pavimento pelvico. Il paziente dotato di pannolone per adulti e' posizionato a cavalcioni del tavolo porta-paziente in posizione da motociclista, previa distensione dell'ampolla rettale con bolo fecale costituito da ml di mdc iodato non ionico con la diluizione di 3 g di iodio per ml. L'esame e' stato eseguito nella posizione supina nei casi nei quali i pazienti non riuscivano a mantenere la posizione. E' stata eseguita acquisizione volumetrica spirale di 20 secondi nella fase di riposo e di spinta con ricostruzioni multiplanari specie sul piano sagittale per il confronto con le immagini con la defecografia tradizionale. La defeco-TC ha consentito di evidenziare malattie estrinseche all'apparato ano-rettale, risultando esame di seconda istanza rispetto alla defecografia tradizionale ma dirimente nei casi dubbi per la possibilita' di valutare il trofismo dei muscoli deputati all'atto defecatorio e le strutture contigue attraverso le ricostruzioni multiplanari con alta risoluzione. Communication dustin. DeMott nih. Technical questions about this website Technical questions about this Technical questions about this website can be addressed MR study of the intrinsic acromial angle in 74 symptomatic patients; Studio RM dell'angolo intrinseco dell'acromion in 74 pazienti sintomatici. Servizio di radiologia. These parameters were found to be consistent and comparable with tue Bigliani classification of acromial morphology which, although providing useful qualitative data, does not fully respond to our quantitative needs. Our study suggests that impingement syndrome is negatively correlated to acromio-humeral distance and positively correlated to intrinsic acromial angle. These parameters, which are readily detected with MRI, may be used by the radiologist and orthopaedic surgeon to screen patients with nonspecific impingement syndrome. Lo scopo e stato quello di individuare un piano di scansione con alcune misurazioni associate che fornissero delle indicazioni quantitative sullo spazio subacromiale nei pazienti affetti di sindrome da impingement aspecifica. Settantaquattro pazienti 47 maschi, 27 femmine, eta compresa tra 35 e 62 anni che presentavano una sintomatologia da sospetta sindrome da impingement sono stati sottoposti al nostro studio. E stata adottata la classificazione di Bigliani per la morfologia dell'acromion confrontata con il nostro metodo di misura basato sulla rilevazione del valore espresso in gradi dell'angolo intrinseco dell'acromion e sulla misura della distanza acromion-omerale. I dati ricavati del valore dell'angolo risultano correlati alla classificazione di Bigliani. Nelle rotture parziali. This website is maintained by the Hays - Chief, Science Communication dustin. Caratterizzazione della flora microbica orale in diverse categorie di pazienti sindromici in età evolutiva. Ricerche sperimentali e cliniche hanno individuato i momenti eziopatogenetici delle diverse problematiche che si riscontrano a carico del cavo orale, con una frequenza superiore nei paz This website is DeMott, Media Relations Kathryn. Studio caso-controllo su pazienti affetti da legionellosi: risultati preliminari di una indagine multicentrica. Risultati : su 2. Tra i casi individuati, 60 sono stati reclutati per lo studio caso-controllo e sono stati associati a controlli, una parte affetti da polmonite diversa da legionellosi, una parte sani. Nei soggetti affetti da legionellosi, la ferritina serica era significativamente più elevata rispetto ai controlli, mentre il numero delle cellule natural killer era significativamente inferiore. Lo studio dei possibili fattori di rischio associati alla malattia non ha evidenziato differenze significative tra i casi ed i controlli per le abitudini personali e le condizioni espositive ambientali. Gli 8 casi nosocomiali sono stati individuati in 3 degli ospedali sorvegliati. Modified Mason's vertical banded gastroplasty. Radiological follow-up patients with morbid obesity; Ruolo della radiologia nella valutazione dei pazienti affetti da obesita' patologica sottoposti a gastroplastica verticale secondo Mason modificata. Studio di casi. Monteduro, F. Policlinico S. Orsola, Servizio Radiologia 2; Ghetti, A. Clinica Chirurgica 2. Nel presente lavoro venogno presentati i risultati del controllo radiologico postoperatorio condotto su pazienti sottoposti a gastroplastica verticale secondo Mason modificata. In pazienti sottoposti a gastroplastica verticale secondo Mason modificata sono state valutate mediante studio radiologico con pasto semiliquido e tecnica con mdc semplice le caratteristiche morfologiche, funzionali e volumetriche della tasca gastrica e le eventuali complicanze dell'intervento. Di questi pazienti erano femmine con eta' compresa tra 17 e 69 anni media 37 e 50 maschi con eta' compresa tra 19 a 64 anni media 36 ; il peso medio era di kg con intervallo da 78 a Solo nei pochi casi in cui e' risultata necessaria la valutazione dettagliata della mucosa del neostomaco e' stato utilizzato il doppio mdc on minime dosi di polvere effervescente. La valutazione e' stata effettuata dopo uno e 12 mesi dall'intervento. Controlli al di fuori di questo protocollo sono stati effettuati solo su precisa indicazione clinica per sospetta insorgenza di complicanze compreso il non adeguato calo ponderale. Nella nostra serie si sono osservate 9 complicanze precoci: edema persistente dello pseudopiloro 8 casi ed emorragia endogastrica un caso e 8 complicanze tardive: aderenza dello pseudopiloro al letto della colecisti un caso , formazione di pseudo-diverticolo della parete posteriore del neostomaco un caso , orizzontalizzazione del neostomaco 4 casi , deiscenza della sutura lineare 2 casi. In pazienti non si e' avuta nessuna complicanza con calo ponderale soddisfacente e volumetria del neostomaco uno e. Aortic non communicating dissections. A study with helical CT; Studio dell'ematoma intramurale aortico. Aspetti con Tomografia Computerizzata spirale. Midiri, M. Emergenze Trapianto d' Organo, Sez. Un paziente con ematoma di tipo A e' deceduto per tamponamento cardiaco qualche ora dopo la diagnosi TC. Sei pazienti 5 di tipo B e 1 di tipo A sono stati sottoposti a terapia medica con farmaci antiipertensivi e monitoraggio radiologico. Undici pazienti 6 di tipo A e 5 di tipo B sono stati sottoposti a intervento chirurgico di sostituzione protesica; di questi, 5 3 di tipo A e 2 di tipo B sono deceduti per complicazioni postoperatorie. L'indicazione all'intervento chirurgico nei 5 casi di ematoma tipo B si e' basata sull'insorgenza di dolore refrattario alla terapia antiipertensiva e insorgenza di complicazioni ischemiche degli organi addominali per interessamento delle maggiori arterie collaterali dell'aorta, mentre un caso di ematoma di tipo A e' stato trattato farmacologicamente poiche' considerato inoperabile. La diagnostica per immagini svolge un ruolo fondamentale nella diagnosi di ematoma intramurale ecografia transeso-fagea, TC, RM. The Nuclear Energy Institute NEI provided a brief discussion on the benefits of establishing a new regulatory framework. He suggested that a new paradigm in regulatory thinking is needed and stated that the reactor oversight process ROP serves as the appropriate basis for starting these discussions. It is suggested that new operating criteria, generic risk- informed and performance-based regulations be developed with associated design-specific and regulation-specific regulatory guides. The Nuclear Energy Institute NEI provided a brief presentation on the state of energy demand in the United States and discussed the improving economics for new nuclear power plants. He discussed the consolidation of companies under deregulation and the ability of these larger companies to undertake large capital projects such as nuclear power plant construction. He discussed efforts under way to support a new generation of plants but noted that there needs to be greater certainty in the licensing process. He discussed infrastructure challenges in terms of people, hardware, and services to support new and current plants. He stated that there needs to be fair and equitable licensing fees and decommissioning funding assurance for innovative modular designs such as the PBMR. He concluded that NRC challenges will include resolving 10 CFR Part 52 implementation issues, establishing an efficient and predictable process for siting, COL permits and inspection, and an increasing regulatory workload. Valutazione farmacoeconomica della prevenzione con picotamide vs acido acetilsalicilico dei pazienti diabetici con vasculopatia periferica. Full Text Available Type 2 diabetes mellitus DM and peripheral arterial disease PAD are two very relevant cardiovascular CV risk factors, which can often be found concurrently in the same patient. The DAVID trial, a double-blind, randomized, aspirin ASA-controlled study, has demonstrated that the use of picotamide, a thromboxane A2 synthase and receptor dual inhibitor, is associated with lesser CV morbidity and mortality in this type of patients in comparison to ASA, considered the standard antiplatelet agent. In order to estimate clinical and economic impacts of picotamide in the Italian health care setting, we developed a pharmacoeconomic model based on clinical data from DAVID and national economic parameters and demographics. The base case scenario, which reflects current prices and reimbursement policy i. This cost, however, is totally born by the patient, while the savings on health care expenditures for avoided events and less ASA benefit the national health service NHS. The availability of a theoretical model allowed to explore some alternative scenarios, that indicate that the ICER can be further lowered and the economical burden better distributed through policy changes. Voci zingare nei gerghi padani. II reperimento, condotto con rara competenza ed abbondanza di riscontri da C. Tagliavini e dallo stesso Menarini, riguarda le seguenti parole. Le affinita in questione sono dovute tanto alla simbiosi quanto alia convivenza prolungatasi a un periodo plurisecolare. Senza dubbio, possi. Full Text Available Objectives: Pulmonary infections by Gram-negative bacteria, as Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia, are the major cause of morbidity in Cystic Fibrosis patients. In the past decade, several pathogens as Alcaligenes spp and no tuberculosis mycobacteria have been recovered in these patients. Bacteria of genus Chryseobacterium are widespread Gram-negative microrganisms and involved in human infections. Aims of this study were to value the isolation frequency of Chryseobacterium strains in a cohort of Cystic Fibrosis patients, to investigate their antimicrobial sensibility and to establish possible clonal likeness between strains. Sputum samples were checked: for bacterial identification, selective media and commercial identification systems were used. The activity of antimicrobial agents was determined using diffusion and microdiluthion methods. Results:A total of 26 strains from 17 patients were isolated 7 C. Strains were resistant to cephalosporins and carbapenems; some were sensitive to ciprofloxacin, levofloxacin and trimethoprim-sulphamethoxazole. Macrorestriction analysis showed substantial heterogeneity among strains. Conclusions: Actually, the prognostic role of Chryseobacterium in Cystic Fibrosis is unclear and although the small number of isolations, it is need to be on the look out regard such microorganisms. The considerable resistance implies difficulties on therapeutic approach. Results of DNA-fingerprinting indicate no evidence of clonal likeness and then of patient-to-patient spread. Valutazione morfo-funzionale in pazienti ipertesi con stenosi dell'arteria renale. Renovascula hypertension is the most important and common cause of secondary hypertension. We studied 10 patients with arterial hypertension and different degrees of renal artery stenosis to assess the usefulness of dynamic radionuclide renography in evaluating renal perfusion and funcion, and to compare funcional radionuclide results to the morphological findings of renal angiography. Computer-assisted dynamic renal with 00m Tc diethylenetriaminepentaacetic acid DTPA and I orthoiodohippurate OIH , and renal artheriography were also employed in all patients. In all patients, radionuclide results matched angiography findings in quality. In particular, 3 patients with hemodynamical insignificant renal artery stenosis exhibited normal perfusion and function at dynamic radionuclide renography. Seven patients had significant renal artery stenosis and associated functional changes at dynamic radionuclide renography. Relazione tra albuminemia e tessuto adiposo nei pazienti in trattamento dialitico. Metodi: Campioni di tessuto adiposo sono stati prelevati da soggetti sani e infiammati. Evidence based medicine EBM and evidence based radiology EBR in the follow-up of the patients after surgery for lung and colon-rectal carcinoma; Medicina basata sulle evidenze EMB e radiologia basata sulle evidenze EBR nel follow-up dei pazienti operati per tumore del polmone e del colon. Azienda ospedaliera Umberto I, Istituto di radiologia, oncologia clinica. Conclusions: Our findings can serve as a basis to start a discussion within the scientific community about the role of radiological follow-up in cancer patients with the aim of defining a more rational use of resources. Materiale e metodi: Sono stati ricercati utilizzando banche dati tradizionali e di editoria secondaria i lavori scientifici e le linee guida degli ultimi dieci anni inerenti l'impatto clinico dell'imaging nel follow-up dei pazienti con tumori solidi polmone, colon. Utilizzando la metodologia delle revisioni sistematiche proprie della EBM. Sono stati scelti i lavori piu significativi per numero di pazienti inclusi e livello di affidabilita. Sono stati valutati i seguenti parametri: timing delle indagini, sopravvivenza, periodo libero di malattia, qualita della vita, morbilita indotta, costi, aspetti psicologici. In una seconda fase stato analizzato retrospettivamente il follow-up clinico strumentale di 40 pazienti consecutivi affetti da tumore del colon 20 pazienti e polmone 20 pazienti giunti alla nostra osservazione nel periodo , valutato il costo reale e confrontato con quello teorico. Risultati: La revisione sistematica della letteratura ha permesso di. Evaluation of a new delivery system; Angiografia con anidride carbonica. Nuovo sistema di iniezione. Nicolini, A. In 9 pazienti sono state valutate le arterie renali, in 18 la pervieta' portale, in 7 il circolo arterioro periferico, in 4 le vene degli arti. In uno con andidride carbonica e' stata evidenziata una fistola artero-venosa iatrogena renale trattata con embolizzazione transcatetere. Tutti i pazienti sono stati monitorati per le funzioni vitali pressione arteriosa, elettrocardiogramma, saturazione di ossigeno e sono state annotate le sensazioni riferite durante la procedura. In 9 angiografie delle arterie renali si e' avuta valida dimostrazione del tronco e delle branche principali ma scarsa visualizzazione delle arterie interlobari e arcuate. Metagenomic sequencing of serum samples identified four additional APPV-positive samples. The molecular and serological results suggest that APPV is a novel, highly divergent porcine pestivirus widely distributed in US pigs. Genetic and antigenic characterization of novel pestivirus genotypes: implications for classification. To further address the issue of heterogeneity of pestiviruses we have determined the entire N pro and E2 coding sequences for several new pestivirus isolates. Interestingly, phylogenetic analysis revealed that one pestivirus isolated in the s in Africa is closely related to strain H Moreover, several novel pestiviruses isolated from sheep group together with the previously described strain V60 Reindeer-1 isolated from a reindeer, whereas one ovine pestivirus strain Gifhorn significantly differs from all previously described pestiviruses , including BDV. As an additional criterion for segregation of pestiviruses , the antigenic relatedness of pestivirus isolates covering all observed major genotypes was studied by cross-neutralization assays. Taking into account the host origin, the lack of differences concerning the course of disease, and the results of our genetic and antigenic analyses, we suggest that BDV-1, BDV-2, and BDV-3 should be considered as major genotypes within the species BDV. A nested PCR approach for unambiguous typing of pestiviruses infecting cattle. An atypical pestivirus 'Hobi'-like pestivirus , putative bovine viral diarrhoea 3, BVDV-3 was identified firstly in contaminated foetal calf serum batches and isolated subsequently from an outbreak of respiratory disease in a cattle herd in Italy. The isolation of the novel pestivirus from animals affected clinically posed concerns about the validity of BVDV eradication programs, considering that 'Hobi'-like pestivirus BVDV-3 is undetected or mistyped by the molecular diagnostic tools currently employed. In this paper, the development of a nested PCR nPCR assay for unambiguous typing of all bovine pestiviruses is reported. The assay consisted of a first-round amplification using an oligonucleotide pair which binds to conserved sequences located in the 5' untranslated region and capsid gene, followed by a heminested PCR using virus-specific forward primers. The assay performances were evaluated analytically, showing good sensitivity and specificity. Sequence analysis of the first-round amplification products showed that the untyped strains were border disease viruses, whereas the other three strains were true 'Hobi'-like viruses. The development of a molecular assay able to identify simultaneously all bovine pestiviruses known currently will help warrant biosafety of live vaccines and other biological products and assess the molecular epidemiology of 'Hobi'-like pestivirus , thus leading to the improvement of the eradication programs through unambiguous typing of pestiviruses infecting cattle. Detection and identification of the atypical bovine pestiviruses in commercial foetal bovine serum batches. Full Text Available The recently emerging atypical bovine pestiviruses have been detected in commercial foetal bovine serum FBS of mainly South American origin so far. It is unclear how widely the viruses are presented in commercial FBS of different geographic origins. To further investigate the possible pestivirus contamination of commercially available FBS batches, 33 batches of FBS were obtained from ten suppliers and analysed in this study for the presence of both the recognised and the atypical bovine pestiviruses. The atypical pestiviruses were detected in 13 batches claimed to originate from five countries. Analysis of partial 5'UTR sequences showed a high similarity among these atypical bovine pestiviruses. This study has demonstrated, for the first time that commercial FBS batches of different geographic origins are contaminated not only with the recognised species BVDV-1 and BVDV-2, but also with the emerging atypical bovine pestiviruses. Recently, atypical pestiviruses 'HoBi'-like pestiviruses were identified in batches of contaminated foetal calf serum and in naturally infected cattle with and without clinical symptoms. Here, we describe the first report of a mucosal disease-like clinical presentation MD associated with a 'HoBi'-like pestivirus occurring in a cattle herd. The outbreak was investigated using immunohistochemistry, antibody detection, viral isolation and RT-PCR. The main clinical signs and lesions were observed in the respiratory and digestive systems, but skin lesions and corneal opacity were also observed. MD characteristic lesions and a pestivirus with cytopathic biotype were detected in one calf. The present study is the first report of a MD like presentation associated with natural infection with 'HoBi'-like pestivirus. This report describes the clinical signs and provides a pathologic framework of an outbreak associated with at least two different 'HoBi'-like strains. Based on these observations, it appears that these atypical pestiviruses are most likely underdiagnosed in Brazilian cattle. In China, although the detections of HoBi-like pestivirus have been reported, the epidemiological investigation was limited. To test whether it is the HoBi-like pestivirus caused this symptom, 49 serum samples and 22 nasal swabs were then collected for analysis by serology and RT-PCR. Serological result revealed that prevalence of pestivirus in small ruminants was Mechanism of action of a pestivirus antiviral compound. Baginski, Scott G. We report here the discovery of a small molecule inhibitor of pestivirus replication. However, the compound shows no activity against viruses from unrelated virus groups. Time of drug addition studies indicated that VP acts after virus adsorption and penetration and before virus assembly and release. Analysis of viral macromolecular synthesis showed VP had no effect on viral protein synthesis or polyprotein processing but did inhibit viral RNA synthesis. When this single amino acid change was introduced into an infectious clone of drug-sensitive wild-type WT BVDV-1, replication of the resulting virus was resistant to VP This work formally validates NS5B as a target for antiviral drug discovery and development. The utility of VP and similar compounds for the control of pestivirus diseases, and for hepatitis C virus drug discovery efforts, is discussed. Virulence, immunogenicity and vaccine properties of a novel chimeric pestivirus. A chimeric pestivirus of border disease virus Gifhorn and bovine viral diarrhea virus CP7 Meyers et al. Virulence, immunogenicity and vaccine properties of the chimeric virus were studied in a vaccination—challenge experiment in pigs. The chimeric virus proved The safety of the vaccine was tested by horizontal transmission to sentinel pigs, which remained uninfected. The vaccine efficacy was examined by challenge infection with classical swine fever virus CSFV Eystrup El reverso de lo monumental. Memorial de los Veteranos de Vietnam. Pestivirus is a common contaminant in maedi-visna and caprine arthritis-encephalitis virus stocks. Eight different laboratory stocks of maedi-visna or caprine arthritis-encephalitis virus were examined for the presence of pestiviruses by a fixed-cell immunoperoxidase assay with polyclonal and monoclonal antibodies. All of the viral stocks examined were found to contain noncytopathic pestivirus contaminants. The panel of monoclonal antibodies could not type the isolates as being more related to bovine virus diarrhea virus or border disease virus. However, the results did indicate that all isolates were not the same, except for two from the same laboratory where the source of pestivirus contamination may have been common. Full Text Available Discusses a cabinet door to save a custody and paintings of the Last Supper and the Ascension that are painted on it on the sides: these paintings are attributed to Matías Aguirre. Se estudia una puerta de armario para guardar una custodia y las pinturas de la Cena y la Ascensión que aparecen pintadas en ella en el anverso y reverso : estas pinturas se atribuyen a Matías de Aguirre. Full Text Available Pestiviruses , which include economically important animal pathogens such as bovine viral diarrhea virus and classical swine fever virus, possess three envelope glycoproteins, namely Erns, E1, and E2. This article discusses the structures and functions of these glycoproteins and their effects on viral pathogenicity in cells in culture and in animal hosts. E2 is the most important structural protein as it interacts with cell surface receptors that determine cell tropism and induces neutralizing antibody and cytotoxic T-lymphocyte responses. All three glycoproteins are involved in virus attachment and entry into target cells. E1-E2 heterodimers are essential for viral entry and infectivity. Erns is unique because it possesses intrinsic ribonuclease RNase activity that can inhibit the production of type I interferons and assist in the development of persistent infections. These glycoproteins are localized to the virion surface; however, variations in amino acids and antigenic structures, disulfide bond formation, glycosylation, and RNase activity can ultimately affect the virulence of pestiviruses in animals. Along with mutations that are driven by selection pressure, antigenic differences in glycoproteins influence the efficacy of vaccines and determine the appropriateness of the vaccines that are currently being used in the field. Pestiviruses , which include economically important animal pathogens such as bovine viral diarrhea virus and classical swine fever virus, possess three envelope glycoproteins, namely Erns, E1, and E2. Recently, a putative new pestivirus species, provisionally named as Atypical Porcine Pestivirus APPV , was associated with the congenital tremor in piglets in North America and consequently in Europe and Asia. The present research aimed to describe the detection and characterization of APPV employing NS5B gene partial sequencing, gross pathology and histologic examination of piglets displaying congenital tremor from two different farms of Southern Brazil. No gross lesions were observed, and the histological findings revealed moderate vacuolization of the white matter of the cerebellum. Phylogenetic reconstruction reinforced the high genetic variability within the APPVs previously reported. This is the first report of APPV in South America suggesting that this new group of viruses may be widespread in swine herds in other countries as it is in Brazil. Characterisation of a pestivirus isolated from persistently infected mousedeer Tragulus javanicus. Mousedeer A, its The father of A probably had an acute infection resulting in antibodies to pestivirus and viral clearance. Sequence analysis and phylogenetic analysis revealed that the mousedeer The existences of persistently infected animals in non-domestic species have great implications for BVDV eradication campaigns in cattle Genotypes of Pestivirus RNA detected n anti influenza virus vaccines for human use. Samples were selected from manufacturers in Europe and the USA. Three samples of the nine vaccines tested These findings confirm previous reports, suggesting an improvement in preventive measures against contamination of biological products for human use. Phylogenetic and genomic characterization of a novel atypical porcine pestivirus in China. This genome sequence exhibited A need to define characteristics to be used in the taxonomy of the expanding pestivirus genus. The relatively high rate of genetic drift observed with pestiviruses results not only in the emergence of new species but also in heterogeneity within recognized species. The grouping of pestiviruses into species was first based on host and to a lesser extent on clinical presentation, then later by antigenic comparisons and more recently genetic comparisons. Subgrouping within species is a more recent taxonomic development and has been based primarily on genetic comparisons. While there are a number of publications proposing new species within the Pestivirus genus or new subgroups within recognized pestivirus species, there is no consensus on the criteria required to declare a new species and subgroup. Defining the criteria used for segregation of species and subgroups within a species is important because differentiating viral species and subspecies and determining the regions in which they are endemic has profound implications for eradication efforts, the design of vaccines and for regulation of trade in livestock and animal derived products, such as fetal bovine serum. This review outlines criteria used for differentiating species within the different genera of the Flaviviridae, compares criteria previously used for differentiating pestiviruses and discusses the need for the development of a unified system for defining species and subgroups within the Pestivirus genus. Epidemiology of Pestivirus infection in wild ungulates of the French South Alps. Inter-species transmission is often incriminated in the epidemiology of Pestivirus diseases. The purpose of this study was to investigate the prevalence of Pestivirus in some mountain wild ungulates and to determine their role in Pestivirus transmission, as mountain pastures are a place where cohabitations between wild and domestic ungulates are particularly high. Between and , a longitudinal epidemiological study was carried out on hunted ungulates in the French Hautes-Alpes department. In addition, mouflons Ovis gmelinii musimon were shown for the first time to be strongly infected These serological ELISA results were confirmed by comparative virus neutralization tests, performed on seven Pestivirus strains by using 15 seropositive samples. The highest antibody titers were directed against 2 BDV strains Av and 33s strains , rather than BDV-4, a strain responsible for Pyrenean-chamois epizooties. However, no Pestivirus RNA was detected by reverse-transcriptase polymerase chain reaction in serum and spleen samples from seronegative animals and no virus was isolated from those samples either. Efforts should be made to improve the protocol in order to be able to isolate and characterize the local strain. Finally, the oldness age and femaleness gender increase the risk of seroconversion in chamois. Pestiviruses infections at the wild and domestic ruminants interface in the French Southern Alps. In alpine pasture, interspecies transmission has recently been incriminated in the epidemiology of pestivirus infection. The aim of this study was to investigate pestivirus infections in wild and domestic ruminants sharing pastures in the French Southern Alps. Animal sera were screened for pestivirus antibodies against the pestivirus NS3 protein by a commercial blocking enzyme linked immunosorbent assay ELISA. All 38 domestic herds tested were positive for pestivirus -specific antibodies. Individual sero-prevalence reached For wild ruminants, Thus, an active circulation of pestiviruses was demonstrated in both wild and domestic ungulates from the French Southern Alps. The results suggest that interspecies transmission between sheep and chamois probably occur. Pestivirus strains exist as quasispecies swarms of individual viruses in infected animals and the viral populations making up t Identification and epidemiology of a rare HoBi-like pestivirus strain in Bangladesh. The genus pestivirus of the family flaviviridae consists of four recognized species: bovine viral diarrhoea virus 1 BVDV-1 , bovine viral diarrhoea virus 2 BVDV-2 , classical swine fever virus and border disease virus. Despite reports of serological evidence of BVDV in Bangladesh, the types of the virus circulating in cattle have not been identified. We conducted surveillance in cattle from May to August in three government veterinary hospitals to characterize BVDV in cattle of Bangladesh. The identification of this rare HoBi-like pestivirus or BVDV-3 strain in Bangladesh warrants further surveillance to evaluate its impact on livestock production. Seroprevalence and characterization of pestivirus infections in small ruminants and new world camelids in Switzerland. The seroprevalence of pestivirus infections in small ruminants and new world camelids in Switzerland was determined. In 5' sera of sheep from herds, sera of goats from 54 herds and sera of alpacas and lamas from 53 herds, population prevalences of Based on the ratio of respective antibody titres, In goats, the corresponding proportions were In Alpacas and Lamas, the source of infection of 1 animal was BDV-1 and that of 4 seropositive animals remained unresolved. In view of the phylogenetic relationship between pestiviruses , the unresolved source of infection is most probably attributable to other pestivirus genotypes circulating in small ruminants and new world camelids. Due to the predominance of pestiviral genotypes other than BVDV-1, the risk of transmission of BVDV from persistently infected small ruminants and new world camelids to cattle appears to be moderate, apart from close direct contact in mixed animal husbandry, communal pasturing and grazing in the Alps. Brefeldin A inhibits pestivirus release from infected cells, without affecting its assembly and infectivity. While considerable information has been gathered on virus entry into the host cell, genome structure and protein function, little is known about pestivirus morphogenesis and release from cells. Here, we analyzed the intracellular localization, N-glycan processing and secretion of BVDV using brefeldin A BFA , which blocks protein export from the endoplasmic reticulum ER and causes disruption of the Golgi complex with subsequent fusion of its cis and medial cisternae with the ER. BFA treatment of infected cells resulted in complete inhibition of BVDV secretion and increased co-localization of the envelope glycoproteins with the cis-Golgi marker GM Processing of the N-linked glycans was affected by BFA, however, virus assembly was not perturbed and intracellular virions were fully infectious, suggesting that trafficking beyond the cis-Golgi is not a prerequisite for pestivirus infectivity. Identification of a novel virus in pigs--Bungowannah virus: a possible new species of pestivirus. In an outbreak of sudden deaths occurred in week-old piglets on a farm in New South Wales, Australia. There was a marked increase in the birth of stillborn foetuses. Pathological changes consisted of a multifocal non-suppurative myocarditis. A viral infection was suspected but a wide range of known agents were excluded. A modified sequence independent single primer amplification SISPA method was used to identify a novel virus associated with this outbreak. Conserved 5'UTR motifs, the presence of a putative N pro coding region and limited antigenic cross-reactivity with other members of the Pestivirus genus, support the placement of this virus in the Pestivirus genus. Phylogenetic analysis of the 5'UTR, N pro and E2 coding regions showed this virus to be the most divergent pestivirus identified to date. Mucosal disease-like syndrome in a calf persistently infected by Hobi-like pestivirus. A calf persistently infected with Hobi-like pestivirus displayed severe clinical signs and subsequently died. Gross lesions and histopathological changes were suggestive of hemorrhagic and necrotic inflammation involving several tissues. A Hobi-like pestivirus pair was isolated from the dead calf, i. Two biotype-specific real-time reverse transcription-PCR assays determined the time of the emergence of the CP virus as 1 month before the calf's death. In contrast, great NCP virus loads were present in all tissues and biological fluids. The present report provides new insights into the pathogenesis and molecular mechanisms of this emerging group of pestiviruses. All Rights Reserved. Isolation and molecular characterisation of a pestivirus from goats in Egypt. Nine fetuses and neonates from sheep and goats in Egypt were screened for pestiviruses using immunohistochemistry IHC , virus isolation, and reverse transcription-polymerase chain reaction RT-PCR. Two goat kids with typical border disease BD were positive for pestivirus infection by immunohistochemistry IHC using polyclonal anti-BDV serum but not when four different monoclonal antibodies MAbs were used. To our knowledge, this is the first report of isolation of a pestivirus from goats in Egypt and is probably the second report worldwide of a goat kid showing central nervous signs associated with border disease. Complementation studies with the novel "Bungowannah" virus provide new insights in the compatibility of pestivirus proteins. Ayudas que ahora, y en determinados casos podrían llegar a sumarse a los ,48 euros mensuales fijados. Así, si lo hacen un día a la semana el pago es de 10 euros mensuales, si lo hacen dos días a la semana es de 20 euros mensuales En Suiza no hay una legislación que establezca una compensación para los trabajadores que realicen su función desde casa. Pero una reciente sentencia de un Tribunal Federal, recogida por RTS, ha obligado a una empresa a pagar a un trabajador al que obligó a teletrabajar , fijando una indemnización de francos suizos unos euros al mes. Por su parte, Alemania lleva trabajando en el desarrollo de su normativa sobre el teletrabajo desde abril, como anunció su ministro de Trabajo, Hubertus Heil, que quiere que los trabajadores puedan seguir trabajando a distancia tras la pandemia. Apenas existe legislación sobre este asunto. Laboral Escolar - Ver todos. Precios accesibles. Teléfono 62 , Celular WhatsApp y Celular Teléfono y WhatsApp RENTO departamento amueblado, camas matrimoniales, todo lo necesario, internet. Cerca del Seguro Social. Norte 52 entre 27 y 29 Poniente, Colonia 5 de Febrero. Independientes, semiamueblados. En Boulevard del Bosque. Etapa, Privada Chapultepec, amuebladas, internet, todos Manzana 22, casa 7. Informes los servicios incluidos. TV cable, hamacas, refrigerador, internet. Informes servicios. Celular y Remato metros. Calle Poniente entre 12 y 14 Norte, zona Centro. Se levanta escombro. Colinda con Vida Tapachula. Informes al la ciudad, a orilla de Carretera Mejor. Alguna MIEL en garrafas de 20 litros, Informes Nueva Alemania. Informes al luz y pozo. A orilla de calle, MANRRIK reparación aires acondicionados, refrigeradores, lavadoras, bombas para agua, instalaciones eléctricas, plomería, motores eléctricos, obra civil. Servicio a domicilio. Teléfono , , 62 Electricidad, plomería general. Técnico especialista. Instalaciones y reparaciones de bombas de agua, lavadoras, secadoras de ropa, estufas y boiler de agua y tinacos. Señor Isidro. Recibo carros a cambio. Comidas mexicanas, especialidad en piguas al gusto y variedad de mariscos. Atendido por su propietaria. Juan Alfredo Hidalgo Cabrera Ced. Gonzalo Egremy Rodas Cel. Domicilio: 6a. Calle Oriente No. Asesor Omar. Comunícate al Comunicarse al , Lavadoras, bombas, microondas, secadoras con gas. Técnico Roberto. Plomería, electricidad general. Todos son perros adultos y se entregan esterilizados, vacunados y desparasitados. Interesados hablar al y Teléfono en Avenida Palmas No. Laureles, Lic. Julia Renaud. Recétese un masaje, cuídese. Globoflexia, magia, equipo de sonido. Teléfono , 68 Nos adaptamos a su bolsillo. Avenida Norte entre 39 y 41 Poniente, Colonia 5 de Febrero. Avenida Central Sur No. Poniente, Tienda Coel, S. Requisitos: - Con experiencia - Solicitud de empleo requisitada - Estudios mínimos preparatoria - Dos cartas de recomendación - Comprobante de domicilio - Licencia de manejo vigente - INE - Acta de nacimiento - Constancia de no antecedentes penales Interesados comunicarse al Teléfono 62 ó al Celular , o acudir a entrevista en 3a. Avenida Norte No. Pago inmediato. GRAN promoción de motocicletas Italika. Contamos con gran Informes Precios especiales a flotillas. Lo ocuparía para hacer mis Teléfono , mandados. Sinceramente, en En Escuintla, a metros del Arco, salida Acapetahua. Fotos WhatsApp. Trato serio. Celular , , Y recuerda, los bienes son para solucionar los males. La Pontificia Universidad Católica de Chile ofrece este programa de 8 horas de duración que describe los principales componentes de la gestión de proyectos sin pérdidas lean project management. El contenido a revisar incluye los principios fundamentales de la filosofía de producción lean proveniente de la industria automotriz japonesa. Contabilidad para no contadores Este curso es para aquellos que busquen aprender los fundamentos. En estos días de cuarentena causada por la pandemia del coronavirus Covid, cualquier persona puede, a través de internet, capacitarse y especializarse en un sinfín de temas. Los intereses varían de país en país. Camino a la Excelencia en Gestión de Proyectos. Lo ofrece la Universidad Nacional Autónoma de México con una duración aproximada de 11 horas. Finanzas personales Este curso tiene una duración aproximada de cinco horas. Lo ofrece la Universidad Nacional Autónoma de México y pretende enseñar a los estudiantes cómo mejorar su planeación financiera personal. Aprender El proceso de aprendizaje, aunque distinto para cada persona, se puede mejorar. Lo ofrece la UNAM y tiene una duración aproximada de 47 horas. Robótica Este curso es el indicado para aquellos que quieren aprender a armar un robot y controlarlo con su teléfono móvil. El curso tiene una duración aproximada de 9 horas y lo ofrece la UNAM. Tiene una duración aproximada de seis meses y lo recomendable es estudiar dos horas a la semana. El curso, también lo puede tomar quien esté interesado en prepararse para ocupar puestos en niveles gerenciales..

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Sexy tips Watch Porn Movies Xxx Ziekenhuis. Molecular identification of a new pestivirus associated with increased mortality in the Pyrenean Chamois Rupicapra pyrenaica pyrenaica in Spain. Pestivirus infection was identified in 16 of 17 chamois during an outbreak of a previously unreported disease in Pyrenean chamois Rupicapra pyrenaica pyrenaica in northeastern Spain in By analysis of the 5' noncoding regions of the virus, we assigned it to the border disease virus cluster with pairwise similarity values ranging from It will be important to investigate the association of this pestivirus with disease in Pyrenean chamois. Seroprevalence of pestivirus in four species of alpine wild ungulates in the High Valley of Susa, Italy. Wildlife, once infected, can serve as a reservoir of infectious diseases that form a constant threat to domestic livestock. To make control and eradication programs successful in the long-term, presence of pestivirus in wildlife populations should be monitored. The goal of this study was to investigate seroprevalence of pestivirus in four alpine wild ungulates in the High Valley of Susa, north-west Italy. Species studied were: red deer Cervus elaphus , roe deer Capreolus capreolus , wild boar Sus scrofa and chamois Rupicapra rupicapra. A further goal was using virus neutralisation tests VNT for four strains of pestivirus in chamois and wild boar. Three hundred and seventy-five serum samples collected during the hunting season of were tested for pestivirus specific antibodies. Positive sera of chamois and wild boar were subsequently tested in a VNT with four major subtypes of pestivirus , and virus isolation was performed. No antibodies were found in the 73 samples of roe deer, while 7 Several possibilities, which might explain the high seroprevalence in chamois are discussed. Pestivirus antibodies were found in three out of four large alpine ungulates in the High Valley of Susa. Seroprevalence was particularly high in chamois. Further investigation is needed to characterise the pestiviruses that circulate in these animals. A multiplex RT-PCR assay for the rapid and differential diagnosis of classical swine fever and other pestivirus infections. Classical swine fever is a highly contagious viral disease causing severe economic losses in pig production almost worldwide. All pestivirus species can infect pigs, therefore accurate and rapid pestivirus detection and differentiation is of great importance to assure control measures in swine farming. Here we describe the development and evaluation of a novel multiplex, highly sensitive and specific RT-PCR for the simultaneous detection and rapid differentiation between CSFV and other pestivirus infections in swine. The universal and differential detection was based on primers designed to amplify a fragment of the 5' non-coding genome region for the detection of pestiviruses and a fragment of the NS5B gene for the detection of classical swine fever virus. The assay proved to be specific when different pestivirus strains from swine and ruminants were evaluated. The analytical sensitivity was estimated to be as little as 0. The assay analysis of 30 tissue homogenate samples from naturally infected and non-CSF infected animals and 40 standard serum samples evaluated as part of two European Inter-laboratory Comparison Tests conducted by the European Community Reference Laboratory, Hanover, Germany proved that the multiplex RT-PCR method provides a rapid, highly sensitive, and cost-effective laboratory diagnosis for classical swine fever and other pestivirus infections in swine. Experimental inoculation of calves with atypical Hobi-like pestivirus shows pattern similar to BVDV The experiment The pathogenesis of the infection with Hobi-like viruses has not yet been fully elucidated. The purpose of our study was to investigate the course Concurrent peste des petits ruminants virus and pestivirus infection in stillborn twin lambs. Concurrent infection with peste des petits ruminants virus PPRV and pestivirus was diagnosed in stillborn twin lambs. Macroscopic anomalies that were typical of border disease included scoliosis, brachygnathism, prognathism, arthrogryposis, hydranencephaly, cerebellar hypoplasia, and hairy fleece; pestiviral antigen was detected by IHC in the brain, liver, lungs, and kidneys. To the authors' knowledge, PPR has not been reported previously as a congenital infection or in combination with pestiviral infection. Genome analysis of an atypical bovine pestivirus from fetal bovine serum. Alignment of the complete nucleotide sequence and phylogenetic analysis indicate that this viral isolate belongs to atypical pestiviruses. Sequence-based comparative study of classical swine fever virus genogroup 2. This study was undertaken with the aim to compare and establish the genetic relatedness between classical swine fever virus CSFV genogroup 2. The complete genome sequence, complete open reading frame, 5' and 3' non-coding region NCR sequences were analyzed and compared with reference pestiviruses strains. Clustal W model in MegAlign program of Lasergene 6. Phylogenetic analysis was carried out using MEGA 6. Sequence homology of 5' and 3' NCRs was found to be In phylogenetic analysis, overall tree topology was found similar irrespective of sequences used in this study; however, whole genome phylogeny of pestivirus formed two main clusters, which further distinguished into the monophyletic clade of each pestivirus species. Integrando empresas e cooperativas de catadores em fluxos reversos de resíduos sólidos pós-consumo: o caso Vira-Lata. Esta pesquisa analisa os desafios e as perspectivas para o desenvolvimento dessas iniciativas. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Pestiviruses are economically important pathogens of livestock. The aim of this study was to determine the scope of antiviral activity of DB among diverse pestiviruses. Cytotoxicity of the compound was assayed for each cell type. In two of three tests, a concentration of 0. Bungowannah virus was completely inhibited at a concentration of 0. As cytotoxicity is not evident at these concentrations, this antiviral compound potentially represents an effective preventative or therapeutic for diverse pestiviruses. Full Text Available Enveloped viruses have developed various adroit mechanisms to invade their host cells. This process requires one or more viral envelope glycoprotein to achieve cell attachment and membrane fusion. Members of the Flaviviridae such as flaviviruses possess only one envelope glycoprotein, E, whereas pestiviruses and hepacivirus encode two glycoproteins, E1 and E2. Although E2 is involved in cell attachment, it has been unclear which protein is responsible for membrane fusion. We report the crystal structures of the homodimeric glycoprotein E2 from the pestivirus bovine viral diarrhea virus 1 BVDV1 at both neutral and low pH. Our results suggest that the pestivirus and possibly the hepacivirus fusion machinery are unlike any previously observed. Presence of atypical porcine pestivirus APPV genomes in newborn piglets correlates with congenital tremor. Pestiviruses are highly variable RNA viruses belonging to the continuously growing family Flaviviridae. Here, a screening of sera from apparently healthy adult pigs demonstrated the existence of APPV in Germany with an estimated individual prevalence of 2. Additionally, APPV genomes were detected in newborn piglets affected by congenital tremor CT , but genomes were absent in unaffected piglets. High loads of genomes were identified in glandular epithelial cells, follicular centers of lymphoid organs, the inner granular cell layer of the cerebellum, as well as in the trigeminal and spinal ganglia. Retrospective analysis of cerebellum samples from demonstrated that APPV can be found in piglets with CT of unsolved aetiology. APPV sequences derived from different regions in Germany demonstrated to be highly variable. Taken together, the results of this study strongly suggest that the presence of APPV genomes in newborn piglets correlates with CT, while no association with clinical disease could be observed in viremic adult pigs. Pestivirus in alpine wild ruminants and sympatric livestock from the Cantabrian Mountains, Spain. Results showed a higher seroprevalence in cattle Conversely to other similar grazing systems, sheep flocks did not play a relevant role in the pestivirus epidemiology in this region. Pestivirus infections in wild ruminants were sporadic and most probably dependent on a domestic source. This study describes the use of a novel and rapid long reverse transcription RT -PCR for the generation of infectious full-length cDNA of pestiviruses. Infectious virus was obtained after one cell culture passage. The rescued viruses had a phenotype similar to the parental Border Disease virus strain. Summary Enveloped viruses have developed various adroit mechanisms to invade their host cells. Experimental infection of cattle, sheep and pigs with 'Hobi'-like pestivirus. To date, limited information is available on the ability of 'Hobi'-like pestiviruses putative bovine viral diarrhoea 3 to infect and cause disease in animal species traditionally affected by pestiviruses. Appearance of clinical signs, leukopenia, viremia, viral shedding and seroconversion were monitored for 28 days post-infection. Calves and lambs were successfully infected, displaying respiratory signs nasal discharge , moderate hyperthermia and leukopenia, viremia and viral shedding through the nasal and faecal routes. In contrast, inoculated piglets did not display any clinical signs nor leukopenia and viral RNA was not detected in any biological samples. Nevertheless, the presence of detectable antibodies by virus neutralisation accounted for a successful, albeit limited infection of these animals. A structural model of pestivirus E rns based on disulfide bond connectivity and homology modeling reveals an extremely rare vicinal disulfide. Erns is a pestivirus envelope glycoprotein and is the only known viral surface protein with RNase activity. Erns is a disulfide-linked homodimer of kDa; it is found on the surface of pestivirus -infected cells and is secreted into the medium. In this study, the disulfide arrangement of the nine. The strategy applied in this study is useful for classifying novel pestiviruses in the future. Natural infection of cattle with an atypical 'HoBi'-like pestivirus --implications for BVD control and for the safety of biological products. The results from virus neutralisation tests performed on sera collected from cattle in the herd of the infected calf, showed that these cattle had markedly higher antibody titres against the atypical pestivirus 'HoBi' than against Bovine Viral Diarrhoea Virus types 1 and 2, or Border Disease Virus. The results also supported, consequently, the results from the molecular analysis, and demonstrated that a 'HoBi'-like pestivirus had been introduced to, and was now circulating in the herd. This study is the first to report a natural infection in cattle with a virus related to this atypical pestivirus , and it suggests that this group of pestiviruses may already be spread in cattle populations. The findings have implications for BVD control and for the biosafety of vaccines and other biological products produced with foetal calf serum. Consequently, these atypical pestiviruses should be included in serological assays, and any diagnostic assay aimed at detection of pestiviruses in biological products or animals should be tested for its ability to detect them. Congenital tremors is a sporadic disease of neonatal pigs characterized by action-related repetitive myoclonus. A majority of outbreaks of congenital tremors have been attributed to an unidentified virus. The objectives of this project were to 1 detect potential pathogen s in samples from piglets with congenital tremors and 2 develop an infection model to reproduce disease. Using next-generation sequencing, a divergent lineage pestivirus was detected in piglets with congenital tremors. The virus was originally most closely related to a bat pestivirus but is now more closely related to a recently published novel porcine pestivirus provisionally named atypical porcine pestivirus. A quantitative real-time PCR detected the virus in samples from neonatal piglets with congenital tremors from two separate farms, but not in samples from unaffected piglets from the same farm. To fulfill the second objective, pregnant sows were inoculated with either serum containing the pestivirus or PBS control by intravenous and intranasal routes simultaneously with direct inoculation of fetal amniotic vesicles by ultrasound-guided surgical technique. Inoculations were performed at either 45 or 62 days of gestation. All sows inoculated with the novel pestivirus farrowed piglets affected with congenital tremors while PBS-inoculated control piglets were unaffected. Tremor severity for each piglet was scored from videos taken 0, 1 and 2 days post-farrowing. Tremor severity remained relatively constant from 0 to 2 days post-farrowing for a majority of piglets. The virus was consistently detected by PCR in tissues from piglets with congenital tremors but was not detected in control piglets. Full Text Available Congenital tremors is a sporadic disease of neonatal pigs characterized by action-related repetitive myoclonus. Detection and genetic identification of pestiviruses in Brazilian lots of fetal bovine serum collected from to Thirty-nine lots Six lots 8. Four FBS batches 5. Five batches 6. The high frequency of contamination of FBS with pestivirus RNA reinforce the need for systematic and updated guidelines for monitoring this product to reduce the risk of contamination of biologicals and introduction of contaminating agents into free areas. Recombinant pestivirus E2 glycoproteins prevent viral attachment to permissive and non permissive cells with different efficiency. Bovine viral diarrhoea virus BVDV is an economically important animal pathogen, which like other pestiviruses has similar molecular biological features to hepaciviruses, including human Hepatitis C virus. The pestivirus E2 glycoproteins are the major target for virus-neutralising antibodies, as well as playing a role in receptor binding and host range restriction. In this study, recombinant E2 glycoproteins rE2 derived from three different pestivirus species were examined for their inhibitory effects on pestivirus infectivity in cell culture. The ability of rE2 glycoprotein to inhibit the infection of permissive cells by both homologous and heterologous virus was compared, revealing that the inhibitory effects of rE2 glycoproteins correlated with the predicted similarity of the E2 structures in the recombinant protein and the test virus. This result suggests that the sequence and structure of E2 are likely to be involved in the host specificity of pestiviruses at their point of uptake into cells. Genomic and antigenic relationships between two 'HoBi'-like strains and other members of the Pestivirus genus. To date, few complete genome sequences of 'HoBi'-like viruses are available in public databases. Moreover, detailed analyses of such genomes are still scarce. In an attempt to expand data on the genetic diversity and biology of pestiviruses , two genomes of 'HoBi'-like viruses recovered from Brazilian cattle were described and characterized in this study. Analysis of the whole genome and antigenic properties of these two new 'HoBi'-like isolates suggest that these viruses are genetically close to recognized pestiviruses. The present data provide evidence that 'HoBi'-like viruses are members of the genus Pestivirus and should be formally recognized as a novel species. The viral envelope is not sufficient to transfer the unique broad cell tropism of Bungowannah virus to a related pestivirus. Bungowannah virus is the most divergent pestivirus , and both origin and reservoir host have not been identified so far. We therefore performed in vitro tropism studies, which showed that Bungowannah virus differs remarkably from other pestiviruses. Interestingly, cell lines of vervet monkey, mouse, human and even of bat origin were susceptible. This broad in vitro tropism was not observed for a chimeric bovine viral diarrhoea virus BVDV expressing all structural proteins of Bungowannah virus. The viral envelope was not sufficient to completely transfer the cell tropism of Bungowannah virus to another pestivirus , and viral RNA replication was either markedly reduced or not detectable in a number of different cell lines for the tested BVDV strain and the chimera. We therefore suggest that the replication machinery together with the viral envelope is responsible for the unique broad cell tropism of Bungowannah virus. Numerical taxonomy of the genus Pestivirus : new software for genotyping based on the palindromic nucleotide substitutions method. Pestivirus identification using PNS was evaluated on five hundred and forty-three sequences at genus, species and genotype level using this software. The software is freely available at www. A serosurvey for ruminant pestivirus exposure conducted using cattle sera collected for brucellosis surveillance in the United States. Four species of ruminant pestivirus are currently circulating in the United States: Bovine viral diarrhea virus 1 and 2 BVDV-1, -2; predominant host: cattle , Border disease virus BDV; predominant host: sheep , and pronghorn virus sporadically detected in wild ruminants. A third bovine pestivirus called HoBi-like virus has been detected in cattle and water buffalo in South America, Asia, and Europe. To date, no isolations of HoBi-like viruses from U. To assess exposure, 2, cattle sera, collected between and as part of the U. In addition, RNA was extracted and tested by reverse transcription-polymerase chain reaction for the presence of pestiviruses ; all samples tested negative. The percent of VN-positive samples was Because the 3 bovine pestiviruses are antigenically cross-reactive, the comparative level of antibody against each pestivirus species was determined. Based on comparative titers, samples were segregated into 6 categories: no titers 7. X-ray structure of the pestivirus NS3 helicase and its conformation in solution. Pestiviruses form a genus in the Flaviviridae family of small enveloped viruses with a positive-sense single-stranded RNA genome. Viral replication in this family requires the activity of a superfamily 2 RNA helicase contained in the C-terminal domain of nonstructural protein 3 NS3. The structure deviates significantly from that of NS3 of other genera in the Flaviviridae family in D3, as it contains two important insertions that result in a narrower nucleic acid binding groove. We also show that mutations in pNS3h that rescue viruses from which the core protein is deleted map to D3, suggesting that this domain may be involved in interactions that facilitate particle assembly. Finally, structural comparisons of the enzyme in different crystalline environments, together with the findings of small-angle X-ray-scattering studies in solution, show that D2 is mobile with respect to the rest of the enzyme, oscillating between closed and open conformations. Binding of a nonhydrolyzable ATP analog locks pNS3h in a conformation that is more compact than the closest apo-form in our crystals. Together, our results provide new insight and bring up new questions about pNS3h function during pestivirus replication. Although pestivirus infections impose an important toll on the livestock industry worldwide, little information is available about the nonstructural proteins essential for viral replication, such as the NS3 helicase. SUN Otros 4. Consulta lunes a viernes p. El ritmo de solicitudes motivadas en la pandemia de COVID, sin embargo, ha bajado, respecto a los 5. Aproximadamente uno de cada seis trabajadores estadounidenses ha perdido su empleo desde mediados de marzo, lo que constituye la peor serie de despidos registrada. ARIES 21 marzo abril. Lo quisieron compartir con sus. LEO 23 julio agosto. No permitas que los malos entendidos enfríen las relaciones con tu pareja, pues lo que no se aclara hiere. 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Roberto Banchik, director general de Penguin Random House México, asegura que van un poco como los alcohólicos, día con día, porque todo puede cambiar; dice que hasta febrero hacían proyecciones a meses e incluso a un año o dos, pero esta pandemia ha cambiado todo. Algunas opciones Esa es la preocupación del gremio de editores y de libreros en general. El terremoto que hace unos meses azotó a los Astros de Houston por robo de señales en la temporada tuvo este miércoles una réplica de menor intensidad, pero en Boston. Las Grandes Ligas dieron a conocer que culminó la investigación a los Red Sox por incurrir en dicha acción espionaje , aunque llevada a cabo de modo distinto, durante la campaña , en la que resultaron campeones. Mediante un comunicado, el comisionado Rob Manfred detalló que las medidas adoptadas por Watkins no tuvieron el mismo impacto que las llevadas a cabo por el equipo de Houston un año antes. Necesitaba fortificar a los futbolistas mexicanos y Hugo ya era una figura internacional. En ese tiempo, Hugo dijo abiertamente que no volvería a la Selección, hasta que Maurer e Ibarra dejaran la Federación Mexicana de Futbol. Hace muchísimos años México no lo era, y hoy compite con muy buenos jugadores. Los participantes, que se conforman con sólo participar; los protagonistas y los candidatos. De acuerdo con medios locales, los directivos del balompié ibérico han analizado que el mejor panorama es que el resto de la temporada y la mitad de la que viene se dispute a puerta cerrada en los estadios. Lo que ya se piensa es en el retorno de los entrenamientos. Ya me pasó la edad, me pasó esa presión. El mal paso por los Diablos Rojos le hizo reflexionar que su tiempo en los banquillos se terminó. En su trayectoria conquistó un título de Liga, con el Atlante en la temporada Al Ascenso MX ya no hay quien lo salve. Al nuevo experimento del futbol mexicano, hasta el momento conocido como Liga de Expansión, le falta mucho por desarrollar, sobre todo cinco puntos para consolidar sus bases. Sin olvidar que es posible que algunos de los 12 clubes del extinto Ascenso MX puedan dar un paso al costado. En caso de que se implemente para menores de 23 años de edad, jugadores no cumplen con la restricción y se quedarían sin cupo en la Liga de Expansión. Bonilla tiene en mente consolidar una fuente estable de ingresos, como los derechos televisivos, por lo que conquistar a empresas para transmitir los partidos, a nivel regional y nacional, es prioridad. Diversos directivos argumentaron que la crisis económica en el Ascenso MX fue la principal razón para crear este formato, sin opción a Primera División. Constatando esta entrega estuvieron los representantes de Gobierno del Estado de Chiapas, por parte de la Delegación Regional de Protección Civil estuvo Julisa Briones; el delegado de Gobierno en la región, Efraín García Ordóñez, quien invitó a los representantes de ambas dependencias municipales a darle buen uso a las unidades, y hablando en. El Presidente Municipal estuvo acompañado de su Cabildo así como de Moisés Villarreal Hurtado, secretario de Protección Civil Municipal, y del tesorero municipal, Luis Vicente Justiniano Wong, quien comentó que gracias al apoyo y planeación del Cabildo se pudo obtener recursos para la compra de las unidades. De acuerdo al Servicio. Sismológico Nacional SSN , el epicentro se ubicó a kilómetros al suroeste de Ciudad Hidalgo, en el municipio de Suchiate, segundos después de las horas. En los primeros 23 días de Abril, Chiapas ha sido escenario de temblores, mientras que en al año se han contabilizado mil , es decir, un promedio cercano a los diez diarios. Por lo mismo, la Comisión Nacional del Agua Conagua hizo un estudio técnico y concluyó que la red, ubicada en la prolongación de la 17 Oriente, debería reconstruirse, pero evitando el afluente. Los recursos que se requerían para corregir la obra fueron autorizados por el Gobierno Federal y ya se iniciaron los trabajos. La autorización de la obra que hizo la Conagua y las acciones que lleva a cabo,. De acuerdo a la opinión de Martínez López, si se continuaba dejando la red en el mismo lecho del río se iba a seguir contaminando y corría el riesgo de dañarse por alguna inundación. Así también, que la mejor alternativa, a criterio de la Conagua, fue pasarla por arriba de la banqueta y cubrir la. Esa técnica ya se ha hecho en otros puntos de la ciudad, en. Se desconoce si. En entrevista para EL ORBE, reconoció la importancia del transporte colectivo por la necesidad que tienen de trasladarse desde sus comunidades hacia cualquier punto del municipio y viceversa, sobre todo para realizar la compra de alimentos y medicinas, o para ir al trabajo. Cabe señalar que en el documento se incluyen nueve. Durante una reunión virtual de la mesa técnica, la diputada Barrera Badillo destacó la importancia de que los legisladores revisen la propuesta de dictamen y emitan sus consideraciones, para procesarlas y se apruebe, una vez que se reanuden las actividades presenciales. También, la mesa técnica. Comunicado de Prensa. En entrevista exclusiva para EL ORBE reveló que tienen conocimiento de que hay muchos migrante infectados en Estados Unidos, tanto libres como asegurados en centros de detención. Ahí hay al menos 20 migrantes detenidos que han dado positivo a la pandemia, pero que lo. En esa misma ciudad hay otras 15 persona que ya dieron positivo, pero no se sabe como fue el mecanismo de contagio y si tuvieron algo que ver los migrantes. En el caso de Tapachula, indicó que tuvieron conocimiento de un migrante retenido en la Estación Migratoria Siglo XXI y que, por lo mismo, solicitaron informes al Instituto Nacional de Migración INM , pero que no les quisieron dar respuestas. Entrevistado a un costado de la alcaldía, indicó que los migrantes se sienten protegidos por los convenios que ha hecho el gobierno federal mexicano con la Organización de las Naciones Unidas ONU de abrir las puertas del país y hasta mantenerlos con subsidios económicos. Hasta ayer 23 de Abril, se reportaron en Italia , casos de infectados, 25, de muertos y 57, recuperados. Asimismo, se informó de nuevos pacientes recuperados. Italia se encuentra en el puesto 3 de países con mayor cantidad de infectados. De las , personas actualmente positivas, 81, se encuentran en aislamiento domiciliario, 22, internadas con síntomas y en terapia intensiva. En entrevista, Ramírez Leal comentó que en la construcción del Aeropuerto Internacional de Santa Lucía hay una gran oportunidad de emplear a trabajadores de constructoras formales que pagan impuestos. Pero las constructoras han sido desplazadas de. Ramírez Leal dijo que las constructoras han sido estigmatizadas debido a que algunas empresas nacionales y extranjeras abusaron en sexenios pasados, por lo que dejaron hospitales y carreteras a medias, o como en el Tren. En este marco, Llaven Abarca señaló que la asociación ciudadana de manera imparcial y transparente en su reporte correspondiente a los meses de Enero, Febrero y Marzo, informó que Chiapas junto con Baja California Sur y Sinaloa fueron los Estados mejores evaluados por el índice de sus indicadores delictivos. Diabetes, hipertensión, obesidad y tabaquismo son las enfermedades que. Veracruz, Sinaloa y Nayarit son Estados con un panorama similar. Reconocemos en la prevención la vía para evitar la muerte y la desolación. Se precisa unidad para afrontar los desafíos económicos. En los tres, la hipertensión es el mayor riesgo para los pacientes. Reiteró que la extensión de la Jornada Nacional de Sana Distancia hasta finales de Mayo, tiene como objetivo reducir en mayor medida la afectación a la población, por ello es fundamental que la sociedad colabore y de esa manera no saturar los servicios de salud. Comentó que sumado a la convocatoria de permanecer en el hogar, es fundamental organizarse con los integrantes de la familia para que sea un solo miembro el que salga a realizar la compra de alimentos, medicinas y productos de primera necesidad, pero tomando todas las medidas de protección. M éxico. La mitad de estas personas -unas mil- acudiría a atención médica y alrededor de 10 mil requerirían terapia intensiva. Expuso que Locatel, a través de los mensajes SMS, ha atendido mil cuestionarios completados; de estos, 3 mil se han reconocido como sospechoso y este miércoles hubo traslados; 41 de Cruz Roja, 81 del ERUM, cuatro de ambulancias particulares, dos de las alcaldías y ocho de la Secretaría de Salud. Viernes 24 de Abril de De la intensa conferencia matutina de antier miércoles 22 y en lo referido a la crítica a la prensa crítica, valdría el esfuerzo histórico para hacer unas precisiones referidas a caracterizaciones de periodistas buenos y periodistas malos. En este sentido, con la compra del operador de cable, Vodafone, que se encuentra inmersa en el despliegue de una red de fibra conjunta con Orange, aumentaría de forma inmediata su alcance en el mercado fijo en España. Vodafone cuenta actualmente con cerca de 14 millones de clientes de telefonía móvil y unos NEI VFQ data from 50 patients with low vision were analyzed using the standard method of summing Likert-type scores and calculating an overall average, Rasch analysis using Winsteps software, and the Massof algorithm in Excel. Correlations between scores were calculated. Rasch person separation reliability and other indicators were calculated to determine the validity of the subscales and of the 7-item instrument. Scores calculated using all three methods were highly correlated, but evidence of floor and ceiling effects was found with the standard scoring method. None of the subscales investigated proved valid. The 7-item instrument showed acceptable person separation reliability and good targeting and item performance. Although standard scores and Rasch scores are highly correlated, Rasch analysis has the advantages of eliminating floor and ceiling effects and producing interval-scaled data. The Massof algorithm for approximation of the Rasch person measure performed well in this group of low-vision patients. The validity of the subscales VFQ should be reconsidered. Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle. We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine-amide NEI concentrations in discrete brain areas in male rats. To investigate the possible effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone LH , estradiol and progesterone concentrations were measured in control, hypothyroid hypoT, treated with PTU during days and hyperthyroid hyperT, l-T4 during days animals. Both treatments blunted the LH surge. Hypo- and hyperthyroidism increased estradiol concentrations during proestrus afternoon P-PM , although hypoT rats showed lower values compared to control during proestrus morning P-AM. NEI concentrations were lower in hypoT rats during the estrous cycle except in estrus E in the peduncular part of the lateral hypothalamus PLH. The present results indicate that NEI concentration is regulated in a complex manner by hypo- and hyperthyroidism in the different areas studied, suggesting a correlation between NEI values and the variations of gonadal steroid levels during estrous cycle. These changes could be, in part, responsible for the alterations observed in the hypothalamic-pituitary-gonadal axis in these pathologies. Prostatic biopsy in the prostate specific antigen gray zone; La biopsia prostatica multipla nalla zona grigia dei valori dell'antigene prostatico specifico. Drudi, F. La Sapienza, Rome Italy. Of the patients who gave full informed consent, 34 people were selected whose age range was between 56 to 76 years mean: PSA velocity was calculated collecting 3 blood samples every 30 days for 2 months. Our findings confirm that prostatic biopsy can detect tumors also in areas which appear normal at transrectal US and digital examination, and that PSA rate increases in patients with positive histology. Finally, the actual clinical role of prostatic biopsy relative to all other diagnostic imaging techniques remains to be defined. Di questi sono stati selezionati eta' tra 56 e 76 anni, eta' media 64 anni. Energy and telecommunications public services; Servizi pubblici nei settori dell'energia e delle telecomunicazioni. Salini, M. The aim of this work is the evolution of the energy and telecommunication public services. The article runs through the main stages in the public services' history and shows how open market rules may cause the future dissolution of public service notion. The conclusion wishes the hastening of public services privatisation and a Corporate Governance reform as a mean to pursue general interest. Se ne ripercorrono le principali tappe storiche e si evidenzia come le regole di apertura dei mercati possano causare la dissoluzione del concetto di servizio pubblico. Le conclusioni sottolineano la necessita' di accelerare la privatizzazione dei servizi pubblici e la riforma della Corporate Governance come strumento per il raggiungimento dell'interesse generale. The role of 3D Helical CT in the reconstructive treatment of maxillofacial cancers; Tomografia Computerizzata spirale con elaborazioni tridimensionali di superficie nel trattamento ricostruttivo dei tumori maligni del massiccio facciale. De Rosa, V. Nazionale Tumori Fondazione G. Pascale, Naples Italy ; Parascandolo, S. Further Ti features are strength, biocompatibility and easy handling. The prospect is provided to identify virtual 3D presurgical ablation planes. These may allow the surgeon to improve plastic reconstruction and shorten intervention time. Sono state eseguite dal al 11 ricostruzioni plastiche dell'osso mascellare per neoplasie osteodestruenti il massiccio facciale utilizzando materiale alloplastico. Applicato nel cavo residuo dell'osso un otturatore siliconato sormontante una protesi acrilica con arcata dentaria per la ricostruzione del palato. In due casi utilizzato pericardio bovino modulato sulla soluzione di continuo. Tutti i pazienti sono stati studiati con TC spirale sia nella fase preoperatoria che entro il sesto mese dall'intervento chirurgico. L'elaborazione tridimensionale della superificie sui dati ottenuti con acquisizione volumetrica ha fornito in tutti casi la fedele. Usual interstitial pneumonitis UIP presenting with Wells grade 3. Can imaging methods help predict further progression of disease? Fasano, L. Servizio di Medicina Nucleare; Battista, G. Three different grades of idiopathic pulmonary fibrosis can be identified by HRCT pattern. Patients with predominant ground-glass opacity grade 1 usually improve after treatment and may have a better prognosis. The subjects with a predominant reticular pattern and honeycombing grade 3. Nevertheless, these patients may worsen even in the absence of HRCT features of the so-called alveolitis. The aim of this report is to investigate the predictive role of some noninvasive imaging methods HRCT with visual score of disease extent; Gallium scintigraphy; DTPA scintigraphy in patients with idiopathic fibrosis and a prevalent macroscopic fibrosis at HRCT study. La fibrosi irreversibile tuttavia non e' necessariamente una situazione stabile ma puo progredire ed evolvere ulteriormente. In particolare i pazienti che gia all'esordio presentano solo i segni della fibrosi possono peggiorare a distanza di tempo nonostante la terapia. Scopo del lavoro e' stato quello di individuare in un gruppo di pazienti con prevalente fibrosi macroscopica quale possa essere un parametro preditivo della successiva evoluzione della malattia. Abdominal adipose tissue distribution in obese children. US versus CT measurements; Valutazione della distribuzione del tessuto adiposo addominale nei bambini obesi. Confronto tra ecografia e Tomografia Computerizzata. Ferrozzi, F. Clinica Pediatrica; Campani, R. Con l'ecografia sono state valutate le distanze tra il muscolo retto e la colonna vertebrale e tra il muscolo retto e l'aorta, senza e con compressione dosata, quali parametri indicativi dello spessore del grasso viscerale nonche' la distanza tra cute e muscolo retto quale indicatore del grasso sottocutaneo. I risultati dell'ecografia e della TC sono stati inoltre correlati con altre variabili morfometriche peso, peso corporeo ideale, plicometria cutanea. Non e' stata riscontrata alcuna correlazione tra l'indice di massa corporea e i dati ecografici e TC. I risultati ottenuti suggeriscono che l'ecografia puo' essere utilizzata in alternativa alla TC nella valutazione della distribuzione del grasso corporeo nei bambini obesi. Full Text Available Abstract Background The use of self-report questionnaires to substitute for visual acuity measurement has been limited. We examined the association between visual impairment and self reported visual function in a population sample of older people in the UK. Methods Cross sectional study of people aged more than 75 years who initially participated in a trial of health screening. After adjustment for age, gender, practice and NEI -VFQ sub-scale scores, those complaining of poor vision in general were 4. Self-reported limitations with social functioning and dependency on others due to poor vision were also associated with visual impairment odds ratios, 2. Those reporting difficulties with near vision and colour vision were more likely to be visually impaired odds ratios, 2. Although differences in NEI -VFQ scores were small, scores were strongly associated with visual acuity, binocular status, and difference in acuity between eyes. Conclusion NEI -VFQ questions regarding the quality of general vision, social functioning, visual dependency, near vision and colour vision are strongly and independently associated with an objective measure of visual impairment in an. Conversazioni autobiografiche con Albino Sacco-Casamassima. Olivetti venne a Matera con un certo ambasciatore americano che praticamente aveva preparato o stava dando una mano per il piano Marschall, venne a Matera e mi vollero incontrare. Io sono stato chiamato dalla piazza, stavo nella piazza, era il mese di luglio, una cosa di questo genere, e andai in un bar, un bar ad angolo mi ricordo in Via Don Minzioni, dove questo Olivetti mi disse 'ma lei che cosa fa coi sassi? Vision-related quality of life assessment using the NEI -VFQ in adolescents and young adults with a history of congenital cataract. Tra classicità ed emozione romantica", Tra classicità ed emozione romantica", Scicli, Edizioni di storia e studi sociali, [Book Review. Suburban amoebiasis. CT and US findings and percutaneous treatment of amoebic liver abscess; Amebiasi sub-urbana: aspetti diagnostici con tomografia computerizzata ed ecografia e trattamento percutaneo degli ascessi amebici del fegato. Servizio di Radiologia; Rossi, E. Servizio di Radiologia; Capuano, N. The study reports ultrasonography and computerise tomography findings in 16 patients with amoebic abscesses, 12 of whom lived in a temperate peripheral area north-east of Naples Italy. All patients have a clinical-diagnostic condition called sub-urban amoebiasis. The personal experience with the US guided therapeutic drainage of amoebic abscess with repeated cavity washing, which is important for positive parasitology. Combined US and CT assessment facilitated the diagnosis of amoebiasis and its differentiation from pyogenic abscess and hepatoma. Diversi studi confermano che la terapia medica dell'amebiasi risulta piu' efficace quando viene associato il drenaggio percutaneo degli ascessi epatici con piu' rapida guarigione clinica e risposta favorevole dell'organismo. Scopo del presente lavoro e' di descrivere gli aspetti ecografici e di tomografia computerizzata degli ascessi amebici in un gruppo di 16 pazienti , 12 dei quali residenti in zona temperata e periferica di una vasta area a nord-est di Napoli presentandosi con caratteristico e raro quadro clinico-diagnostico definito amebiasi sub-urbana. Si discute infine l'esperienza personale del drenaggio terapeutico sotto guida ecografica dell'ascesso con tecnica del lavaggio ripetuto dalla cavita', importante ai fini della positivita' dell'esame. L'associazione dei reperti tipici ecografici e TC ha consentito la diagnosi agevole dell'amebiasi differenziandola dall'ascesso piogenico e dall'epatoma. Scrittura e militanza: due stagioni di donne cattoliche nei Paesi Bassi Spagnoli secc. Donne attive in quanto militanti cattoliche. These women were catholic militants. The analysis is based on printed and unprinted female texts, according to their context of production the Erasmian humanism and the catholic and Spanish reconquest. Pratiche di Social Networking: una prima sperimentazione nei corsi di italiano L2 per studenti Erasmus. Yang, Joon Eon; Kang, D. Recently, under the de-regulation environment, nuclear industry has attempted various approaches to improve the economics of Nuclear Power Plants NPP. This approach uses the risk and performance information to manage the resources effectively and efficiently that are used in the operation of NPP. The nuclear industry and regulatory body of U. A have developed a measure to evaluate the quality of PSA. However, in Korea, there have been no attempts to evaluate the quality of PSA model itself. Therefore, we cannot be sure about the quality of PSA whether or not the present PSA model can be used for the risk-informed applications such as mentioned above. We, also, have derived what items are to be improved to upgrade the quality of PSA model and how it can be improved. Il processo Andreotti. Il confine labile fra la partecipazione e il concorso esterno nei reati associativi. As a result of this analysis we come to ascertain how fleeting the boundary between the role of partecipant and external competitor in a criminal conspiracy can be, especially in case of. Informed consent is an essential element in doctor-patient relationship. In particular, obtaining valid informed consent from patients with neurocognitive diseases is a critical issue at present. For this reason, we decided to conduct research on elderly patients with Alzheimer's disease Diagnostic and Statistical Manual of Mental Disorders, 5th Edition DSM-5 to assess their capacity to make treatment decisions. The experimental group comprised 70 Alzheimer patients who were admitted to the Neurodegenerative Disease Unit of the University of Bari. The control group consisted of 83 elderly patients without neurocognitive disorders who were hospitalized in the Geriatric Unit at the same university. After providing written consent to participate in the research, each subject underwent the following assessments: a assessment of comprehension sheet, b Neuropsychiatric Inventory NPI and Global Functioning Evaluation GFE , c neurological evaluation, d neuropsychological assessment with a full battery of tests, d The MacArthur Treatment Competence Study MacArthur Competence Assessment Tool for Treatment MacCAT-T ; understanding, appreciating, reasoning and expressing a choice and e a semi-structured interview administered by the patient's caregiver. The present survey was designed to analyze possible qualitative and quantitative correlations between cognitive functioning and capacity to consent in relation to different degrees of severity of the neurodegenerative disorder. A large portion of the patients in our experimental sample did not appear to have the capacity to provide a valid consent. The authors present initial results of this study and discuss their possible implications. Chest pain and acute dyspnoea are frequent causes of emergency medical services activation. The pre-hospital management of these conditions is heterogeneous across different regions of the world and Europe, as a consequence of the variety of emergency medical services and absence of specific prac Valutazione morfo-funzionale in pazienti ipertesi con stenosi dell'arteria renale; Correlazioni tra angiografia e scintigrafia dinamica. Morpho-functional evaluation in hypertensive patients with renal artery stenosis; Correlations between angiography and radionuclide renography. Cattedra di Medicina Nucleare. By comparison with current version of Huang di nei jing, most of the descriptions are similar, yet still with some differences, such as yin-yang nature of the five zang visceras, the liver being the root of "pi ji", the spleen being the root of "cang lin" etc. Wu xing da yi epitomizes the books about yin-yang and five phases before the Sui Dynasty, while Xiao Ji's quotations from Huang di nei jing interpreted from the views of yin-yang and five phases, are different from the annotations of later ages. Hereditary haemorrhagic telangiectasia: study of hepatic vascular alterations with multi-detector row helical CT and reconstruction programs; Telangiectasia emorragica ereditaria: TC multidetettore multifasica e programmi di ricostruzione nello studio delle alterazioni vascolari epatiche. Centro Interdipartimentale per lo studio dell' HHT. Materials and methods: An MDCT multiphasic study of the liver was performed in consecutive patients: 89 considered to be affected by HHT and 16 with suspicion of disease alone. The scan delay was determined by using a test bolus of contrast material. The CT examination was performed with a triphasic technique double arterial phase and portal venous phase. Therefore HHT diagnosis was excluded in 5 patients. Conclusions: Multiphasic MDCT and the new reconstruction programs enable the identification and characterisation of the complex vascular alterations typical of HHT. Materiale e metodi: E' stato eseguito uno. Valutazione e mappatura dei servizi culturali nei paesaggi terrazzati. Il caso studio della Costiera Amalfitana. Full Text Available I paesaggi culturali rappresentano una risorsa fondamentale per lo sviluppo sostenibile. Attualmente molti paesaggi terrazzati sono considerati a rischio a causa delle mutate condizioni socio-economiche. Viene affrontato il tema della valutazione e mappatura dei servizi culturali, con riferimento al paesaggio terrazzato della Costiera Amalfitana in Campania. Le categorie di servizi sono state valutate con il coinvolgimento della comunità locale attraverso un questionario semi-strutturato somministrato online ad un campione di soggetti. Sia Rodari, sia Belgrano erano legati — seppure con diverse modalità — al Movimento di Cooperazione Educativa, che si proponeva di rinnovare la scuola italiana ispirandosi alla pedagogia deweyana. Absolute transition probabilities in the NeI 3p-3s fine structure by beam-gas-dye laser spectroscopy. La ricostruzione dell'immagine tridimensionale ha consentito la visualizzazionedella distribuzione spaziale delle fibre all'interno della matrice polimerica anche nel caso di fibre di piccole dimensioni diametro medio di 10 micrometri. E' stato quindi possibile misurare le differenze nell'orientamento delle fibre nei differenti strati di un campione utilizzando metodi basati sulla valutazione del Mean Intercept Length MIL e del fabric tensor. Vertebroplasty in the treatment of back pain; La vertebroplastica nel trattamento delle sindromi algiche del rachide. Non abbiamo mai effettuato la flebografia prima del trattamento. In 55 pazienti l'approccio e' stato bilaterale, mentre nei rimanenti e' stato monolaterale. Il posizionamento dell'ago e la iniezione del cemento e' stata effettuata sempre sotto controllo scopico. Le quantita' di cemento iniettate sono state variabili a livello dorsale o lombare con volumi compresi tra 12 e 4 ml. Il cemento utilizzato e' a bassa viscosita' opacizzato con diossido di zirconio, tantalio o solfato di bario sterile. Abbiamo riscontrato fughe di cemento extravertebrali vascolari o discali in 39 pazienti ma solo in 2 casi tali fughe hanno determinato la comparsa di una sintomatologia clinica radicolare per diffusione epidurale. Non abbiamo riscontrato mai nella nostra esperienza fratture a vertebre adiacenti trattate con vertebroplastica. Discussione e conclusioni: Sebbene i primi casi di vertebroplastica siano stati effettuati per il trattamento degli angiomi vertebrali, si e' subito passati ad applicare tale tecnica anche al trattamento dei crolli vertebrali da osteoporosi o da lesioni secondarie. La RM svolge un ruolo chiave nella corretta selezione dei pazienti da trattare mentre la TC puo' essere utile per valutare l'integrita' del muro posteriore del metamero. La controindicazione assoluta e' data da infezioni sistemiche e locali mentre quelle relative dalla estensione epidurale della neoplasia, dalla vertebra plana, dalla presenza di segni clinici di interessamento mielico o radicolare e da eventuali disturbi della coagulazione. I risultati da noi ottenuti evidenziano un successo che e. Properties and processing technologies of polymers for medical devices; Proprieta' e tecnologie di lavorazione dei polimeri utilizzati nei dispositivi medici. Apple, Amazon, Google y Facebook pagan sólo 22 millones a Hacienda. Bélgica ha establecido una compensación para el trabajador de ,48 euros al mes. Foto: Dreamstime. Ignacio Faes Javier Calvo. Teletrabajo Coronavirus Europa Trabajadores Empresas. Comparte esta noticia..

Chinese traditional medicine, as in Huang Di Nei Jing, considers the nourishment of body and mind. It also emphasises that herbal medicine and food have the same origin. Diet was essential to the prevention of disease which a glossary of Chinese terms is given at the end of the Vittorio colao esposa disfunción sexual in the Chinese tradition, was superior to treatment.

Treatment of TB requires long-term courses of multi-drug therapies to eliminate subpopulations of bacteria, which sometimes persist against Vittorio colao esposa disfunción sexual.

Therefore, understanding of the mechanism of Mtb antibiotic-resistance is extremely important. During infection, Mtb overcomes a variety of body defense mechanisms, including treatment with the reactive species of oxygen and nitrogen. The bases in DNA molecule are susceptible to the damages caused by reactive forms of intermediate compounds of oxygen and nitrogen. Most of this damage is repaired by the base excision repair BER pathway.

Methods: XthA, nfo, and nei genes were identified in mycobacteria by homology search of genomic sequences available in the GenBank database. The protein products of Mtb genes were expressed and purified in Escherichia coli using affinity tags. The enzymatic activity of purified Nfo, XthA, and Nei 2 proteins were measured using radioactively labeled DNA substrates containing various modified residues.

The plasmid constructs were verified by sequencing and then transformed into the Escherichia coli BL21 DE3 strain. Identification of the isolated proteins was performed by. The aim of this study was to evaluate different approaches to scoring the National More info Institute Visual Functioning Questionnaire NEI Vittorio colao esposa disfunción sexual in patients with low vision including scoring by the standard method, by Rasch analysis, and by use of an algorithm created by Massof to approximate Rasch person measure.

Subscale validity and use of a 7-item short form instrument proposed by Ryan et al. NEI VFQ data from 50 patients with low vision were analyzed using more info standard method of summing Likert-type scores and calculating an overall Vittorio colao esposa disfunción sexual, Rasch analysis using Winsteps software, and the Massof algorithm in Excel.

Correlations between scores were calculated. Rasch person separation reliability and other indicators were calculated to determine the validity of the Vittorio colao esposa disfunción sexual and of the 7-item instrument. Scores calculated using all three methods were highly correlated, but evidence of floor and ceiling effects was found with the standard scoring method. None of the subscales investigated proved valid.

The 7-item instrument showed acceptable person separation reliability and good targeting and item performance. Although standard scores and Rasch scores are highly correlated, Rasch analysis has the advantages of eliminating floor and ceiling effects and producing interval-scaled data.

The Massof algorithm for approximation of the Rasch person measure performed well in this group of low-vision patients. The validity of the subscales VFQ should be reconsidered. Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle. We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine-amide NEI concentrations in discrete brain areas in male rats.

To investigate the Vittorio colao esposa disfunción sexual effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone LHestradiol and progesterone concentrations were measured in control, hypothyroid hypoT, treated with PTU during days and hyperthyroid hyperT, l-T4 during days animals.

Both treatments blunted the LH surge. Hypo- and hyperthyroidism increased estradiol concentrations during proestrus afternoon P-PMalthough hypoT rats showed lower values compared to control during proestrus morning P-AM. NEI concentrations were lower in hypoT rats during the estrous cycle except in estrus E in the peduncular part of the lateral hypothalamus PLH.

The present results indicate that NEI concentration is regulated in a complex manner by hypo- and hyperthyroidism in the different areas studied, suggesting a correlation between NEI values and the variations of gonadal steroid levels during estrous cycle.

These changes could be, in part, responsible for the alterations observed in the hypothalamic-pituitary-gonadal axis in these pathologies. Prostatic biopsy in the prostate specific antigen gray zone; La biopsia prostatica multipla nalla zona grigia dei valori dell'antigene prostatico specifico.

Drudi, F. La Sapienza, Rome Italy. Of the patients who gave full informed consent, 34 people were selected whose age range was between 56 to 76 years mean: PSA velocity Vittorio colao esposa disfunción sexual calculated collecting 3 blood samples every 30 days for 2 months. Our findings confirm that prostatic biopsy can detect tumors also in areas which appear normal at transrectal US and digital examination, and that PSA rate increases in patients with positive histology.

Finally, the actual clinical role of prostatic biopsy relative to all other diagnostic imaging techniques remains to be defined. Di questi sono stati selezionati eta' tra 56 e 76 anni, eta' media 64 anni. Energy and telecommunications public services; Servizi pubblici nei settori dell'energia e delle telecomunicazioni. Salini, M. The aim of this work is the evolution of the energy and telecommunication public services.

The article runs through the main stages in the public services' history and shows how open market rules may cause the future dissolution of public service notion. The conclusion wishes the hastening of public services privatisation and a Corporate Governance reform as a mean to pursue general interest. Se ne ripercorrono le principali tappe storiche e si evidenzia come le regole di apertura Vittorio colao esposa disfunción sexual mercati possano causare la dissoluzione del concetto di servizio pubblico.

Le conclusioni sottolineano la necessita' di accelerare la https://txt-l.iqsenso.store/video-2020-04-01.php dei servizi pubblici e la riforma della Corporate Governance come strumento per il raggiungimento dell'interesse generale.

The role of 3D Helical CT in the reconstructive treatment of maxillofacial cancers; Tomografia Computerizzata spirale con elaborazioni tridimensionali di superficie nel trattamento ricostruttivo dei tumori maligni del massiccio facciale.

De Rosa, V. Nazionale Tumori Fondazione G. Pascale, Naples Italy ; Parascandolo, S. Further Ti features are strength, biocompatibility and easy this web page. The prospect is provided to identify virtual 3D presurgical ablation planes.

pregnacy porn Watch Porn Movies Sexy Latinas. The sera collected during the initial six weeks of experimental As expected, virus neutralization tests using homologous virus were able to differentiate the two groups infected It was found that immunoassays using whole virus and polyclonal antibodies are the most robust, but all tests examined were able to detect Molecular identification of a new pestivirus associated with increased mortality in the Pyrenean Chamois Rupicapra pyrenaica pyrenaica in Spain. Pestivirus infection was identified in 16 of 17 chamois during an outbreak of a previously unreported disease in Pyrenean chamois Rupicapra pyrenaica pyrenaica in northeastern Spain in By analysis of the 5' noncoding regions of the virus, we assigned it to the border disease virus cluster with pairwise similarity values ranging from It will be important to investigate the association of this pestivirus with disease in Pyrenean chamois. Seroprevalence of pestivirus in four species of alpine wild ungulates in the High Valley of Susa, Italy. Wildlife, once infected, can serve as a reservoir of infectious diseases that form a constant threat to domestic livestock. To make control and eradication programs successful in the long-term, presence of pestivirus in wildlife populations should be monitored. The goal of this study was to investigate seroprevalence of pestivirus in four alpine wild ungulates in the High Valley of Susa, north-west Italy. Species studied were: red deer Cervus elaphus , roe deer Capreolus capreolus , wild boar Sus scrofa and chamois Rupicapra rupicapra. A further goal was using virus neutralisation tests VNT for four strains of pestivirus in chamois and wild boar. Three hundred and seventy-five serum samples collected during the hunting season of were tested for pestivirus specific antibodies. Positive sera of chamois and wild boar were subsequently tested in a VNT with four major subtypes of pestivirus , and virus isolation was performed. No antibodies were found in the 73 samples of roe deer, while 7 Several possibilities, which might explain the high seroprevalence in chamois are discussed. Pestivirus antibodies were found in three out of four large alpine ungulates in the High Valley of Susa. Seroprevalence was particularly high in chamois. Further investigation is needed to characterise the pestiviruses that circulate in these animals. A multiplex RT-PCR assay for the rapid and differential diagnosis of classical swine fever and other pestivirus infections. Classical swine fever is a highly contagious viral disease causing severe economic losses in pig production almost worldwide. All pestivirus species can infect pigs, therefore accurate and rapid pestivirus detection and differentiation is of great importance to assure control measures in swine farming. Here we describe the development and evaluation of a novel multiplex, highly sensitive and specific RT-PCR for the simultaneous detection and rapid differentiation between CSFV and other pestivirus infections in swine. The universal and differential detection was based on primers designed to amplify a fragment of the 5' non-coding genome region for the detection of pestiviruses and a fragment of the NS5B gene for the detection of classical swine fever virus. The assay proved to be specific when different pestivirus strains from swine and ruminants were evaluated. The analytical sensitivity was estimated to be as little as 0. The assay analysis of 30 tissue homogenate samples from naturally infected and non-CSF infected animals and 40 standard serum samples evaluated as part of two European Inter-laboratory Comparison Tests conducted by the European Community Reference Laboratory, Hanover, Germany proved that the multiplex RT-PCR method provides a rapid, highly sensitive, and cost-effective laboratory diagnosis for classical swine fever and other pestivirus infections in swine. Experimental inoculation of calves with atypical Hobi-like pestivirus shows pattern similar to BVDV The experiment The pathogenesis of the infection with Hobi-like viruses has not yet been fully elucidated. The purpose of our study was to investigate the course Concurrent peste des petits ruminants virus and pestivirus infection in stillborn twin lambs. Concurrent infection with peste des petits ruminants virus PPRV and pestivirus was diagnosed in stillborn twin lambs. Macroscopic anomalies that were typical of border disease included scoliosis, brachygnathism, prognathism, arthrogryposis, hydranencephaly, cerebellar hypoplasia, and hairy fleece; pestiviral antigen was detected by IHC in the brain, liver, lungs, and kidneys. To the authors' knowledge, PPR has not been reported previously as a congenital infection or in combination with pestiviral infection. Genome analysis of an atypical bovine pestivirus from fetal bovine serum. Alignment of the complete nucleotide sequence and phylogenetic analysis indicate that this viral isolate belongs to atypical pestiviruses. Sequence-based comparative study of classical swine fever virus genogroup 2. This study was undertaken with the aim to compare and establish the genetic relatedness between classical swine fever virus CSFV genogroup 2. The complete genome sequence, complete open reading frame, 5' and 3' non-coding region NCR sequences were analyzed and compared with reference pestiviruses strains. Clustal W model in MegAlign program of Lasergene 6. Phylogenetic analysis was carried out using MEGA 6. Sequence homology of 5' and 3' NCRs was found to be In phylogenetic analysis, overall tree topology was found similar irrespective of sequences used in this study; however, whole genome phylogeny of pestivirus formed two main clusters, which further distinguished into the monophyletic clade of each pestivirus species. Integrando empresas e cooperativas de catadores em fluxos reversos de resíduos sólidos pós-consumo: o caso Vira-Lata. Esta pesquisa analisa os desafios e as perspectivas para o desenvolvimento dessas iniciativas. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Pestiviruses are economically important pathogens of livestock. The aim of this study was to determine the scope of antiviral activity of DB among diverse pestiviruses. Cytotoxicity of the compound was assayed for each cell type. In two of three tests, a concentration of 0. Bungowannah virus was completely inhibited at a concentration of 0. As cytotoxicity is not evident at these concentrations, this antiviral compound potentially represents an effective preventative or therapeutic for diverse pestiviruses. Full Text Available Enveloped viruses have developed various adroit mechanisms to invade their host cells. This process requires one or more viral envelope glycoprotein to achieve cell attachment and membrane fusion. Members of the Flaviviridae such as flaviviruses possess only one envelope glycoprotein, E, whereas pestiviruses and hepacivirus encode two glycoproteins, E1 and E2. Although E2 is involved in cell attachment, it has been unclear which protein is responsible for membrane fusion. We report the crystal structures of the homodimeric glycoprotein E2 from the pestivirus bovine viral diarrhea virus 1 BVDV1 at both neutral and low pH. Our results suggest that the pestivirus and possibly the hepacivirus fusion machinery are unlike any previously observed. Presence of atypical porcine pestivirus APPV genomes in newborn piglets correlates with congenital tremor. Pestiviruses are highly variable RNA viruses belonging to the continuously growing family Flaviviridae. Here, a screening of sera from apparently healthy adult pigs demonstrated the existence of APPV in Germany with an estimated individual prevalence of 2. Additionally, APPV genomes were detected in newborn piglets affected by congenital tremor CT , but genomes were absent in unaffected piglets. High loads of genomes were identified in glandular epithelial cells, follicular centers of lymphoid organs, the inner granular cell layer of the cerebellum, as well as in the trigeminal and spinal ganglia. Retrospective analysis of cerebellum samples from demonstrated that APPV can be found in piglets with CT of unsolved aetiology. APPV sequences derived from different regions in Germany demonstrated to be highly variable. Taken together, the results of this study strongly suggest that the presence of APPV genomes in newborn piglets correlates with CT, while no association with clinical disease could be observed in viremic adult pigs. Pestivirus in alpine wild ruminants and sympatric livestock from the Cantabrian Mountains, Spain. Results showed a higher seroprevalence in cattle Conversely to other similar grazing systems, sheep flocks did not play a relevant role in the pestivirus epidemiology in this region. Pestivirus infections in wild ruminants were sporadic and most probably dependent on a domestic source. This study describes the use of a novel and rapid long reverse transcription RT -PCR for the generation of infectious full-length cDNA of pestiviruses. Infectious virus was obtained after one cell culture passage. The rescued viruses had a phenotype similar to the parental Border Disease virus strain. Summary Enveloped viruses have developed various adroit mechanisms to invade their host cells. Experimental infection of cattle, sheep and pigs with 'Hobi'-like pestivirus. To date, limited information is available on the ability of 'Hobi'-like pestiviruses putative bovine viral diarrhoea 3 to infect and cause disease in animal species traditionally affected by pestiviruses. Appearance of clinical signs, leukopenia, viremia, viral shedding and seroconversion were monitored for 28 days post-infection. Calves and lambs were successfully infected, displaying respiratory signs nasal discharge , moderate hyperthermia and leukopenia, viremia and viral shedding through the nasal and faecal routes. In contrast, inoculated piglets did not display any clinical signs nor leukopenia and viral RNA was not detected in any biological samples. Nevertheless, the presence of detectable antibodies by virus neutralisation accounted for a successful, albeit limited infection of these animals. A structural model of pestivirus E rns based on disulfide bond connectivity and homology modeling reveals an extremely rare vicinal disulfide. Erns is a pestivirus envelope glycoprotein and is the only known viral surface protein with RNase activity. Erns is a disulfide-linked homodimer of kDa; it is found on the surface of pestivirus -infected cells and is secreted into the medium. In this study, the disulfide arrangement of the nine. The strategy applied in this study is useful for classifying novel pestiviruses in the future. Natural infection of cattle with an atypical 'HoBi'-like pestivirus --implications for BVD control and for the safety of biological products. The results from virus neutralisation tests performed on sera collected from cattle in the herd of the infected calf, showed that these cattle had markedly higher antibody titres against the atypical pestivirus 'HoBi' than against Bovine Viral Diarrhoea Virus types 1 and 2, or Border Disease Virus. The results also supported, consequently, the results from the molecular analysis, and demonstrated that a 'HoBi'-like pestivirus had been introduced to, and was now circulating in the herd. This study is the first to report a natural infection in cattle with a virus related to this atypical pestivirus , and it suggests that this group of pestiviruses may already be spread in cattle populations. The findings have implications for BVD control and for the biosafety of vaccines and other biological products produced with foetal calf serum. Consequently, these atypical pestiviruses should be included in serological assays, and any diagnostic assay aimed at detection of pestiviruses in biological products or animals should be tested for its ability to detect them. Congenital tremors is a sporadic disease of neonatal pigs characterized by action-related repetitive myoclonus. A majority of outbreaks of congenital tremors have been attributed to an unidentified virus. The objectives of this project were to 1 detect potential pathogen s in samples from piglets with congenital tremors and 2 develop an infection model to reproduce disease. Using next-generation sequencing, a divergent lineage pestivirus was detected in piglets with congenital tremors. The virus was originally most closely related to a bat pestivirus but is now more closely related to a recently published novel porcine pestivirus provisionally named atypical porcine pestivirus. A quantitative real-time PCR detected the virus in samples from neonatal piglets with congenital tremors from two separate farms, but not in samples from unaffected piglets from the same farm. To fulfill the second objective, pregnant sows were inoculated with either serum containing the pestivirus or PBS control by intravenous and intranasal routes simultaneously with direct inoculation of fetal amniotic vesicles by ultrasound-guided surgical technique. Inoculations were performed at either 45 or 62 days of gestation. All sows inoculated with the novel pestivirus farrowed piglets affected with congenital tremors while PBS-inoculated control piglets were unaffected. Tremor severity for each piglet was scored from videos taken 0, 1 and 2 days post-farrowing. Tremor severity remained relatively constant from 0 to 2 days post-farrowing for a majority of piglets. The virus was consistently detected by PCR in tissues from piglets with congenital tremors but was not detected in control piglets. Full Text Available Congenital tremors is a sporadic disease of neonatal pigs characterized by action-related repetitive myoclonus. Detection and genetic identification of pestiviruses in Brazilian lots of fetal bovine serum collected from to Thirty-nine lots Six lots 8. Four FBS batches 5. Five batches 6. The high frequency of contamination of FBS with pestivirus RNA reinforce the need for systematic and updated guidelines for monitoring this product to reduce the risk of contamination of biologicals and introduction of contaminating agents into free areas. Recombinant pestivirus E2 glycoproteins prevent viral attachment to permissive and non permissive cells with different efficiency. Bovine viral diarrhoea virus BVDV is an economically important animal pathogen, which like other pestiviruses has similar molecular biological features to hepaciviruses, including human Hepatitis C virus. The pestivirus E2 glycoproteins are the major target for virus-neutralising antibodies, as well as playing a role in receptor binding and host range restriction. In this study, recombinant E2 glycoproteins rE2 derived from three different pestivirus species were examined for their inhibitory effects on pestivirus infectivity in cell culture. The ability of rE2 glycoprotein to inhibit the infection of permissive cells by both homologous and heterologous virus was compared, revealing that the inhibitory effects of rE2 glycoproteins correlated with the predicted similarity of the E2 structures in the recombinant protein and the test virus. This result suggests that the sequence and structure of E2 are likely to be involved in the host specificity of pestiviruses at their point of uptake into cells. Genomic and antigenic relationships between two 'HoBi'-like strains and other members of the Pestivirus genus. To date, few complete genome sequences of 'HoBi'-like viruses are available in public databases. Moreover, detailed analyses of such genomes are still scarce. In an attempt to expand data on the genetic diversity and biology of pestiviruses , two genomes of 'HoBi'-like viruses recovered from Brazilian cattle were described and characterized in this study. Analysis of the whole genome and antigenic properties of these two new 'HoBi'-like isolates suggest that these viruses are genetically close to recognized pestiviruses. The present data provide evidence that 'HoBi'-like viruses are members of the genus Pestivirus and should be formally recognized as a novel species. The viral envelope is not sufficient to transfer the unique broad cell tropism of Bungowannah virus to a related pestivirus. Bungowannah virus is the most divergent pestivirus , and both origin and reservoir host have not been identified so far. We therefore performed in vitro tropism studies, which showed that Bungowannah virus differs remarkably from other pestiviruses. Interestingly, cell lines of vervet monkey, mouse, human and even of bat origin were susceptible. This broad in vitro tropism was not observed for a chimeric bovine viral diarrhoea virus BVDV expressing all structural proteins of Bungowannah virus. The viral envelope was not sufficient to completely transfer the cell tropism of Bungowannah virus to another pestivirus , and viral RNA replication was either markedly reduced or not detectable in a number of different cell lines for the tested BVDV strain and the chimera. We therefore suggest that the replication machinery together with the viral envelope is responsible for the unique broad cell tropism of Bungowannah virus. Numerical taxonomy of the genus Pestivirus : new software for genotyping based on the palindromic nucleotide substitutions method. Pestivirus identification using PNS was evaluated on five hundred and forty-three sequences at genus, species and genotype level using this software. The software is freely available at www. A serosurvey for ruminant pestivirus exposure conducted using cattle sera collected for brucellosis surveillance in the United States. Four species of ruminant pestivirus are currently circulating in the United States: Bovine viral diarrhea virus 1 and 2 BVDV-1, -2; predominant host: cattle , Border disease virus BDV; predominant host: sheep , and pronghorn virus sporadically detected in wild ruminants. A third bovine pestivirus called HoBi-like virus has been detected in cattle and water buffalo in South America, Asia, and Europe. To date, no isolations of HoBi-like viruses from U. To assess exposure, 2, cattle sera, collected between and as part of the U. In addition, RNA was extracted and tested by reverse transcription-polymerase chain reaction for the presence of pestiviruses ; all samples tested negative. The percent of VN-positive samples was Because the 3 bovine pestiviruses are antigenically cross-reactive, the comparative level of antibody against each pestivirus species was determined. Based on comparative titers, samples were segregated into 6 categories: no titers 7. X-ray structure of the pestivirus NS3 helicase and its conformation in solution. Pestiviruses form a genus in the Flaviviridae family of small enveloped viruses with a positive-sense single-stranded RNA genome. Viral replication in this family requires the activity of a superfamily 2 RNA helicase contained in the C-terminal domain of nonstructural protein 3 NS3. The structure deviates significantly from that of NS3 of other genera in the Flaviviridae family in D3, as it contains two important insertions that result in a narrower nucleic acid binding groove. We also show that mutations in pNS3h that rescue viruses from which the core protein is deleted map to D3, suggesting that this domain may be involved in interactions that facilitate particle assembly. Finally, structural comparisons of the enzyme in different crystalline environments, together with the findings of small-angle X-ray-scattering studies in solution, show that D2 is mobile with respect to the rest of the enzyme, oscillating between closed and open conformations. El mal paso por los Diablos Rojos le hizo reflexionar que su tiempo en los banquillos se terminó. En su trayectoria conquistó un título de Liga, con el Atlante en la temporada Al Ascenso MX ya no hay quien lo salve. Al nuevo experimento del futbol mexicano, hasta el momento conocido como Liga de Expansión, le falta mucho por desarrollar, sobre todo cinco puntos para consolidar sus bases. Sin olvidar que es posible que algunos de los 12 clubes del extinto Ascenso MX puedan dar un paso al costado. En caso de que se implemente para menores de 23 años de edad, jugadores no cumplen con la restricción y se quedarían sin cupo en la Liga de Expansión. Bonilla tiene en mente consolidar una fuente estable de ingresos, como los derechos televisivos, por lo que conquistar a empresas para transmitir los partidos, a nivel regional y nacional, es prioridad. Diversos directivos argumentaron que la crisis económica en el Ascenso MX fue la principal razón para crear este formato, sin opción a Primera División. Constatando esta entrega estuvieron los representantes de Gobierno del Estado de Chiapas, por parte de la Delegación Regional de Protección Civil estuvo Julisa Briones; el delegado de Gobierno en la región, Efraín García Ordóñez, quien invitó a los representantes de ambas dependencias municipales a darle buen uso a las unidades, y hablando en. El Presidente Municipal estuvo acompañado de su Cabildo así como de Moisés Villarreal Hurtado, secretario de Protección Civil Municipal, y del tesorero municipal, Luis Vicente Justiniano Wong, quien comentó que gracias al apoyo y planeación del Cabildo se pudo obtener recursos para la compra de las unidades. De acuerdo al Servicio. Sismológico Nacional SSN , el epicentro se ubicó a kilómetros al suroeste de Ciudad Hidalgo, en el municipio de Suchiate, segundos después de las horas. En los primeros 23 días de Abril, Chiapas ha sido escenario de temblores, mientras que en al año se han contabilizado mil , es decir, un promedio cercano a los diez diarios. Por lo mismo, la Comisión Nacional del Agua Conagua hizo un estudio técnico y concluyó que la red, ubicada en la prolongación de la 17 Oriente, debería reconstruirse, pero evitando el afluente. Los recursos que se requerían para corregir la obra fueron autorizados por el Gobierno Federal y ya se iniciaron los trabajos. La autorización de la obra que hizo la Conagua y las acciones que lleva a cabo,. De acuerdo a la opinión de Martínez López, si se continuaba dejando la red en el mismo lecho del río se iba a seguir contaminando y corría el riesgo de dañarse por alguna inundación. Así también, que la mejor alternativa, a criterio de la Conagua, fue pasarla por arriba de la banqueta y cubrir la. Esa técnica ya se ha hecho en otros puntos de la ciudad, en. Se desconoce si. En entrevista para EL ORBE, reconoció la importancia del transporte colectivo por la necesidad que tienen de trasladarse desde sus comunidades hacia cualquier punto del municipio y viceversa, sobre todo para realizar la compra de alimentos y medicinas, o para ir al trabajo. Cabe señalar que en el documento se incluyen nueve. Durante una reunión virtual de la mesa técnica, la diputada Barrera Badillo destacó la importancia de que los legisladores revisen la propuesta de dictamen y emitan sus consideraciones, para procesarlas y se apruebe, una vez que se reanuden las actividades presenciales. También, la mesa técnica. Comunicado de Prensa. En entrevista exclusiva para EL ORBE reveló que tienen conocimiento de que hay muchos migrante infectados en Estados Unidos, tanto libres como asegurados en centros de detención. Ahí hay al menos 20 migrantes detenidos que han dado positivo a la pandemia, pero que lo. En esa misma ciudad hay otras 15 persona que ya dieron positivo, pero no se sabe como fue el mecanismo de contagio y si tuvieron algo que ver los migrantes. En el caso de Tapachula, indicó que tuvieron conocimiento de un migrante retenido en la Estación Migratoria Siglo XXI y que, por lo mismo, solicitaron informes al Instituto Nacional de Migración INM , pero que no les quisieron dar respuestas. Entrevistado a un costado de la alcaldía, indicó que los migrantes se sienten protegidos por los convenios que ha hecho el gobierno federal mexicano con la Organización de las Naciones Unidas ONU de abrir las puertas del país y hasta mantenerlos con subsidios económicos. Hasta ayer 23 de Abril, se reportaron en Italia , casos de infectados, 25, de muertos y 57, recuperados. Asimismo, se informó de nuevos pacientes recuperados. Italia se encuentra en el puesto 3 de países con mayor cantidad de infectados. De las , personas actualmente positivas, 81, se encuentran en aislamiento domiciliario, 22, internadas con síntomas y en terapia intensiva. En entrevista, Ramírez Leal comentó que en la construcción del Aeropuerto Internacional de Santa Lucía hay una gran oportunidad de emplear a trabajadores de constructoras formales que pagan impuestos. Pero las constructoras han sido desplazadas de. Ramírez Leal dijo que las constructoras han sido estigmatizadas debido a que algunas empresas nacionales y extranjeras abusaron en sexenios pasados, por lo que dejaron hospitales y carreteras a medias, o como en el Tren. En este marco, Llaven Abarca señaló que la asociación ciudadana de manera imparcial y transparente en su reporte correspondiente a los meses de Enero, Febrero y Marzo, informó que Chiapas junto con Baja California Sur y Sinaloa fueron los Estados mejores evaluados por el índice de sus indicadores delictivos. Diabetes, hipertensión, obesidad y tabaquismo son las enfermedades que. Veracruz, Sinaloa y Nayarit son Estados con un panorama similar. Reconocemos en la prevención la vía para evitar la muerte y la desolación. Se precisa unidad para afrontar los desafíos económicos. En los tres, la hipertensión es el mayor riesgo para los pacientes. Reiteró que la extensión de la Jornada Nacional de Sana Distancia hasta finales de Mayo, tiene como objetivo reducir en mayor medida la afectación a la población, por ello es fundamental que la sociedad colabore y de esa manera no saturar los servicios de salud. Comentó que sumado a la convocatoria de permanecer en el hogar, es fundamental organizarse con los integrantes de la familia para que sea un solo miembro el que salga a realizar la compra de alimentos, medicinas y productos de primera necesidad, pero tomando todas las medidas de protección. M éxico. La mitad de estas personas -unas mil- acudiría a atención médica y alrededor de 10 mil requerirían terapia intensiva. Expuso que Locatel, a través de los mensajes SMS, ha atendido mil cuestionarios completados; de estos, 3 mil se han reconocido como sospechoso y este miércoles hubo traslados; 41 de Cruz Roja, 81 del ERUM, cuatro de ambulancias particulares, dos de las alcaldías y ocho de la Secretaría de Salud. Viernes 24 de Abril de De la intensa conferencia matutina de antier miércoles 22 y en lo referido a la crítica a la prensa crítica, valdría el esfuerzo histórico para hacer unas precisiones referidas a caracterizaciones de periodistas buenos y periodistas malos. Los hermanos Flores Magón usaron su periódico Regeneración como espacio militante en la lucha del Partido Liberal contra Díaz, padrino de bautizo, por cierto, de uno de ellos; por lo tanto, se trató de un periodismo parcial, partidista, excluyente, ideológico y El revolucionario. Me ha tocado criticar, comentar y cuestionar, desde este espacio, las acciones, dichos y decisiones Escojan: hay Periodismo de Estado, de Militancia e Independiente Crítico Tapachula, Chiapas. Viernes 24 de Abril de La psicosis en la población mundial se incrementa con la noticia de que dos gatos resultaron positivos por Coronavirus en Nueva York, Estados Unidos. Ciertamente, el decreto del 21 de Abril no crece los programas ni tampoco el padrón de sus Oscar D. Y el Presidente tiene la obligación constitucional de ver por todos y no solo por una parte de los afectados. Tasa de letalidad global: 6. La OMS clasifica la distribución de casos por regiones. Fuente: Ssa Tapachula, Chiapas. Durante su participación, el presidente de la Junta de Coordinación Política del Congreso, Marcelo Toledo Cruz, reconoció la solidaridad del Poder Legislativo al aprobar, por unanimidad, la autorización para que las y los alcaldes destinen hasta 25 por ciento de los recursos del Fondo General de Participaciones del Ramo General 28, el 10 por ciento de ingresos libres de los recursos presupuestales del ejercicio , y hasta el 5 por ciento del Fondo de Aportaciones al Fortalecimiento Municipal. Especialidad - Enfermedades del corazón - Hipertensión arterial - Electrocardiogramas - Ecocardiogramas: bidemensional - Doppler color, continuo y pulsado. Oriente No. SSA NO. DE AUT. T apachula, Chiapas; 23 de abril. Ante estos hechos se presentó la denuncia ante las autoridades ministeriales, para que inicien las investigaciones y determinen quién de los empleados tomó ese dinero, para que sea castigado. Las fuertes llamas envolvieron la caseta que estaba construida de madera, quedando reducido a cenizas, en donde se presume que un corto circuito dio inicio a la conflagración. A pesar de la intensidad del fuego, no se reportaron personas lesionadas ni intoxicadas, por lo que después de varios minutos de trabajo, se logró controlar la situación. SUN C hile; 23 de abril. Solicitó al Emergencias, la presencia de las diferentes corporaciones policiacas, quienes arribaron al lugar y después de verificar los hechos revisaron a la persona que se encontraba a un costado de la cama y confirmaron que estaba sin vida. Al arribar esta mañana después de estar tocando y no recibir respuesta, abrió el negocio con sus llaves y lo encontró tirado, desnudo y boca abajo. Presuntamente se debió al exceso de velocidad al que una persona conducía un automóvil Volkswagen Jetta de color azul, con placas de circulación del estado de Chiapas y eso provocó que al pasar por una curva perdiera el control y volcara. Roberto Armas Guillén U. Centro, Tapachula, Chis. Bastante amplio, en excelente ubicación en pleno centro de la ciudad. Edgar V. Teléfono , Por expansión solicita: Choferes Vendedores Requisitos: - Con experiencia - Solicitud de empleo requisitada - Estudios mínimos preparatoria - Dos cartas de recomendación - Comprobante de domicilio - Licencia de manejo vigente - INE - Acta de nacimiento - Constancia de no antecedentes penales Interesados comunicarse al Teléfono 62 ó al Celular , o acudir a entrevista en 3a. Viernes 24 de Abril de La Pontificia Universidad Católica de Chile ofrece este programa de 8 horas de duración que describe los principales componentes de la gestión de proyectos sin pérdidas lean project management. Norte, Col. Clínica Santa María Lic. Avenida Norte 86 Entre 13a. Poniente Col. Fanny J. Gómez Ozuna Céd. Poniente, Tapachula, Chiapas. Compartir en Facebook. Temas relacionados:. Abbiamo valutato i risultati di 72 biopsie ripetute in pazienti con una diagnosi di PIN ad una prima agobiopsia prostatica ecoguidata. A tutti e stato effettuato un numero minimo di 6 prelievi. I risultati sembrano confermare che il PIN puo essere considerato un precursore dell'adenocarcinoma prostatico o un'alterazione istologica frequentemente associata ad esso. I pazienti con diagnosi iniziale di PIN a basso grado e soprattutto quelli con PIN ad alto grado dovrebbero sistematicamente essere sottoposti a biopsia ripetuta a breve distanza per l'elevata frequenza di diagnosi finale di carcinoma. Non esistono ancora indicazioni condivise sull'intervallo temporale tra le due biopsie. Le variazioni del PSA che si possono riscontrare durante il periodo di osservazione non rappresentano un parametro statisticamente significativo per proporre o meno al paziente la ripetizione della biopsia prostatica. Hemodynamic effects of a prostacyclin analog Prostavasin in systemic sclero-derma patients; Effetti di un analogo della prostaciclina Prostavasin sui parametri Doppler nei pazienti con sclerodermia. Politecnica delle Marche, Ancona Italy. Istituto di radiologia. Il gruppo di studio GS e composto da 50 pazienti affetti da sclerodermia con anamnesi negativa per malattie cerebrovascolari, epatopatie, nefropatie e oftalmopatie. In tutti i pazienti e stata studiata la vasodilatazione endotelio-mediata dell'arteria brachiale tramite la misurazione del diametro trasverso con sonda ad alta risoluzione; sono stati anche misurati l'indice di resistenza IR delle arterie cerebrale media, centroretinica, epatica propria, mesenterica superiore e renali, in condizioni basali e dopo tre giorni di terapia. AI fine di valutare la variabilita intra-osservatore delle misurazioni, e stato reclutato un gruppo di controllo GC composto da 10 volontari sani che sono stati studiati con il medesimo protocollo Doppler e rivalutati a distanza di tre giorni senza ricevere alcuna terapia. Il GS ha dimostrato un significativo incremento della dilatazione endotelio-mediata dell'arteria brachiale, del diametro e della velocita media di flusso portale, dell'IP dell'arteria splenica all'ilo pre-Prostavasin vs post-Prostavasin, p pazienti del GS pur non risultando statisticamente significativi. Nel campione esaminato il Prostavasin ha dimostrato una potente azione vasodilatatoria prevalentemente a livello periferico ed ha incrementato la velocita media di flusso portale ed il diametro della vena porta, ma anche l'IP dell'arteria splenica all'ilo, non supportando l'ipotesi formulata da altri autori di una sua azione mirata e specifica sulle resistenze intraepatiche. Gisonni, P. Federico 2. L'identificazione del miocardio malfunzionante ma ancora vitale ha particolare rilevanza nel predire il recupero della funzione ventricolare in seguito a interventi di rivascolarizzazione coronarica. Relationship between exercise capacity and left ventricular function at rest in patients with heart failure. An ambulatory left ventricular monitoring study; Relazione tra capacita' di esercizio e funzione ventricolare sinistra a riposo nei pazienti con insufficienza cardiaca. Studio mediante monitoraggio continuo radionuclidico della funzione ventricolare sinistra. Pace, L. Medicina Nucleare; Romano, M. Medicina Interna. Purpose of this work is to evaluate the relationship of systolic and diastolic function at rest to exercise capacity. Seventeen patients with ischemic heart failure were included in the study. Ambulatory left ventricular monitoring at rest and during upright exercise with combined analysis of pulmonary gas exchange was performed. Ejection fraction, end-diastolic volume, end-systolic volume, stroke volume, cardiac output, and peak filling rate were measured. Sono stati studiati 17 pazienti con insufficienza cardiaca di origine ischemica. Tutti sono stati sottoposti a monitoraggio radionuclidico continuo della funzione ventricolare sinistra in combinazione con. Interstitial laser photocoagulation in the treatment of liver tumors. Personal technique, short term results and complications in patients with normal and impaired liver function; Fotocoagulazione laser-interstiziale ecoguidata dei tumori maligni del fegato: tecnica personale, risultati immediati e complicanze a breve termine nei pazienti con funzionalita' epatica normale e alterata. Giorgio, A. Cotugno, Naples Italy. Servizio di Ecografia ed Ecointerventistica; Catalano, O. Servizio di Radiologia; Alalia, A. II, Naples Italy. The work reports the personal experience with interstitial laser photocoagulation in patients with liver tumors mostly cirrhotics with hepatocellular carcinoma. The aim was to evaluate the short term efficacy of percutaneous interstitial laser photocoagulation in inducing focal ablation of liver tumors and the possible complications in patients with normal and impaired liver function. Lo scopo e' quello di verificare l'efficacia terapeutica in termini di volume di necrosi e di valutare gli effetti collaterali e le complicanze a breve termine sulla riserva funzionale del fegato e di altri organi, soprattutto nei pazienti con alterata funzionalita' epatica. Ricerca clinico-epidemiologica sullo stato di salute del cavo orale nei pazienti tossicodipendenti. Obiettivo: Lo scopo della ricerca è stato quello di mettere in evidenza la presenza di patologie del cavo orale in soggetti tossicodipendenti Materiali e Metodi: Sono stati reclutati 71 pazienti in terapia di recupero presso la Comunità Incontro di Amelia. I soggetti sono stati sottoposti a visite clinico-anamnestiche adottando una cartella clinica da noi stessi costruita. Risultati: Dei 71 soggetti tossicodipendenti, 42 facevano uso di eroina e 39 assumevano droghe per v Personal experience on 71 consecutive patients with acute cholecystitis; Esperienza personale in settantuno pazienti consecutivi con colecistite acuta. Pinto, A. Cardarelli, Neaples Italy. Federico 2, Neaples Italy. Nell'arco di tempo di 16 mesi, 71 pazienti consecutivi 42 femmine e 29 maschi con eta' compresa tra 34 e 84 anni, eta' media 58 anni con sintomatologia addominale acuta sono stati operati per colecistite acuta presso l'Azienda Ospedaliera A. Cardarelli di Napoli. L' esame diretto dell'addome e' stato eseguito in 65 casi su 71, l'ecografia addominale in 69 e la TC in 6. All'esame TC dell'addome sono stati ricercati: distensione della colecisti, ispessimento delle pareti colecistiche, contenuto endocolecistico, liquido pericolecistico e alterazioni di tipo infiammatorio nel grasso pericolecistico. L'ecografia rappresenta la metodica di scelta nello studio della colecistite acuta giacche' consente nella maggioranza dei casi di formulare la diagnosi definitiva. La TC riveste un ruolo trascurabile nella valutazione iniziale dei pazienti con colecistite acuta. Essa puo' essere utile nei casi dubbi di colecistite acuta o di discrepanza clinico-ecografica oppure nelle forme complicate. Cattedra di Radiologia. The qualitative evaluation of cardiac iron deposition was useful for an easier classification of the disease, bypassing the SI quantitative value which is affected by the extremely uneven distribution of iron deposition and by the sampling technique used. MR evaluation of non-cardiopatic thalassaemic patients may be useful to evaluate early iron deposition and to establish the most suitable chelation therapy. Nei pazienti talassemici sono stati considerati i valori di ferritina sierica e, con esame ecocardiografico, la frazione di eiezione del ventricolo sinistro. In tutti i casi, utilizzando una ROI di dimensioni adeguate, sono stete calcolate l'intensita' di segnale SI del miocardio e del muscolo scheletrico, il rapporto d'intensita' di segnale SIR miocardio. Directory of Open Access Journals Sweden. Risultati : il campione è stato rappresentato da 62 soggetti 35 uomini e 27 donne, età media di 39,40 anni. I risultati hanno dimostrato la necessità per gli studi di valutazione della qualità percepita di adottare i metodi e gli strumenti della ricerca. Interruzione del trattamento nei pazienti con schizofrenia che ricevono olanzapina o aripiprazolo: metanalisi degli studi clinici controllati. The drop-out evaluation is also important considering the relevant economic impact for NHS of an antipsychotic therapy discontinuation in terms of patient hospitalization and other related healthcare resources consumption. Analysis included 12 randomized controlled trials 3. RCT inclusion criteria were: a Patients affected by schizophrenia; b Randomized assignment to olanzapine or aripiprazole treatment group; c Number of patients included in the treatment group higher than ; d Drop-out frequency evaluation between 4th and 26th weeks of follow-up. The comparison between drop-out percentages is statistically significant p CE-Magnetic Resonance mammography for the evaluation of the contralateral breast in patients with diagnosed breast cancer; Ruolo della Risonanza Magnetica con Gd-BOPTA nella valutazione della mammella controlaterale in pazienti con tumore recentemente diagnosticato. Dipartimento di scienze chirurgiche. To evaluate the role of contrast-enhanced Magnetic Resonance Mammography MRM in the evaluation of the contralateral breast in patients with recently diagnosed breast cancer. Materials and methods. Fifty patients with proved unilateral breast cancer, with a negative contralateral breast at physical examination, ultrasound and mammography, were studied with a 1. A bilateral breast surface coil was used. Dynamic 3D Flash T1-weighted sequences were acquired in the axial plane before and 0, 2, 4, 6 and 8 minutes after the administration of 0. The level of suspicion was reported on a scale from 0 to 5 following the BI-RADS classification, based on lesion morphology and kinetic features. The results were compared with the histological findings after biopsy or surgery. Histology diagnosed three fibroadenomas, 5 ductal carcinoma in situ, 2 lobular carcinomas in situ, 3 invasive ductal carcinomas and 1 invasive lobular carcinoma. Contrast enhanced MRM yielded no false negative and three false positives. Our results demonstrate a very good accuracy of Magnetic Resonance Mammography in the detection of synchronous contralateral cancer in patients with newly diagnosed breast cancer. Therefore, contrast-enhanced MRM could be introduced to screen patients with proven breast cancer before they under-go surgery. Definire il ruolo della Risonanza Magnetica nella valutazione della mammella contro laterale in pazienti con tumore della mammella recentemente diagnosticato. Cinquanta pazienti con tumore monolaterale della mammella e mammella controlaterale. Polimorfismi nei geni metabolici come fattori dirischio per il carcinoma gastrico GC: risultati preliminari di uno studio caso-controllo. Risultati : le frequenze dei polimorfismi nei geni metabolici sono risultate in alcuni casi differenti nei casi rispetto ai controlli sebbene non si evidenzi una differenza statisticamente significativa. In particolare il genotipo GSMT1 null è più elevato nei pazienti rispetto ai controlli Conclusioni : i risultati preliminari di questo studio evidenziano associazioni tra alcuni genotipi metabolici e parametri clinico-patologici, che se confermati potrebbero permettere di identificare sottogruppi con prognosi più sfavorevole di GC da indirizzare preventivamente verso trattamenti specifici. Valutazione del carico di stress nei Vigili del Fuoco: correlazione con il profilo psicologico ed alcuni indicatori biologici di rischio. Un sottogruppo di vigili ha fornito anche un campione di saliva dopo un turno lavorativo notturno condizione di stress. Conclusioni : i Vigili del Fuoco sono risultati meno ansiosi, più predisposti al rischio e con un profilo di personalità di tipo realistico in linea con la scelta professionale. CF findings of bowel infarction in 56 surgical patients, 5 of whom with reversible ischemia; Aspetti alla tomografia computerizzata dell'infarto intestinale. Salzano, A. Cardarelli, Naples Italy. Servizio di Neuroradiologia. Diagnosis on often late because clinical signs, laboratory data and radiologic findings are a specific. The authors investigated radiographic and particular CT patterns of intestinal infraction in 56 patients submitted to surgery within 12 hours of admission. We also report the CT findings of 5 of these patients who had reversible mesenteric ischemia. CT is more sensitive than radiography and does not exhibit the limitations of angiography i. Therefore CT can presently be considered the method of choice in patients with suspected bowel infarction. Il riconoscimento diagnostico e' tardivo per l'aspecificita' dei dati di laboratorio, dei segni clinici e degli esami radiologici. La TC presenta maggiore afficacia diagnostica rispetto all'esame radiografico diretto e non ha limiti che caratterizzano l'angiografia, quali l'invasivita', radioesposizione e complessita' organizzativa: attualmente la metodica TC puo' essere indicata come indagine di scelta in pazienti con sospetto infarto intestinale. Istituto di Radiologia. Conclusions: Vasoseal ES is a safe collagen device characterized by a high success rate. In anticoagulated patients the device can reduce the time to mobilisation and the incidence of complications. Materiale e metodi: Tra gennaio e marzo sono stati seseguiti accessi arteriosi transfemorali consecutivi in pazienti in 11 pazienti e' stato effettuato un accesso bilaterale sottoposti a procedure radiologiche vascolari: angioplastiche PTA e 40 chemioembolizzazioni TACE. Gli introduttori sono stati rimossi al termine delle manovre interventistiche e sulla superficie esterna dell'arteria sono state posizionate 2 cartucce di collagene; i valori medi di PTS e PTT erano rispettivamente Il giorno successivo e' stato effettuato uno studio ecografico con tecnica color-Doppler nel sito di puntura. Il tempo. Medline Plus. Full Text Available NEI is a national database of air NEI for Kids: Glossary. Emily Y. Chew, M. Radiodine treatment of hyperthyroidism with a simplified dosimetric approach. Clinical results; Terapia radiometabolica dell'ipertiroidismo con approccio dosimetrico semplificato. Risultati clinici. Giovanella, L. Cattedra di Medicina Nucleare, Ist. Tale attivita' minima e' stata quindi modulata in base ai dati clinici, laboratoristici e strumentali fino all'attivita' massima intra-tiroidea di MBq dopo 24 ore. I pazienti sono stati sottoposti a controllo clinico e laboristico 3 e 12 mesi dopo il trattamento, instaurando l'opportuna terapia tireo-sostitutiva nei casi di ipotiroidismo. Nei pazienti affetti da mrobo di Graves-Basedow e' stata somministrata una attivita' media di MBq distribuzione: MBq. Tre pazienti sono stati immediatamente sottoposti a secondo trattamento con radioiodio mentre 32 pazienti ipotiroidei hanno iniziato la terapia tireo-sostitutiva. Il risultato definitivo dopo 12 mesi e' stato di risoluzione del quadro di abstract truncated. Evoluzione dell' abitudine al fumo nei locali dellíAzienda Ospedaliera Universitaria Senese dal al Questo studio è stato ripetuto negli anni , e Conclusioni : la diminuzione costante del numero di fumatori in ospedale, mostra come ci sia stato negli ultimi anni un rispetto sempre maggiore del divieto di fumo nei luoghi di cura. Il coinvolgimento di futuri medici permette di promuovere il problema fumo in ospedale. Ferrando, R. Genua Italy. Per la defecografia tradizionale si e' utilizzato un apparecchio telecomandato e valutato le quattro fasi di: riposo, trattenimento, ponzamento e spinta. Per lo studio con TC e' stata eseguita acquisizione volumetrica spirale con collimazione del fascio di 5 mm, pitch 2, kV, m As e inclinazione del tunnel di scansione di gradi verso il paziente al fine di ottenere piani coronali del pavimento pelvico. Il paziente dotato di pannolone per adulti e' posizionato a cavalcioni del tavolo porta-paziente in posizione da motociclista, previa distensione dell'ampolla rettale con bolo fecale costituito da ml di mdc iodato non ionico con la diluizione di 3 g di iodio per ml. L'esame e' stato eseguito nella posizione supina nei casi nei quali i pazienti non riuscivano a mantenere la posizione. E' stata eseguita acquisizione volumetrica spirale di 20 secondi nella fase di riposo e di spinta con ricostruzioni multiplanari specie sul piano sagittale per il confronto con le immagini con la defecografia tradizionale. La defeco-TC ha consentito di evidenziare malattie estrinseche all'apparato ano-rettale, risultando esame di seconda istanza rispetto alla defecografia tradizionale ma dirimente nei casi dubbi per la possibilita' di valutare il trofismo dei muscoli deputati all'atto defecatorio e le strutture contigue attraverso le ricostruzioni multiplanari con alta risoluzione. Communication dustin. DeMott nih. Technical questions about this website Technical questions about this Technical questions about this website can be addressed MR study of the intrinsic acromial angle in 74 symptomatic patients; Studio RM dell'angolo intrinseco dell'acromion in 74 pazienti sintomatici. Servizio di radiologia. These parameters were found to be consistent and comparable with tue Bigliani classification of acromial morphology which, although providing useful qualitative data, does not fully respond to our quantitative needs. Our study suggests that impingement syndrome is negatively correlated to acromio-humeral distance and positively correlated to intrinsic acromial angle. These parameters, which are readily detected with MRI, may be used by the radiologist and orthopaedic surgeon to screen patients with nonspecific impingement syndrome. Lo scopo e stato quello di individuare un piano di scansione con alcune misurazioni associate che fornissero delle indicazioni quantitative sullo spazio subacromiale nei pazienti affetti di sindrome da impingement aspecifica. Settantaquattro pazienti 47 maschi, 27 femmine, eta compresa tra 35 e 62 anni che presentavano una sintomatologia da sospetta sindrome da impingement sono stati sottoposti al nostro studio. E stata adottata la classificazione di Bigliani per la morfologia dell'acromion confrontata con il nostro metodo di misura basato sulla rilevazione del valore espresso in gradi dell'angolo intrinseco dell'acromion e sulla misura della distanza acromion-omerale. I dati ricavati del valore dell'angolo risultano correlati alla classificazione di Bigliani. Nelle rotture parziali. This website is maintained by the Hays - Chief, Science Communication dustin. Caratterizzazione della flora microbica orale in diverse categorie di pazienti sindromici in età evolutiva. Ricerche sperimentali e cliniche hanno individuato i momenti eziopatogenetici delle diverse problematiche che si riscontrano a carico del cavo orale, con una frequenza superiore nei paz This website is DeMott, Media Relations Kathryn. Apple, Amazon, Google y Facebook pagan sólo 22 millones a Hacienda. Bélgica ha establecido una compensación para el trabajador de ,48 euros al mes. Foto: Dreamstime. Ignacio Faes Javier Calvo. Teletrabajo Coronavirus Europa Trabajadores Empresas. Comparte esta noticia..

Así, si lo hacen un día a la semana el pago es de 10 euros mensuales, si lo hacen dos días a la semana es de 20 euros Vittorio colao esposa disfunción sexual En Suiza no hay una legislación que establezca una compensación para los trabajadores que realicen su función desde casa. Pero una reciente sentencia de un Tribunal Federal, recogida por RTS, ha obligado a una empresa a pagar a un Vittorio colao esposa disfunción sexual al que obligó a teletrabajarfijando una indemnización de francos suizos unos euros al mes.

Por su parte, Alemania lleva trabajando en el desarrollo de su normativa sobre el teletrabajo desde this web page, como anunció su ministro de Trabajo, Hubertus Heil, que quiere que los trabajadores puedan seguir trabajando a distancia tras la pandemia.

Apenas existe legislación sobre este asunto. Sin embargo, es sólo un preliminar marco jurídico, con muchos aspectos que deben ser precisados en una regulación posterior. Mapa web.

Todos los derechos reservados. Christina aguilera topless hd. Ruolo delle nuove tecnologie basate sugli ultrasuoni nella valutazione dell'ipertensione portale nei pazienti con epatopatia cronica. Orsola-Malpighi, Bologna Italy.

UO Radiologia d' urgenza, Dipartimento emergenze ed accettazione. Materiale e metodi. Abbiamo valutato i risultati di 72 biopsie ripetute in pazienti con una diagnosi di PIN ad una prima agobiopsia prostatica ecoguidata. A tutti e stato effettuato un numero minimo di 6 prelievi. I risultati sembrano confermare che il PIN puo essere considerato un precursore dell'adenocarcinoma prostatico o un'alterazione istologica frequentemente associata ad esso.

I pazienti con diagnosi iniziale di PIN a basso grado e soprattutto quelli con PIN ad alto grado dovrebbero sistematicamente essere sottoposti a biopsia ripetuta a breve distanza per l'elevata frequenza di diagnosi finale di carcinoma.

Non esistono ancora indicazioni condivise sull'intervallo temporale tra le due biopsie. Le more info del PSA che si possono riscontrare durante il periodo di osservazione non rappresentano un parametro statisticamente significativo per proporre o meno al Vittorio colao esposa disfunción sexual la ripetizione della biopsia prostatica. Hemodynamic effects of a prostacyclin analog Prostavasin in systemic sclero-derma patients; Effetti di un analogo della prostaciclina Prostavasin sui parametri Doppler nei pazienti con sclerodermia.

Politecnica delle Marche, Ancona Italy. Istituto di radiologia. Il gruppo di studio GS e composto da 50 pazienti affetti da sclerodermia con anamnesi negativa per malattie cerebrovascolari, epatopatie, nefropatie e oftalmopatie. In tutti i pazienti e stata studiata la vasodilatazione endotelio-mediata dell'arteria brachiale tramite la misurazione del diametro trasverso con sonda ad alta risoluzione; sono stati anche misurati l'indice di resistenza IR delle arterie cerebrale media, centroretinica, epatica propria, mesenterica superiore e renali, in condizioni read article e dopo tre giorni di terapia.

AI fine di valutare la variabilita intra-osservatore delle misurazioni, e stato reclutato un gruppo di controllo GC composto da 10 volontari sani che sono stati studiati con il medesimo protocollo Doppler e rivalutati a Vittorio colao esposa disfunción sexual di tre giorni senza ricevere alcuna terapia. Il GS ha dimostrato un significativo incremento della dilatazione endotelio-mediata dell'arteria brachiale, del diametro e della velocita media di flusso portale, dell'IP dell'arteria splenica all'ilo pre-Prostavasin vs post-Prostavasin, p pazienti del GS pur non risultando statisticamente significativi.

Nel campione esaminato il Prostavasin ha dimostrato una potente azione vasodilatatoria prevalentemente a livello periferico ed ha Vittorio colao esposa disfunción sexual la velocita media di flusso portale ed il diametro della Vittorio colao esposa disfunción sexual porta, ma anche l'IP dell'arteria splenica all'ilo, non supportando l'ipotesi formulata da altri autori di una sua azione mirata e specifica sulle resistenze intraepatiche.

Gisonni, P. Federico 2. L'identificazione del miocardio malfunzionante ma ancora vitale ha particolare rilevanza nel predire il recupero della funzione ventricolare in seguito a interventi di rivascolarizzazione coronarica. Relationship between exercise capacity and left ventricular function at rest in Vittorio colao esposa disfunción sexual with heart failure.

An ambulatory left ventricular monitoring study; Relazione tra capacita' di esercizio e funzione ventricolare sinistra a riposo nei pazienti con insufficienza cardiaca.

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Studio mediante Vittorio colao esposa disfunción sexual continuo radionuclidico della funzione ventricolare sinistra. Pace, L. Medicina Nucleare; Romano, M. Medicina Interna. Purpose of this work is to evaluate the relationship of systolic and diastolic function at rest to Vittorio colao esposa disfunción sexual capacity. Article source patients with ischemic heart failure were included in the study.

Ambulatory left ventricular monitoring at rest and during upright exercise with combined analysis of pulmonary gas exchange was performed. Ejection fraction, end-diastolic volume, end-systolic volume, stroke volume, cardiac output, and peak filling rate were measured. Sono stati studiati 17 pazienti con insufficienza cardiaca di origine ischemica.

Tutti sono stati sottoposti a monitoraggio radionuclidico continuo della funzione ventricolare sinistra in combinazione con. Vittorio colao esposa disfunción sexual laser photocoagulation in the treatment of liver tumors.

Personal technique, short term results and complications in patients with normal and impaired liver function; Fotocoagulazione laser-interstiziale ecoguidata dei tumori maligni del fegato: see more personale, risultati immediati e complicanze a breve termine nei pazienti con funzionalita' epatica normale e alterata.

Giorgio, A. Cotugno, Vittorio colao esposa disfunción sexual Italy. Servizio di Ecografia ed Ecointerventistica; Catalano, O. Servizio di Radiologia; Alalia, A.

II, Naples Italy. The work reports the personal experience with interstitial laser photocoagulation in patients with liver tumors mostly cirrhotics with hepatocellular carcinoma. The aim was to evaluate the short term efficacy of percutaneous interstitial laser photocoagulation in inducing focal ablation of liver tumors and the possible complications in patients with normal and impaired liver function.

Lo scopo e' quello di verificare l'efficacia terapeutica in termini di volume di necrosi e di valutare gli effetti collaterali e le complicanze a breve termine sulla riserva funzionale del fegato e di altri organi, soprattutto nei pazienti con alterata funzionalita' epatica. Ricerca clinico-epidemiologica sullo stato di salute del cavo orale nei pazienti tossicodipendenti. Obiettivo: Lo scopo della ricerca è stato quello di mettere in evidenza la presenza di patologie del cavo orale in soggetti tossicodipendenti Materiali e Metodi: Sono stati reclutati 71 pazienti in terapia di recupero presso la Comunità Incontro di Amelia.

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I soggetti sono stati sottoposti a visite clinico-anamnestiche adottando una cartella clinica da noi stessi costruita. Risultati: Dei 71 soggetti tossicodipendenti, 42 facevano uso di eroina e 39 assumevano droghe per v Personal experience on 71 consecutive patients with acute cholecystitis; Esperienza personale in settantuno pazienti consecutivi con colecistite acuta.

Vittorio colao esposa disfunción sexual, A. Cardarelli, Neaples Italy. Federico 2, Neaples Italy. Nell'arco di tempo di 16 mesi, 71 pazienti consecutivi 42 femmine e 29 maschi con eta' compresa tra 34 e 84 anni, eta' media 58 anni con sintomatologia addominale acuta sono stati operati per colecistite acuta presso l'Azienda Ospedaliera A.

Cardarelli di Napoli. L' esame diretto dell'addome e' stato eseguito in 65 casi su Vittorio colao esposa disfunción sexual, l'ecografia addominale in 69 e la TC in 6.

All'esame TC dell'addome sono stati ricercati: distensione della colecisti, Vittorio colao esposa disfunción sexual delle pareti colecistiche, contenuto endocolecistico, liquido pericolecistico e alterazioni di tipo infiammatorio nel grasso pericolecistico. L'ecografia rappresenta la metodica di scelta nello studio della colecistite acuta giacche' consente nella maggioranza dei casi di formulare la diagnosi definitiva.

La TC riveste un ruolo trascurabile nella valutazione iniziale dei pazienti con colecistite acuta. Essa puo' essere utile nei casi dubbi di colecistite acuta o di discrepanza clinico-ecografica oppure nelle forme complicate. Cattedra di Radiologia. The qualitative evaluation of cardiac iron deposition was useful for an easier classification of the disease, learn more here the SI quantitative Vittorio colao esposa disfunción sexual which is affected by the extremely uneven distribution of iron deposition and by the sampling technique used.

MR evaluation of non-cardiopatic thalassaemic patients may be useful to evaluate early iron deposition and to establish the most suitable Vittorio colao esposa disfunción sexual therapy.

Nei pazienti talassemici sono stati considerati i valori di ferritina sierica e, con esame ecocardiografico, la frazione di eiezione del ventricolo sinistro. In tutti i casi, utilizzando una ROI di dimensioni adeguate, sono stete calcolate l'intensita' di segnale SI del miocardio e del muscolo scheletrico, il rapporto d'intensita' di segnale SIR miocardio.

Directory of Open Vittorio colao esposa disfunción sexual Journals Sweden. Risultati : il campione è stato link da 62 soggetti 35 uomini e 27 donne, età media di 39,40 source. I risultati source dimostrato la necessità per gli studi di valutazione della qualità percepita di adottare Vittorio colao esposa disfunción sexual metodi e gli strumenti della ricerca.

Interruzione del trattamento nei pazienti con schizofrenia che ricevono olanzapina o aripiprazolo: metanalisi degli studi clinici controllati. The drop-out evaluation is also important considering the relevant economic impact for NHS of an antipsychotic therapy discontinuation in terms of patient hospitalization and other related healthcare resources consumption. Analysis included 12 randomized controlled trials 3. RCT inclusion criteria were: a Patients affected by schizophrenia; b Randomized assignment to olanzapine or aripiprazole treatment group; c Number of patients included in the treatment group higher click ; d Drop-out frequency evaluation between 4th and 26th weeks of follow-up.

The comparison between drop-out percentages is statistically significant p CE-Magnetic Resonance mammography for the evaluation of the contralateral breast in patients with diagnosed breast cancer; Ruolo della Risonanza Magnetica con Gd-BOPTA nella valutazione della mammella controlaterale in pazienti con tumore recentemente diagnosticato. Dipartimento di scienze chirurgiche. To evaluate the role of contrast-enhanced Magnetic Resonance Mammography MRM in the evaluation of the contralateral breast in patients with recently diagnosed breast cancer.

Materials and methods. Fifty patients with proved unilateral breast cancer, with a negative contralateral breast at physical examination, ultrasound and mammography, were studied with a 1. A bilateral breast surface coil was used. Dynamic 3D Flash T1-weighted sequences were acquired in the axial plane before and 0, 2, 4, 6 and 8 minutes after the administration of 0.

The level of suspicion was reported on a scale from 0 to 5 following the BI-RADS classification, based on lesion morphology and kinetic features.

Nuremberg sex Watch Porn Movies Yakima sex. Desde principios de Abril, las. El Gobierno de México no aplica pruebas masivas a la población y calcula, mediante un modelo de. El esposo de la hoy occisa viajó a Tijuana y a su retorno la contagió. Hasta el momento, se tiene registrado que alrededor de 10 familiares también fueron contagiados y casi una treintena entre enfermeras y médicos se encuentra en confinamiento domiciliario hasta por quince días. En conferencia de prensa. Expuso que en la Ciudad de México hay 2 mil confirmados con Covid; intubados se tienen registradas personas; y hospitalizadas, mil Expuso que Locatel, a través de los mensajes SMS, ha atendido El equipo científico que llevó a cabo la investigación dio a conocer en un comunicado de prensa que, tras analizar 10 casos de introducción del virus al país, fue posible determinar y corroborar que la mayor parte de dichas introducciones vienen de diferentes regiones de Europa. Los cambios identificados en los genomas definen la circulación en el país de dos de los tres genotipos reportados hasta ahora, el linaje A también llamado G y el linaje B. Fue, pues, un periodismo militante de una causa. Los hermanos Flores Magón usaron su periódico Regeneración como espacio militante en la lucha del Partido Liberal contra Díaz, padrino de bautizo, por cierto, de uno de ellos; por lo tanto, se trató de un periodismo parcial, partidista, excluyente, ideológico y. Y contrarios a su proyecto enlistó a los mismos periodistas criticados en las conferencias matutinas. El estilo es el sello del hombre Goethe , dedicado a resaltar, sin embargar adjetivos, la figura de Echeverría. Si el Presidente quiere solo leer, escuchar o ver medios y periodistas que hagan de sus comparsas, como los personajes que le ponen en sus conferencias mañaneras, también puede tenerlos, como de hecho los tiene. Mientras, en España. Política para dummies: La política es el antídoto al autoritarismo; bueno, debiera ser. No soy de los periodistas que se toman las cosas personales ni me gusta escribir sobre polémicas o debates, y menos con el Presidente, pero ese estilo inédito de atacar a todo mundo desde la Presidencia y ese nivel de intolerancia a la crítica, obligan a decirle a quien hoy nos gobierna a todos los mexicanos que se serene y que entienda que ya no es el líder social que arenga desde el mitin o la plaza; que hoy tiene una investidura que debe enaltecer no envilecer y una tribuna que le da todo el poder y cada palabra suya, cada descalificación y comentario negativo sobre cualquier mexicano, institución o empresa tiene un efecto brutal. Aquí seguiremos para contar lo que suceda en este país y en su Gobierno, con la libertad que nos otorga la Constitución y con la responsabilidad, el rigor y la ética que nos exige nuestra profesión. En esa calidad es que los medios y los periodistas le analizamos y lo criticamos, como el poder que representa, porque la esencia y la razón de ser de la libertad de prensa es criticar y cuestionar al poder. Tal vez algunos periodistas militantes y convencidos de su proyecto u otros mercenarios y acomodaticios, lo vean y lo analicen de esa manera, pero no todos podemos verlo como él exige, con los ojos de la fe y la convicción política. Me ha tocado criticar, comentar y cuestionar, desde este espacio, las acciones, dichos y decisiones. Siendo estas las primeras mascotas en contraer la enfermedad. Sin embargo, no es la primera vez que se detecta el virus en animales, ya que a inicios de Abril se informó también que una tigresa del Zoológico de Brons, en esa misma ciudad estadounidense, junto con otros cinco tigres dieron positivo a Covid 19, al observar que tenían dificultad para respirar. Esta situación, ha desatado dudas e inquietudes entre la población que a diario consume información sobre la pandemia que mantiene a la población mundial confinada, y en el aislamiento social, y que ahora podría afectar también la convivencia con mascotas. Por lo pronto el Centro de Prevención y Enfermedades de Estados Unidos, ha reiterado que no hay evidencia por el momento, que compruebe que las mascotas jueguen un rol activo en la propagación del Covid Mientras que la Organización Mundial de la Salud advierte que la transmisión directa entre seres humanos es el principal factor de propagación del Coronavirus. Este tema, también ha generado la propagación de información falsa en redes sociales. Mientras tanto el miedo crece entre la población en todo el mundo por la pandemia, ya que, ha sido difícil mantener un control en la propagación de Covid Coronavirus entre los seres humanos, tener un control sobre los animales sería casi imposible, sobre todo si se empieza a detectar la enfermedad en otros animales que a diario tienen contacto con los seres humanos. Por lo pronto en México, la recomendación de las autoridades de salud es extremar precauciones cuando se mantiene un contacto directo con las mascotas. Cerco de Seguridad da Resultados. Corporaciones de seguridad de los tres niveles de Gobierno mantienen un cerco de seguridad que ha mantenido a raya a la delincuencia. En días pasados, en el marco de una video conferencia, el mandatario estatal precisó que se han diseñado estrategias para evitar saqueos y que, a través de la. Coronavirus en Animales Policía Cibernética se ha detenido a personas que incitan en redes sociales a realizarlos. Igualmente, dijo, se refuerzan las tareas que combaten y previenen la violencia intrafamiliar. En materia migratoria, mencionó que el trabajo encabezado por el secretario de Relaciones Exteriores, Marcelo Ebrard Casaubón, ha permitido que los países de Centroamérica abran las fronteras y reciban a sus connacionales; refirió que ha. Tras destacar el respaldo de la Federación al Estado de Chiapas, señaló que el Ejército Mexicano colabora arduamente en el resguardo de las clínicas alternas que atienden casos de COVID, asimismo, enfatizó. Las acciones de seguridad y prevención en apoyo a la población durante esta contingencia han sido diversas. Por hoy ahí la dejamos, nos leemos mañana. Comentarios y denuncias: loque46 hotmail. El decreto del 21 de Abril anunciado por el Presidente se compromete a sostener los mismos programas sociales anunciados por él desde su toma de posesión. Los recursos destinados a estos rubros estaban asignados previamente a la pandemia y los padrones de beneficiarios se levantaron mucho antes de que el Coronavirus comenzara a hacer estragos en China. Ciertamente, el decreto del 21 de Abril no crece los programas ni tampoco el padrón de sus. Manifestó que, para hacer frente a esta tercera fase del mortal virus, Chiapas se ha preparado con clínicas alternas en municipios estratégicos; buscando con ello atender, controlar y cortar la cadena de contagio. Por otro lado, muchos de los habitantes del Soconusco se mantienen con el alma en un hilo, debido a que hasta ahora, debido al esfuerzo de las autoridades de los tres niveles de Gobierno,. Alfil Negro 97 Contagiados en Chiapas así como por la gracia y el poder de Dios, esta región fronteriza no se ha convertido en el foco de la pandemia en el sur de México. Podría decirse que la medicina se concibió antes de la enfermedad. Se trata de un conjunto de medidas destinadas a un problema que, aunque parecería similar, es en realidad muy distinto. Por tanto, los apoyos y sobre todo el padrón de beneficiarios tendrían también que ampliarse. Y el Presidente tiene la obligación. La administración lopezobradorista cuenta con la opción de crecer el padrón de beneficiarios de sus programas sociales. Sería sin duda una opción congruente. Esto obligaría a la Secretaría del Bienestar a trabajar de nuevo en el padrón de las personas atendidas por el Gobierno Federal. Otra opción, pensando fuera de la caja, sería aprovechar la circunstancia para dar el giro final que le hace falta a la política social mexicana. La ocasión lo amerita y legitima. Un seguro que, al menos durante seis meses, permita a las madres y padres de familia paliar la situación de sus hijos y familiares. Este es el comparativo de defunciones por entidad federativa en el país. Chiapas llega a las 6 pérdidas de vida. Fuente: Ssa. Durante su participación, el. El auditor superior del Estado, José Uriel Estrada Martínez, manifestó su disponibilidad de asesorar a las y los Presidentes Municipales, en el manejo de los recursos y la realización de los proyectos de aportación correspondientes a los fondos antes mencionados. Especialidad Teléfono Celular Central Sur No. Promoción Especial a Profesores Previa identificación Se aceptan tarjetas de crédito Visa Mastercad 6 y 12 mensualidades sin intereses. Avenida Sur No. Norte No. Magazine Médico? Pregunta quién te atendió. A P. Y P. El culpable se identificó como Policía de la Guardia Nacional y se portó bastante agresivo, tanto con los propietarios afectados como con los vecinos. Se presentó el ajustador de la compañía de seguros del repartidor de gas y se comprometió a cubrir los daños causados por su cliente. La autoridad comprobó que se encontraba en estado de ebriedad y al negarse a cubrir los daños, fue asegurado y puesto a disposición de las autoridades del Fiscal de Juicios Orales. Al sitio acudió el ajustador de la compañía de seguro del responsable y se comprometió a cubrir los daños causados. Sur, no hizo el alto total y al cruzar se impactó contra una motocicleta Italika FT de color negro con rojo, que venía de Sur a Norte. El motociclista resultó con algunas lesiones, varios conductores lo auxiliaron y vía telefónica solicitaron la presencia de las autoridades policiacas para que realizaran las primeras diligencias correspondientes. El accidente sería turnado ante las autoridades competentes Extraviadas en el tramo y los vehículos fueron Tapachula-Puerto Madero. Mesa de Redacción De acuerdo a las investigaciones por parte del gerente de la empresa transnacional, se detectaron varios faltantes de dinero. Ante estos hechos se presentó la denuncia ante las autoridades ministeriales, para que inicien las. Ante estos hechos iniciaron una carpeta de investigación para detener a la persona responsable. Mesa de Redacción. Te invitamos a seguir las indicaciones para salvaguardar tu bienestar. Norte esquina 5a. Six lots 8. Four FBS batches 5. Five batches 6. The high frequency of contamination of FBS with pestivirus RNA reinforce the need for systematic and updated guidelines for monitoring this product to reduce the risk of contamination of biologicals and introduction of contaminating agents into free areas. Recombinant pestivirus E2 glycoproteins prevent viral attachment to permissive and non permissive cells with different efficiency. Bovine viral diarrhoea virus BVDV is an economically important animal pathogen, which like other pestiviruses has similar molecular biological features to hepaciviruses, including human Hepatitis C virus. The pestivirus E2 glycoproteins are the major target for virus-neutralising antibodies, as well as playing a role in receptor binding and host range restriction. In this study, recombinant E2 glycoproteins rE2 derived from three different pestivirus species were examined for their inhibitory effects on pestivirus infectivity in cell culture. The ability of rE2 glycoprotein to inhibit the infection of permissive cells by both homologous and heterologous virus was compared, revealing that the inhibitory effects of rE2 glycoproteins correlated with the predicted similarity of the E2 structures in the recombinant protein and the test virus. This result suggests that the sequence and structure of E2 are likely to be involved in the host specificity of pestiviruses at their point of uptake into cells. Genomic and antigenic relationships between two 'HoBi'-like strains and other members of the Pestivirus genus. To date, few complete genome sequences of 'HoBi'-like viruses are available in public databases. Moreover, detailed analyses of such genomes are still scarce. In an attempt to expand data on the genetic diversity and biology of pestiviruses , two genomes of 'HoBi'-like viruses recovered from Brazilian cattle were described and characterized in this study. Analysis of the whole genome and antigenic properties of these two new 'HoBi'-like isolates suggest that these viruses are genetically close to recognized pestiviruses. The present data provide evidence that 'HoBi'-like viruses are members of the genus Pestivirus and should be formally recognized as a novel species. The viral envelope is not sufficient to transfer the unique broad cell tropism of Bungowannah virus to a related pestivirus. Bungowannah virus is the most divergent pestivirus , and both origin and reservoir host have not been identified so far. We therefore performed in vitro tropism studies, which showed that Bungowannah virus differs remarkably from other pestiviruses. Interestingly, cell lines of vervet monkey, mouse, human and even of bat origin were susceptible. This broad in vitro tropism was not observed for a chimeric bovine viral diarrhoea virus BVDV expressing all structural proteins of Bungowannah virus. The viral envelope was not sufficient to completely transfer the cell tropism of Bungowannah virus to another pestivirus , and viral RNA replication was either markedly reduced or not detectable in a number of different cell lines for the tested BVDV strain and the chimera. We therefore suggest that the replication machinery together with the viral envelope is responsible for the unique broad cell tropism of Bungowannah virus. Numerical taxonomy of the genus Pestivirus : new software for genotyping based on the palindromic nucleotide substitutions method. Pestivirus identification using PNS was evaluated on five hundred and forty-three sequences at genus, species and genotype level using this software. The software is freely available at www. A serosurvey for ruminant pestivirus exposure conducted using cattle sera collected for brucellosis surveillance in the United States. Four species of ruminant pestivirus are currently circulating in the United States: Bovine viral diarrhea virus 1 and 2 BVDV-1, -2; predominant host: cattle , Border disease virus BDV; predominant host: sheep , and pronghorn virus sporadically detected in wild ruminants. A third bovine pestivirus called HoBi-like virus has been detected in cattle and water buffalo in South America, Asia, and Europe. To date, no isolations of HoBi-like viruses from U. To assess exposure, 2, cattle sera, collected between and as part of the U. In addition, RNA was extracted and tested by reverse transcription-polymerase chain reaction for the presence of pestiviruses ; all samples tested negative. The percent of VN-positive samples was Because the 3 bovine pestiviruses are antigenically cross-reactive, the comparative level of antibody against each pestivirus species was determined. Based on comparative titers, samples were segregated into 6 categories: no titers 7. X-ray structure of the pestivirus NS3 helicase and its conformation in solution. Pestiviruses form a genus in the Flaviviridae family of small enveloped viruses with a positive-sense single-stranded RNA genome. Viral replication in this family requires the activity of a superfamily 2 RNA helicase contained in the C-terminal domain of nonstructural protein 3 NS3. The structure deviates significantly from that of NS3 of other genera in the Flaviviridae family in D3, as it contains two important insertions that result in a narrower nucleic acid binding groove. We also show that mutations in pNS3h that rescue viruses from which the core protein is deleted map to D3, suggesting that this domain may be involved in interactions that facilitate particle assembly. Finally, structural comparisons of the enzyme in different crystalline environments, together with the findings of small-angle X-ray-scattering studies in solution, show that D2 is mobile with respect to the rest of the enzyme, oscillating between closed and open conformations. Binding of a nonhydrolyzable ATP analog locks pNS3h in a conformation that is more compact than the closest apo-form in our crystals. Together, our results provide new insight and bring up new questions about pNS3h function during pestivirus replication. Although pestivirus infections impose an important toll on the livestock industry worldwide, little information is available about the nonstructural proteins essential for viral replication, such as the NS3 helicase. We provide here a comparative structural and functional analysis of pNS3h with respect to its orthologs in other viruses of the same family, the flaviviruses and hepatitis C virus. Our studies reveal differences in the nucleic acid binding groove that could have implications for understanding the. In this study, we report the first complete nucleotide sequence of BDV, that of strain X The genome is 12, nucleotides long and contains one long open reading frame encoding 3, amino acids. Comparison of the deduced amino acid sequence of X with the ones of other pestiviruses allowed the prediction of polyprotein cleavage sites which were conserved with regard to the structural proteins. Tautz, K. Elbers, D. Stoll, G. Meyers, and H. Thiel, J. Xu, E. Mendez, P. Caron, C. Lin, M. Murcko, M. Collett, and C. Rice, J. Evaluation of envelope glycoprotein E rns of an atypical bovine pestivirus as antigen in a microsphere immunoassay for the detection of antibodies against bovine viral diarrhea virus 1 and atypical bovine pestivirus. Atypical bovine pestiviruses are related antigenically and phylogenetically to bovine viral diarrhea viruses BVDV-1 and BVDV-2 , and may cause the same clinical manifestations in animals. The recombinant E rns protein was used as an antigen in a microsphere immunoassay for the detection of antibodies against BVDV-1 and atypical bovine pestivirus. The diagnostic performance of the new method was evaluated by testing a total of serum samples, and the assay was compared with enzyme-linked immunosorbent assay ELISA. The immunoassay was able to detect antibodies against both BVDV-1 and the atypical pestivirus. This novel microsphere immunoassay has the potential to be multiplexed for simultaneous detection of antibodies against different bovine pathogens in a high-throughput and economical way. Temporal dynamics of 'HoBi'-like pestivirus quasispecies in persistently infected calves generated under experimental conditions. Pestivirus strains exist as quasispecies swarms of individual viruses in infected animals and the viral populations making up the quasispecies differ widely in size and diversity in each animal. In the present study the viral quasispecies circulating in persistently infected PI calves, generated and maintained under experimental conditions using two different 'HoBi'-like strains, was observed over time. An increase in genetic variability and the development of certain mutations was observed over time. It is hypothesized that these changes may be the results on continued adaption of the pestivirus to individual hosts. This is the first study characterizing variation in the viral swarms of animals persistently infected with HoBi-like viruses over time. Studies of the shifts in PI viral swarms will contribute to our understanding of the host and viral mechanisms that function in the maintenance of pestivirus persistent infections. Circulating immune cell subpopulations in pestivirus persistently infected calves and non-infected calves varying in immune status. Circulating immune cell subpopulations in cattle representing varying stages of immune status categorized as; colostrum deprived CD , receiving colostrum COL , colostrum plus vaccination VAC and persistently infected with a pestivirus PI were compared. The PI calves were infected with a HoBi Challenges in identifying and determining the impacts of infection with pestiviruses on the herd health of free ranging cervid populations. Although most commonly associated with the infection of domestic livestock, the replication of pestiviruses , in particular bovine viral diarrhea virus BVDV , occurs in a wide range of free ranging cervids including white-tailed deer, mule deer, fallow deer, elk, red deer, roe deer, eland and moused Circulating immune cell subpopulations in pestivirus persistently infected calves and non-infected calves varying in immune status [Abstract. The circulating immune cell subpopulations in cattle representing varying stages of immune status categorized as; colostrum deprived CD , receiving colostrum COL , colostrum plus vaccination VAC and persistently infected with a pestivirus PI were compared. The PI calves were infected with a H Four species of ruminant pestivirus are currently circulating in the United States U. A third bovin Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses. The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys in E2 as the site of disulfide bond linkage with E1 to form E1—E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain. Autocatalytic activity and substrate specificity of the pestivirus N-terminal protease Npro. Pestivirus N pro is the first protein translated in the viral polypeptide, and cleaves itself off co-translationally generating the N-terminus of the core protein. Once released, N pro blocks the host's interferon response by inducing degradation of interferon regulatory factor N pro' s intracellular autocatalytic activity and lack of trans-activity have hampered in vitro cleavage studies to establish its substrate specificity and the roles of individual residues. We constructed N pro -GFP fusion proteins that carry the authentic cleavage site and determined the autoproteolytic activities of N pro proteins containing substitutions at the predicted catalytic sites Glu22 and Cys69, at Arg that forms a salt bridge with Glu22, and at the cleavage site Cys Contrary to previous reports, we show that N pro' s catalytic activity does not involve Glu22, which may instead be involved in protein stability. Furthermore, N pro does not have specificity for Cys at the cleavage site even though this residue is conserved throughout the pestivirus genus. Transmission of a pestivirus infection in a population of Pyrenean chamois. Outbreaks of a previously unrecorded disease have recently affected Pyrenean chamois Rupicapra pyrenaica pyrenaica populations across the mountain range. A pestivirus was hypothesized to be the cause of this emerging disease and this type of virus can cross the species barrier and be transmitted to or from wildlife. Using an epidemiological survey conducted from to at Orlu, France, we characterized the virus and analyzed its transmission. A phylogenetic analysis of viral sequences and virus neutralization tests showed that the virus belonged to the newly described border disease virus-4 group. The increase of seroprevalence with age indicated that infection can occur at any age and resulted in lifelong immunity. Overall, Infection has thus been widespread in this population since , whereas no mass mortality or clinical signs have been observed. Incidence and seroprevalence varied seasonally and according to number of individuals aged less than 2 years old in the population, so viral transmission was dependent on host population age structure. We propose that the virus is now endemic in this population and is likely detrimental for reproduction and juveniles. Further investigation is needed to estimate the impact of pestivirus on host population dynamics and the risk of cross-transmission to farm animals. A survey of antibodies to pestivirus in sheep in the Republic of Ireland. Full Text Available Sera from 1, adult ewes in 91 flocks, representing all 26 counties in the Republic of Ireland, were examined for pestivirus antibodies using a commercially available ELISA which detected IgG1 antibody to border disease virus. Eighty-one sheep 5. Within infected flocks, the mean seroprevalence level was The highest antibody prevalence was detected in sheep from central lowland counties of Ireland. Although there are high numbers of infected flocks, many sheep within such flocks remain antibody-negative and are at risk of giving birth to lambs with congenital border disease. Congenital infection with atypical porcine pestivirus APPV is associated with disease and viral persistence. In , several Austrian piglet-producing farms recorded outbreaks of action-related repetitive myoclonia in newborn piglets "shaking piglets". Malnutrition was seen in numerous piglets as a complication of this tremor syndrome. Histological examination of the CNS of affected piglets revealed moderate hypomyelination of the white substance in cerebellum and spinal cord. In confirmation with previous reports, APPV genomes were identified in different body fluids and tissues including the CNS of diseased piglets. APPV could be isolated from a "shaking piglet", which was incapable of consuming colostrum, and passaged on different porcine cells at very low titers. APPV genomes were detected continuously in piglets that gradually recovered from CT, while the antibody titers decreased over a week interval, pointing towards maternally transmitted antibodies. High viral loads were detectable by qRT-PCR in saliva and semen of infected young adults indicating a persistent infection. Serum neutralization as a differential serological test for classical swine fever virus and other pestivirus infections. Ninety-nine sera out of a sample of 16, were positive for antibodies to pestiviruses in an ELISA test which did not distinguish antibodies to different pestiviruses. In most of these sera 13 out of 17 the differences between SN titres against the three viruses were not sufficient to estimate which was the most likely antibody-inducing virus. It was concluded that, for the SN to be useful in such differentiation, it is essential to examine a sample which must include a representative number of sera from the same farm where suspect animals were detected. When isolated serum samples are examined, such as those obtained with the sampling strategy adopted here, the SN may give rise to inconclusive results. Gaeta N. Departamento de Clínica Médica. E-mail: natalia. There were no associations between any reagent animals and the risk factors studied. This work is one of the pioneers in the study of the prevalence of anti- pestivirus antibodies in Brazilian sheep flocks. The low frequency and low viral titer observed suggest that pestivirus are not an important agent related to the presence of reproductive disorders in sheep herds. Comparison of the cross-antibody response induced in sheep by inactivated bovine viral diarrhoea virus 1 and Hobi-like pestivirus. Hobi-like pestivirus , a new tentative species within genus Pestivirus , was firstly detected in foetal bovine serum batches and later associated to respiratory distress and reproductive failures in cattle. In the present study, the cross-antibody response between bovine viral diarrhoea virus 1 BVDV-1 and the emerging pestivirus was evaluated in the sheep model. Ten sheep were immunised against BVDV-1 or Hobi-like pestivirus using inactivated preparations and the induced antibody responses were evaluated against the homologous and heterologous viruses. The results showed that heterologous antibody titres were significantly lower than the homologous ones, thus suggesting the need to develop specific vaccines against the emerging pestiviral species. Circulation of multiple subtypes of bovine viral diarrhoea virus type 1 with no evidence for HoBi-like pestivirus in cattle herds of southern Italy. In the present paper, the results of an epidemiological survey for pestiviruses circulating in cattle in southern Italy are presented. BVDV-1 displayed a high level of genetic heterogeneity, which can have both prophylactic and diagnostic implications. In addition, the detection of BVDV-2c highlights the need for a continuous surveillance for the emergence of new pestivirus strains in cattle farms in southern Italy. HoBi-like pestiviruses are emerging pestiviruses that infect cattle causing clinical forms overlapping to those induced by bovine viral diarrhea virus BVDV 1 and 2. As a consequence of their widespread distribution reported in recent years, molecular tools for rapid discrimination among pestiviruses infecting cattle are needed. The aim of the present study was to develop a multiplex real-time RT-PCR assay, based on the TaqMan technology, for the rapid and unambiguous characterisation of all bovine pestiviruses , including the emerging HoBi-like strains. The assay was found to be sensitive, specific and repeatable, ensuring detection of as few as 10 0 1 viral RNA copies. No cross-reactions between different pestiviral species were observed even in samples artificially contaminated with more than one pestivirus. From this classic traditional source may be derived the concept of a balanced and complete diet and probably the world's first dietary guidelines. Basic to the tradition are han, re, wen and bu foods, respectively 'cold', 'hot', 'neutral', 'strengthening'. Basic to Chinese cuisine are jan and tsai- 'cereal' the rice staple and main meal and 'dishes' to accompany the rice. Chinese traditional medicine, as in Huang Di Nei Jing, considers the nourishment of body and mind. It also emphasises that herbal medicine and food have the same origin. Diet was essential to the prevention of disease which a glossary of Chinese terms is given at the end of the paper in the Chinese tradition, was superior to treatment. Treatment of TB requires long-term courses of multi-drug therapies to eliminate subpopulations of bacteria, which sometimes persist against antibiotics. Therefore, understanding of the mechanism of Mtb antibiotic-resistance is extremely important. During infection, Mtb overcomes a variety of body defense mechanisms, including treatment with the reactive species of oxygen and nitrogen. The bases in DNA molecule are susceptible to the damages caused by reactive forms of intermediate compounds of oxygen and nitrogen. Most of this damage is repaired by the base excision repair BER pathway. Methods: XthA, nfo, and nei genes were identified in mycobacteria by homology search of genomic sequences available in the GenBank database. The protein products of Mtb genes were expressed and purified in Escherichia coli using affinity tags. The enzymatic activity of purified Nfo, XthA, and Nei 2 proteins were measured using radioactively labeled DNA substrates containing various modified residues. The plasmid constructs were verified by sequencing and then transformed into the Escherichia coli BL21 DE3 strain. Identification of the isolated proteins was performed by. The aim of this study was to evaluate different approaches to scoring the National Eye Institute Visual Functioning Questionnaire NEI VFQ in patients with low vision including scoring by the standard method, by Rasch analysis, and by use of an algorithm created by Massof to approximate Rasch person measure. Subscale validity and use of a 7-item short form instrument proposed by Ryan et al. NEI VFQ data from 50 patients with low vision were analyzed using the standard method of summing Likert-type scores and calculating an overall average, Rasch analysis using Winsteps software, and the Massof algorithm in Excel. Correlations between scores were calculated. Rasch person separation reliability and other indicators were calculated to determine the validity of the subscales and of the 7-item instrument. Scores calculated using all three methods were highly correlated, but evidence of floor and ceiling effects was found with the standard scoring method. None of the subscales investigated proved valid. The 7-item instrument showed acceptable person separation reliability and good targeting and item performance. Although standard scores and Rasch scores are highly correlated, Rasch analysis has the advantages of eliminating floor and ceiling effects and producing interval-scaled data. The Massof algorithm for approximation of the Rasch person measure performed well in this group of low-vision patients. The validity of the subscales VFQ should be reconsidered. Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle. We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine-amide NEI concentrations in discrete brain areas in male rats. To investigate the possible effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone LH , estradiol and progesterone concentrations were measured in control, hypothyroid hypoT, treated with PTU during days and hyperthyroid hyperT, l-T4 during days animals. Both treatments blunted the LH surge. Hypo- and hyperthyroidism increased estradiol concentrations during proestrus afternoon P-PM , although hypoT rats showed lower values compared to control during proestrus morning P-AM. NEI concentrations were lower in hypoT rats during the estrous cycle except in estrus E in the peduncular part of the lateral hypothalamus PLH. The present results indicate that NEI concentration is regulated in a complex manner by hypo- and hyperthyroidism in the different areas studied, suggesting a correlation between NEI values and the variations of gonadal steroid levels during estrous cycle. These changes could be, in part, responsible for the alterations observed in the hypothalamic-pituitary-gonadal axis in these pathologies. Prostatic biopsy in the prostate specific antigen gray zone; La biopsia prostatica multipla nalla zona grigia dei valori dell'antigene prostatico specifico. Drudi, F. La Sapienza, Rome Italy. Of the patients who gave full informed consent, 34 people were selected whose age range was between 56 to 76 years mean: PSA velocity was calculated collecting 3 blood samples every 30 days for 2 months. Our findings confirm that prostatic biopsy can detect tumors also in areas which appear normal at transrectal US and digital examination, and that PSA rate increases in patients with positive histology. Finally, the actual clinical role of prostatic biopsy relative to all other diagnostic imaging techniques remains to be defined. Di questi sono stati selezionati eta' tra 56 e 76 anni, eta' media 64 anni. Energy and telecommunications public services; Servizi pubblici nei settori dell'energia e delle telecomunicazioni. Salini, M. The aim of this work is the evolution of the energy and telecommunication public services. The article runs through the main stages in the public services' history and shows how open market rules may cause the future dissolution of public service notion. The conclusion wishes the hastening of public services privatisation and a Corporate Governance reform as a mean to pursue general interest. Se ne ripercorrono le principali tappe storiche e si evidenzia come le regole di apertura dei mercati possano causare la dissoluzione del concetto di servizio pubblico. Le conclusioni sottolineano la necessita' di accelerare la privatizzazione dei servizi pubblici e la riforma della Corporate Governance come strumento per il raggiungimento dell'interesse generale. The role of 3D Helical CT in the reconstructive treatment of maxillofacial cancers; Tomografia Computerizzata spirale con elaborazioni tridimensionali di superficie nel trattamento ricostruttivo dei tumori maligni del massiccio facciale. De Rosa, V. Nazionale Tumori Fondazione G. Pascale, Naples Italy ; Parascandolo, S. Further Ti features are strength, biocompatibility and easy handling. The prospect is provided to identify virtual 3D presurgical ablation planes. These may allow the surgeon to improve plastic reconstruction and shorten intervention time. Sono state eseguite dal al 11 ricostruzioni plastiche dell'osso mascellare per neoplasie osteodestruenti il massiccio facciale utilizzando materiale alloplastico. Applicato nel cavo residuo dell'osso un otturatore siliconato sormontante una protesi acrilica con arcata dentaria per la ricostruzione del palato. In due casi utilizzato pericardio bovino modulato sulla soluzione di continuo. Tutti i pazienti sono stati studiati con TC spirale sia nella fase preoperatoria che entro il sesto mese dall'intervento chirurgico. L'elaborazione tridimensionale della superificie sui dati ottenuti con acquisizione volumetrica ha fornito in tutti casi la fedele. Usual interstitial pneumonitis UIP presenting with Wells grade 3. Can imaging methods help predict further progression of disease? Fasano, L. Servizio di Medicina Nucleare; Battista, G. Three different grades of idiopathic pulmonary fibrosis can be identified by HRCT pattern. Patients with predominant ground-glass opacity grade 1 usually improve after treatment and may have a better prognosis. The subjects with a predominant reticular pattern and honeycombing grade 3. Nevertheless, these patients may worsen even in the absence of HRCT features of the so-called alveolitis. The aim of this report is to investigate the predictive role of some noninvasive imaging methods HRCT with visual score of disease extent; Gallium scintigraphy; DTPA scintigraphy in patients with idiopathic fibrosis and a prevalent macroscopic fibrosis at HRCT study. La fibrosi irreversibile tuttavia non e' necessariamente una situazione stabile ma puo progredire ed evolvere ulteriormente. In particolare i pazienti che gia all'esordio presentano solo i segni della fibrosi possono peggiorare a distanza di tempo nonostante la terapia. Scopo del lavoro e' stato quello di individuare in un gruppo di pazienti con prevalente fibrosi macroscopica quale possa essere un parametro preditivo della successiva evoluzione della malattia. Abdominal adipose tissue distribution in obese children. US versus CT measurements; Valutazione della distribuzione del tessuto adiposo addominale nei bambini obesi. Confronto tra ecografia e Tomografia Computerizzata. Ferrozzi, F. Clinica Pediatrica; Campani, R. Con l'ecografia sono state valutate le distanze tra il muscolo retto e la colonna vertebrale e tra il muscolo retto e l'aorta, senza e con compressione dosata, quali parametri indicativi dello spessore del grasso viscerale nonche' la distanza tra cute e muscolo retto quale indicatore del grasso sottocutaneo. I risultati dell'ecografia e della TC sono stati inoltre correlati con altre variabili morfometriche peso, peso corporeo ideale, plicometria cutanea. Non e' stata riscontrata alcuna correlazione tra l'indice di massa corporea e i dati ecografici e TC. I risultati ottenuti suggeriscono che l'ecografia puo' essere utilizzata in alternativa alla TC nella valutazione della distribuzione del grasso corporeo nei bambini obesi. Full Text Available Abstract Background The use of self-report questionnaires to substitute for visual acuity measurement has been limited. We examined the association between visual impairment and self reported visual function in a population sample of older people in the UK. Methods Cross sectional study of people aged more than 75 years who initially participated in a trial of health screening. After adjustment for age, gender, practice and NEI -VFQ sub-scale scores, those complaining of poor vision in general were 4. Self-reported limitations with social functioning and dependency on others due to poor vision were also associated with visual impairment odds ratios, 2. Those reporting difficulties with near vision and colour vision were more likely to be visually impaired odds ratios, 2. Although differences in NEI -VFQ scores were small, scores were strongly associated with visual acuity, binocular status, and difference in acuity between eyes. Conclusion NEI -VFQ questions regarding the quality of general vision, social functioning, visual dependency, near vision and colour vision are strongly and independently associated with an objective measure of visual impairment in an. Conversazioni autobiografiche con Albino Sacco-Casamassima. Olivetti venne a Matera con un certo ambasciatore americano che praticamente aveva preparato o stava dando una mano per il piano Marschall, venne a Matera e mi vollero incontrare. Io sono stato chiamato dalla piazza, stavo nella piazza, era il mese di luglio, una cosa di questo genere, e andai in un bar, un bar ad angolo mi ricordo in Via Don Minzioni, dove questo Olivetti mi disse 'ma lei che cosa fa coi sassi? Vision-related quality of life assessment using the NEI -VFQ in adolescents and young adults with a history of congenital cataract. Tra classicità ed emozione romantica", Tra classicità ed emozione romantica", Scicli, Edizioni di storia e studi sociali, [Book Review. Suburban amoebiasis. CT and US findings and percutaneous treatment of amoebic liver abscess; Amebiasi sub-urbana: aspetti diagnostici con tomografia computerizzata ed ecografia e trattamento percutaneo degli ascessi amebici del fegato. Servizio di Radiologia; Rossi, E. Servizio di Radiologia; Capuano, N. The study reports ultrasonography and computerise tomography findings in 16 patients with amoebic abscesses, 12 of whom lived in a temperate peripheral area north-east of Naples Italy. All patients have a clinical-diagnostic condition called sub-urban amoebiasis. The personal experience with the US guided therapeutic drainage of amoebic abscess with repeated cavity washing, which is important for positive parasitology. Combined US and CT assessment facilitated the diagnosis of amoebiasis and its differentiation from pyogenic abscess and hepatoma. Diversi studi confermano che la terapia medica dell'amebiasi risulta piu' efficace quando viene associato il drenaggio percutaneo degli ascessi epatici con piu' rapida guarigione clinica e risposta favorevole dell'organismo. Scopo del presente lavoro e' di descrivere gli aspetti ecografici e di tomografia computerizzata degli ascessi amebici in un gruppo di 16 pazienti , 12 dei quali residenti in zona temperata e periferica di una vasta area a nord-est di Napoli presentandosi con caratteristico e raro quadro clinico-diagnostico definito amebiasi sub-urbana. Si discute infine l'esperienza personale del drenaggio terapeutico sotto guida ecografica dell'ascesso con tecnica del lavaggio ripetuto dalla cavita', importante ai fini della positivita' dell'esame. L'associazione dei reperti tipici ecografici e TC ha consentito la diagnosi agevole dell'amebiasi differenziandola dall'ascesso piogenico e dall'epatoma. Scrittura e militanza: due stagioni di donne cattoliche nei Paesi Bassi Spagnoli secc. Donne attive in quanto militanti cattoliche. These women were catholic militants. The analysis is based on printed and unprinted female texts, according to their context of production the Erasmian humanism and the catholic and Spanish reconquest. Pratiche di Social Networking: una prima sperimentazione nei corsi di italiano L2 per studenti Erasmus. Yang, Joon Eon; Kang, D. Recently, under the de-regulation environment, nuclear industry has attempted various approaches to improve the economics of Nuclear Power Plants NPP. This approach uses the risk and performance information to manage the resources effectively and efficiently that are used in the operation of NPP. The nuclear industry and regulatory body of U. A have developed a measure to evaluate the quality of PSA. However, in Korea, there have been no attempts to evaluate the quality of PSA model itself. Therefore, we cannot be sure about the quality of PSA whether or not the present PSA model can be used for the risk-informed applications such as mentioned above. We, also, have derived what items are to be improved to upgrade the quality of PSA model and how it can be improved. Il processo Andreotti. Il confine labile fra la partecipazione e il concorso esterno nei reati associativi. As a result of this analysis we come to ascertain how fleeting the boundary between the role of partecipant and external competitor in a criminal conspiracy can be, especially in case of. Informed consent is an essential element in doctor-patient relationship. In particular, obtaining valid informed consent from patients with neurocognitive diseases is a critical issue at present. For this reason, we decided to conduct research on elderly patients with Alzheimer's disease Diagnostic and Statistical Manual of Mental Disorders, 5th Edition DSM-5 to assess their capacity to make treatment decisions. The experimental group comprised 70 Alzheimer patients who were admitted to the Neurodegenerative Disease Unit of the University of Bari. The control group consisted of 83 elderly patients without neurocognitive disorders who were hospitalized in the Geriatric Unit at the same university. After providing written consent to participate in the research, each subject underwent the following assessments: a assessment of comprehension sheet, b Neuropsychiatric Inventory NPI and Global Functioning Evaluation GFE , c neurological evaluation, d neuropsychological assessment with a full battery of tests, d The MacArthur Treatment Competence Study MacArthur Competence Assessment Tool for Treatment MacCAT-T ; understanding, appreciating, reasoning and expressing a choice and e a semi-structured interview administered by the patient's caregiver. The present survey was designed to analyze possible qualitative and quantitative correlations between cognitive functioning and capacity to consent in relation to different degrees of severity of the neurodegenerative disorder. A large portion of the patients in our experimental sample did not appear to have the capacity to provide a valid consent. The authors present initial results of this study and discuss their possible implications. Chest pain and acute dyspnoea are frequent causes of emergency medical services activation. The pre-hospital management of these conditions is heterogeneous across different regions of the world and Europe, as a consequence of the variety of emergency medical services and absence of specific prac Valutazione morfo-funzionale in pazienti ipertesi con stenosi dell'arteria renale; Correlazioni tra angiografia e scintigrafia dinamica. Morpho-functional evaluation in hypertensive patients with renal artery stenosis; Correlations between angiography and radionuclide renography. Cattedra di Medicina Nucleare. By comparison with current version of Huang di nei jing, most of the descriptions are similar, yet still with some differences, such as yin-yang nature of the five zang visceras, the liver being the root of "pi ji", the spleen being the root of "cang lin" etc. Wu xing da yi epitomizes the books about yin-yang and five phases before the Sui Dynasty, while Xiao Ji's quotations from Huang di nei jing interpreted from the views of yin-yang and five phases, are different from the annotations of later ages. Hereditary haemorrhagic telangiectasia: study of hepatic vascular alterations with multi-detector row helical CT and reconstruction programs; Telangiectasia emorragica ereditaria: TC multidetettore multifasica e programmi di ricostruzione nello studio delle alterazioni vascolari epatiche. Centro Interdipartimentale per lo studio dell' HHT. Materials and methods: An MDCT multiphasic study of the liver was performed in consecutive patients: 89 considered to be affected by HHT and 16 with suspicion of disease alone. The scan delay was determined by using a test bolus of contrast material. The CT examination was performed with a triphasic technique double arterial phase and portal venous phase. Therefore HHT diagnosis was excluded in 5 patients. Conclusions: Multiphasic MDCT and the new reconstruction programs enable the identification and characterisation of the complex vascular alterations typical of HHT. Materiale e metodi: E' stato eseguito uno. Valutazione e mappatura dei servizi culturali nei paesaggi terrazzati. Il caso studio della Costiera Amalfitana. Full Text Available I paesaggi culturali rappresentano una risorsa fondamentale per lo sviluppo sostenibile. Attualmente molti paesaggi terrazzati sono considerati a rischio a causa delle mutate condizioni socio-economiche. Viene affrontato il tema della valutazione e mappatura dei servizi culturali, con riferimento al paesaggio terrazzato della Costiera Amalfitana in Campania. Vodafone cuenta actualmente con cerca de 14 millones de clientes de telefonía móvil y unos Compartir en Twitter. Desde el año , Bélgica ya obligaba al empleador a compensar a los empleados que trabajaban a distancia con 20 euros mensuales por el uso de su propio ordenador, y 20 euros adicionales por la utilización profesional de una conexión a internet personal. Ayudas que ahora, y en determinados casos podrían llegar a sumarse a los ,48 euros mensuales fijados. Así, si lo hacen un día a la semana el pago es de 10 euros mensuales, si lo hacen dos días a la semana es de 20 euros mensuales En Suiza no hay una legislación que establezca una compensación para los trabajadores que realicen su función desde casa. Pero una reciente sentencia de un Tribunal Federal, recogida por RTS, ha obligado a una empresa a pagar a un trabajador al que obligó a teletrabajar , fijando una indemnización de francos suizos unos euros al mes. Por su parte, Alemania lleva trabajando en el desarrollo de su normativa sobre el teletrabajo desde abril, como anunció su ministro de Trabajo, Hubertus Heil, que quiere que los trabajadores puedan seguir trabajando a distancia tras la pandemia..

The results were compared with the histological findings Vittorio colao esposa disfunción sexual biopsy or surgery. Histology diagnosed three fibroadenomas, 5 ductal carcinoma in situ, 2 lobular carcinomas in situ, 3 invasive ductal carcinomas and 1 invasive lobular carcinoma. Contrast enhanced MRM yielded no false negative Vittorio colao esposa disfunción sexual three false positives. Our results demonstrate a very good accuracy of Magnetic Resonance Mammography in the detection of synchronous contralateral cancer in patients with newly diagnosed breast cancer.

Therefore, contrast-enhanced MRM could be introduced to screen patients with proven breast cancer before they under-go surgery. Definire il ruolo della Risonanza Magnetica nella valutazione della read article contro laterale in pazienti con tumore della mammella recentemente diagnosticato.

Cinquanta pazienti con tumore monolaterale della mammella e mammella controlaterale. Polimorfismi nei geni metabolici come fattori dirischio per il carcinoma gastrico GC: risultati preliminari di uno studio caso-controllo.

Risultati : le frequenze dei polimorfismi nei geni metabolici sono risultate in alcuni casi differenti nei casi rispetto ai controlli sebbene go here si evidenzi una differenza statisticamente significativa.

In particolare il genotipo GSMT1 null è più elevato nei pazienti rispetto ai controlli Vittorio colao esposa disfunción sexual : i risultati preliminari di questo studio evidenziano associazioni tra alcuni genotipi metabolici e parametri clinico-patologici, che se confermati potrebbero permettere di identificare sottogruppi con prognosi più sfavorevole di GC da indirizzare preventivamente verso trattamenti specifici.

Valutazione del carico di stress nei Vigili del Fuoco: correlazione con il profilo psicologico ed alcuni indicatori biologici di rischio. Un sottogruppo di vigili ha fornito anche un campione di saliva dopo un turno lavorativo notturno condizione di stress.

Conclusioni : i Vigili del Fuoco sono risultati meno ansiosi, più predisposti al rischio e con un profilo di personalità di tipo realistico in linea con la scelta professionale. CF findings of bowel infarction in 56 surgical patients, 5 of whom with reversible ischemia; Aspetti alla tomografia computerizzata dell'infarto intestinale. Salzano, A. Cardarelli, Naples Italy. Servizio di Neuroradiologia. Diagnosis on often late because clinical signs, laboratory data and radiologic Vittorio colao esposa disfunción sexual are a specific.

The authors investigated radiographic and particular CT Vittorio colao esposa disfunción sexual of intestinal infraction in 56 patients submitted to surgery within 12 hours of admission. We also report the CT findings of 5 of these patients who had reversible mesenteric ischemia. Short Time And 3gp.

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